4.7 Review

Aggregation-induced emission biomaterials for anti-pathogen medical applications: detecting, imaging and killing

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Revealing the In Situ Behavior of Aggregation-Induced Emission Nanoparticles and Their Biometabolic Effects via Mass Spectrometry Imaging

Junyu Chen et al.

Summary: Simultaneous imaging and analysis of exogenous nanomaterials and endogenous metabolites in tissue was achieved using label-free mass spectrometry imaging. This approach allowed for the identification of heterogeneous deposition and clearance behaviors of nanoparticles in organs, as well as the detection of distinct endogenous metabolic changes in normal tissues. It was found that the accumulation of nanoparticles in tumors did not benefit from abundant tumor vessels. Additionally, spatial-selective metabolic changes were observed during nanoparticle-mediated photodynamic therapy, shedding light on the mechanism of apoptosis induction in cancer therapy.

ACS NANO (2023)

Article Engineering, Biomedical

The commercial antibiotics with inherent AIE feature: In situ visualization of antibiotic metabolism and specifically differentiation of bacterial species and broad-spectrum therapy

Bingnan Wang et al.

Summary: Pharmacology research often focuses on the structure-activity relationships of drugs, neglecting their optical properties. This study discovered a class of commercial antibiotics with aggregation-induced emission characteristics, allowing for in situ visualization of antibiotic metabolism and the development of a derivative that can differentiate bacterial species.

BIOACTIVE MATERIALS (2023)

Article Chemistry, Multidisciplinary

Precise and long-term tracking of mitochondria in neurons using a bioconjugatable and photostable AIE luminogen

Hojeong Park et al.

Summary: This study developed a novel fluorescent dye that can accurately and long-term track the movement of mitochondria in neurons.

CHEMICAL SCIENCE (2022)

Review Pharmacology & Pharmacy

Antibacterial biomaterials for skin wound dressing

Yuqing Liang et al.

Summary: Bacterial infection and resistance pose a significant threat to human health, especially in wound healing. This review focuses on antibacterial wound dressings and discusses various biomaterials and antibacterial agents used in their fabrication. It also explores challenges and future perspectives in this field.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Review Chemistry, Multidisciplinary

Aggregation-Induced Fluorogens in Bio-Detection, Tumor Imaging, and Therapy: A Review

Yekkuni L. Balachandran et al.

Summary: This review summarizes the recent developments in the design strategy, bio-detection, cell imaging, tumor imaging, vascular imaging, and image-guided tumor therapy of aggregation-induced emission (AIE) fluorogens. The microfluidic approach to synthesize AIE nanoparticles (NPs) and current challenges and potentials of AIE NPs are highlighted.

CCS CHEMISTRY (2022)

Article Chemistry, Physical

In Situ Electrospinning of Aggregation-Induced Emission Nanofibrous Dressing for Wound Healing

Ruihua Dong et al.

Summary: A novel in situ deposited and personalized nanofibrous dressing is developed for rapid wound dressing and effective antibacterial therapy. The dressing can be directly electrospun on skin wounds and fits various sizes of wounds perfectly. Loaded with an aggregation-induced emission luminogen, the nanofibrous dressings exhibit long-term antibacterial activity and show excellent antimicrobial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. In vivo studies demonstrate that these antibacterial nanofibrous dressings effectively reduce inflammation and accelerate wound healing. This in situ produced antibacterial dressing shows promise as a total solution for treating emergencies.

SMALL METHODS (2022)

Article Engineering, Biomedical

Rapid and high-throughput testing of antifungal susceptibility using an AIEgen-based analytical system

Xiaoxue Ge et al.

Summary: Increasing resistance among fungi to antimicrobials poses global health threats. A new antifungal susceptibility testing (AFST) method using a luminogen with aggregation-induced emission characteristics (AIEgen) called DMASP can assess fungal susceptibility to various antimicrobials within 12 hours, rapidly detect possible drug-resistant fungal strains, and guide the precise use of antimicrobials.

BIOMATERIALS (2022)

Article Engineering, Biomedical

Huang a,1, 1, Deliang Wang b, a, d, a, Qiao Jin a, b,**, Ben

Yue Huang et al.

Summary: The development of antibiotics resistance has become a global health issue. Photothermal therapy offers a potential solution for treating multidrug-resistant bacterial infections. In this study, a polymeric luminogen with aggregation-induced emission was synthesized and used as a photothermal agent. The effectiveness of the agent was demonstrated in animal models of infected wounds.

BIOMATERIALS (2022)

Article Engineering, Biomedical

Recent advances of aggregation-induced emission materials for fluorescence image-guided surgery

Wei He et al.

Summary: This article investigates the application of aggregation-induced emission materials in intraoperative guidance, with a focus on deep tissue penetration ability, high brightness, and targeted strategies for tumor or other pathology. The article outlines representative interdisciplinary achievements and briefly discusses the challenges and future opportunities of AIE materials.

BIOMATERIALS (2022)

Article Engineering, Biomedical

Inspiration from nature: BioAIEgens for biomedical and sensing applications

Michelle M. S. Lee et al.

Summary: This review highlights the latest development of bioproduct-inspired luminescent materials (BioAIEgens) with aggregation-induced emission (AIE) characteristics discovered from natural herbs. These BioAIEgens exhibit high biocompatibility, low costs, and easy preparation, making them promising candidates for biomedical and sensing applications.

BIOMATERIALS (2022)

Article Engineering, Biomedical

Ultrabright nanoparticle-labeled lateral flow immunoassay for detection of anti-SARS-CoV-2 neutralizing antibodies in human serum

Lun Bian et al.

Summary: The researchers developed an ultrabright nanoparticles-based lateral flow immunoassay for rapid semi-quantitative detection of anti-SARS-CoV-2 neutralizing antibodies in serum samples. The method accurately identified negative and positive samples with high precision. The study highlights the practical value of the established assay in assessing acquired protective immunity against SARS-CoV-2.

BIOMATERIALS (2022)

Review Engineering, Biomedical

Photothermal agents based on small organic fluorophores with intramolecular motion

Fangyuan Lv et al.

Summary: This review summarizes the recent progress of photothermal agents (PTAs) based on small organic fluorophores with intramolecular motion. The design strategies and potential applications of these dyes are highlighted.

ACTA BIOMATERIALIA (2022)

Article Biophysics

A clickable AIEgen for visualization of macrophage-microbe interaction

Zicong Zhang et al.

Summary: The visualization of immunocyte-microbe interaction is crucial for understanding the immune system. This paper presents a clickable AIE probe that allows for the high-resolution imaging of macrophage-bacterium interactions.

BIOSENSORS & BIOELECTRONICS (2022)

Editorial Material Infectious Diseases

The Johns Hopkins University Center for Systems Science and Engineering COVID-19 Dashboard: data collection process, challenges faced, and lessons learned

Ensheng Dong et al.

Summary: Johns Hopkins University launched the first global real-time coronavirus surveillance system, which has served the global audience for over 30 consecutive months and accumulated a significant amount of data requests and page views. This article reveals the technical details and challenges of the system, providing insights for future large-scale public health-related data collection and reporting.

LANCET INFECTIOUS DISEASES (2022)

Article Materials Science, Biomaterials

Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan-indocyanine green/luteolin nanocomposites for wound healing

Pei-Yao Xu et al.

Summary: In this study, a near-infrared/acid-induced nanoplatform was developed for antibacterial and antibiofilm effects in skin wound healing. The nanoplatform exhibited high encapsulation efficiency and improved drug release behavior, resulting in exceptional bacteria-killing and biofilm elimination effects. The combination of chemotherapy and photothermal therapy outcomes further promoted wound healing.

REGENERATIVE BIOMATERIALS (2022)

Article Nanoscience & Nanotechnology

AIE-Active Antibiotic Photosensitizer with Enhanced Fluorescence in Bacteria Infected Cells and Better Therapy Effect toward Drug-Resistant Bacteria

Bingnan Wang et al.

Summary: This study covalently attached an AIE photosensitizer to the antibiotic of moxifloxacin hydrochloride (MXF-HCl) and synthesized an antibiotic derivative, MXF-R, with pharmacological activity and photodynamic activation. MXF-R showed enhanced fluorescence after specifically binding to bacteria in infected cells, enabling in situ visualization of the bacteria. MXF-R exhibited better antibacterial activity than its parent antibiotic in chemo- and photodynamic therapy, and it effectively killed moxifloxacin resistant bacteria.

ACS APPLIED BIO MATERIALS (2022)

Article Chemistry, Multidisciplinary

Leveraging bacterial survival mechanism for targeting and photodynamic inactivation of bacterial biofilms with red natural AIEgen

Michelle M. S. Lee et al.

Summary: This study reports a naturally occurring red aggregation-induced emission luminogen (AIEgen), Tanshinone IIA, which can specifically target bacterial biofilms and effectively eliminate bacteria through photodynamic therapy.

CELL REPORTS PHYSICAL SCIENCE (2022)

Article Chemistry, Multidisciplinary

A receptor-targeting AIE photosensitizer for selective bacterial killing and real-time monitoring of photodynamic therapy outcome

Cheng Wang et al.

Summary: A receptor-targeting AIE photosensitizer (CE-TPA) has been synthesized for selective killing of Gram-positive bacteria. It shows efficient bactericidal activity against methicillin-resistant Staphylococcus aureus, and its polarity-sensitive property allows for real-time monitoring of photodynamic bactericidal outcome.

CHEMICAL COMMUNICATIONS (2022)

Review Chemistry, Multidisciplinary

Organic photosensitizers for antimicrobial phototherapy

Van-Nghia Nguyen et al.

Summary: Microbial infectious diseases, especially those caused by new and antibiotic-resistant bacteria, pose a significant threat to global human health. Phototherapy, as an antibiotic-free treatment, shows promise in treating microbial infections due to its selectivity, non-invasiveness, minimal side effects, and broad antimicrobial activity. This tutorial review provides an overview of the concept and significance of phototherapy, as well as recent research progress in using organic photosensitizers for antimicrobial applications.

CHEMICAL SOCIETY REVIEWS (2022)

Article Chemistry, Multidisciplinary

A wearable AIEgen-based lateral flow test strip for rapid detection of SARS-CoV-2 RBD protein and N protein

Guo-Qiang Zhang et al.

Summary: This study developed test strips for the detection of SARS-CoV-2 using AIE luminogens as reporters, achieving high sensitivity and specificity with limits of detection as low as 6.9 ng/mL for RBD protein and 7.2 ng/mL for N protein. The integration of the test strips onto N95 masks simplified the sampling procedures and showed high anti-interference capacity in complex biosamples.

CELL REPORTS PHYSICAL SCIENCE (2022)

Review Chemistry, Multidisciplinary

Fluorogenic Probes/Inhibitors of β-Lactamase and their Applications in Drug-Resistant Bacteria

Yang Ding et al.

Summary: Beta-lactam antibiotics are important inventions in treating infections, but the emergence of beta-lactamase in bacteria leads to drug resistance. Various detection methods and inhibitors are available, and designing improved probes may help overcome bacterial resistance.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Infectious Diseases

Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection

Bo Diao et al.

Summary: The FIC assay for NP antigen testing shows high specificity and relatively high sensitivity in early-phase SARS-CoV-2 diagnosis, according to a study conducted in Wuhan and Chongqing between February 10 and 15, 2020.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Review Engineering, Biomedical

AIEgens for microbial detection and antimicrobial therapy

Haotian Bai et al.

Summary: The emergence of antibiotic-resistant microbes poses a serious threat to human health, highlighting the urgent need for research and development of new antimicrobial systems and strategies. AIEgen-based biofunctional materials and systems offer rapid microbial detection, bacterial classification, and pathogen discrimination, aiding in the scientific study of antibiotic resistance mechanisms.

BIOMATERIALS (2021)

Article Chemistry, Multidisciplinary

Organic Photo-antimicrobials: Principles, Molecule Design, and Applications

Bei Ran et al.

Summary: The use of photo-antimicrobials (PAMs) in phototherapy (PT) offers a new approach to combat multi-drug-resistant pathogens. By reacting with cell membranes, PAMs can effectively eradicate various pathogens, making them suitable for treating local infections, wound dressings, and biofilm removal from medical devices. Further development of organic photo-antimicrobials (OPAMs) is crucial for addressing the general challenges in microbial infections, especially during the global COVID-19 epidemic.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Review Biotechnology & Applied Microbiology

A global view on fungal infections in humans and animals: opportunistic infections and microsporidioses

S. Gnat et al.

Summary: This paper discusses the global status of infectious diseases, focusing on the increasing trend of opportunistic fungal infections and the characteristics of various pathogens. It also introduces the etiology, epidemiology, and symptoms of fungal infections.

JOURNAL OF APPLIED MICROBIOLOGY (2021)

Review Oncology

Progress and trends of photodynamic therapy: From traditional photosensitizers to AIE-based photosensitizers

Shuai Wang et al.

Summary: Photodynamic therapy utilizes excitation light to activate photosensitizers and generate reactive oxygen species for cancer cell death. Traditional PSs have limitations, while aggregation-induced emission (AIE) based PSs show great potential in overcoming these issues. This review examines the design strategy and biomedical applications of AIE PSs, highlighting their effectiveness as theranostic agents.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

Review Chemistry, Multidisciplinary

Imaging Commensal Microbiota and Pathogenic Bacteria in the Gut

Liyuan Lin et al.

Summary: The gut microbiota, as a newly discovered organ, plays diverse and fundamental roles in host physiology. Current research heavily relies on DNA sequencing-based methodologies, but the visualization of these microbes in the intestines poses formidable difficulties. Efforts have been devoted to developing suitable imaging tools and strategies to understand the complex biological interactions between commensal microbiota and pathogenic bacteria.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

Article Chemistry, Multidisciplinary

Early Detection of SARS-CoV-2 Seroconversion in Humans with Aggregation-Induced Near-Infrared Emission Nanoparticle-Labeled Lateral Flow Immunoassay

Rui Chen et al.

Summary: A new serological diagnostic method was designed for early detection of COVID-19 using AIE nanoparticles. The method showed comparable or higher sensitivity to ELISA and outperformed a commercial colloidal gold nanoparticle test strip. Early detection of IgM and IgG was achieved within 1-7 days of symptom onset with the AIE nanoparticle-based test strip.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Biologically Excretable Aggregation-Induced Emission Dots for Visualizing Through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine

Zhe Feng et al.

Summary: The newly designed PEGylated AIE (OTPA-BBT) dots with strong absorption, extremely high NIR-II PLQY, and long aliphatic chain design can be excreted from animal bodies. These dots emit bright fluorescence beyond 1100 nm and are used for monitoring cerebral vasculature and gastrointestinal tract, demonstrating biosafety.

ADVANCED MATERIALS (2021)

Article Engineering, Biomedical

More is less: Creation of pathogenic microbe-related theranostic oriented AIEgens

Rong Hu et al.

Summary: Theranostic agents based on photo-dynamic therapy have the features of noninvasiveness, spatial-temporal control, and lack of drug resistance. A multifunctional nanoprobe designed based on the principle of "More is Less" can selectively illuminate fungi and target anti-microbes, with good aggregation-induced emission properties and selectivity towards fungi.

BIOMATERIALS (2021)

Article Chemistry, Multidisciplinary

Rapid One-Step Detection of Viral Particles Using an Aptamer-Based Thermophoretic Assay

Jinqi Deng et al.

Summary: The study introduces a one-step thermophoretic assay for rapid and sensitive detection of viral particles, specifically targeting the spike protein of SARS-CoV-2. The assay achieved a low limit of detection in a short time without the need for pretreatment, demonstrating high accuracy when detecting synthetic samples. This thermophoretic assay could potentially enhance diagnostic tools for viral pathogens due to its simplicity, speed, and cost-effectiveness.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Chemistry, Analytical

A dibenzothiophene core-based small-molecule AIE probe for wash-free and selective staining of lipid droplets in live mammalian and fungal cells

Sayed Mir Sayed et al.

Summary: This study introduces a novel fluorescent probe, TPA-DBTD, capable of selectively imaging LDs in live cells and tracking the dynamic changes of LDs, suitable for staining LDs in mammalian cells and fungi.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

Article Chemistry, Multidisciplinary

Antiviral and Anti-Inflammatory Treatment with Multifunctional Alveolar Macrophage-Like Nanoparticles in a Surrogate Mouse Model of COVID-19

Bin Li et al.

Summary: The development of multifunctional alveolar macrophage-like nanoparticles (NPs) with photothermal inactivation capability provides a potential treatment strategy for COVID-19, offering combined antiviral and anti-inflammatory effects. In a mouse model of COVID-19, treatment with NIR-irradiated NPs decreases virus burden and cytokine levels, reduces lung damage and inflammation, and improves survival rates. This therapeutic approach may be applicable for early-stage COVID-19 treatment through atomization inhalation of NPs followed by NIR irradiation of the respiratory tract, reducing infection progression and transmission risk.

ADVANCED SCIENCE (2021)

Article Chemistry, Multidisciplinary

Mitochondria-Specific Aggregation-Induced Emission Luminogens for Selective Photodynamic Killing of Fungi and Efficacious Treatment of Keratitis

Chengcheng Zhou et al.

Summary: By utilizing mitochondrial-targeting luminogens with aggregation-induced emission characteristics, selective and highly efficient killing of fungi can be achieved, showing significantly better therapeutic effects in clinical applications.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Fabrics Attached with Highly Efficient Aggregation-Induced Emission Photosensitizer: Toward Self-Antiviral Personal Protective Equipment

Bin Li et al.

Summary: This study introduces a fabric manufacturing method based on a highly efficient aggregation-induced emission photosensitizer (ASCP-TPA) for real-time self-antiviral capabilities. The fabrics show significant photodynamic inactivation effects against a surrogate coronavirus MHV-A59, with >99.999% virions eliminated within 10 minutes under ultralow-power white light irradiation. These self-antiviral fabrics offer reusability, long-term usability, and no toxicity to normal skin, making them a promising solution to global PPE supply shortages.

ACS NANO (2021)

Article Engineering, Biomedical

AIEgen-loaded nanofibrous membrane as photodynamic/photothermal antimicrobial surface for sunlight-triggered bioprotection

Meng Li et al.

Summary: This study developed a novel nanofibrous membrane that possesses both microbe interception and self-decontamination effects, capable of efficiently inactivating pathogenic aerosols under sunlight irradiation.

BIOMATERIALS (2021)

Article Chemistry, Multidisciplinary

A Membrane-Targeting Photosensitizer with Aggregation-Induced Emission Characteristics for Highly Efficient Photodynamic Combat of Human Coronaviruses

Ming-Yu Wu et al.

Summary: This study reports the efficient inactivation of human coronavirus with photodynamic therapy using photosensitizers with aggregation-induced emission characteristics. The photosensitizer can effectively target and inactivate the virus under light irradiation, providing a new avenue for combating COVID-19 with photodynamic therapy.

SMALL (2021)

Review Engineering, Biomedical

Aggregation-Induced Emission-Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

Xiaohui Chen et al.

Summary: The prevention and control of pathogenic bacteria, fungi, and viruses is a global challenge in public health. AIEgens are considered as potential treatment strategies for detecting and treating related infections.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Materials Science, Biomaterials

Evaluation of the anti-biofilm activities of bacterial cellulose-tannic acid-magnesium chloride composites using an in vitro multispecies biofilm model

Wei He et al.

Summary: Chronic wounds are a global issue often accompanied by infections. The BC-TA-Mg composites exhibited excellent anti-biofilm activities and water absorption capacity, making them suitable for chronic wound care. The composites also showed increased tensile strength without compromising transparency, and demonstrated good inhibitory effects on bacterial biofilms.

REGENERATIVE BIOMATERIALS (2021)

Article Chemistry, Multidisciplinary

Highly efficient photothermal nanoparticles for the rapid eradication of bacterial biofilms

Wei He et al.

Summary: Organic nanoparticles with highly efficient photothermal conversion were designed and prepared to eliminate mature bacterial biofilms upon low-power near-infrared laser irradiation. These nanoparticles show great promise for rapid eradication of bacterial biofilms through photothermal therapy.

NANOSCALE (2021)

Review Chemistry, Multidisciplinary

Recent advances of AIE light-up probes for photodynamic therapy

Shanshan Liu et al.

Summary: As a new non-invasive treatment method, photodynamic therapy (PDT) has attracted attention in biomedical applications due to the advantages of possessing fluorescence for photosensitizers. The unique features of aggregation-induced emission (AIE) fluorogens provide new opportunities for facile design of light-up probes with high signal-to-noise ratios and improved theranostic accuracy and efficacy for image-guided PDT. The review summarizes recent advances of AIE light-up probes for PDT, introducing strategies and principles for designing AIE photosensitizers and light-up probes and elaborating on their applications in photodynamic antitumor and antibacterial applications.

CHEMICAL SCIENCE (2021)

Article Chemistry, Multidisciplinary

Novel strategy to prepare fluorescent polymeric nanoparticles based on aggregation-induced emission via precipitation polymerization for fluorescent lateral flow assay

Guan Wang et al.

Summary: Fluorescent polymeric nanoparticles (FPPs) have attracted attention in fluorescent lateral flow assay (FLFA) for their biocompatibility, stability, and sensitivity. A novel strategy utilizing aggregation-induced emission luminogens (AIEgen) for preparing FPPs is proposed, with FPPs@210 showing optimal performance for FLFA testing using COVID-19 antibodies as targets. This study presents a promising approach for constructing FLFA strips with ideal FPPs for bioassays.

MATERIALS CHEMISTRY FRONTIERS (2021)

Review Chemistry, Multidisciplinary

Precise Molecular Design for High-Performance Luminogens with Aggregation-Induced Emission

Shidang Xu et al.

ADVANCED MATERIALS (2020)

Article Chemistry, Multidisciplinary

Visualization and In Situ Ablation of Intracellular Bacterial Pathogens through Metabolic Labeling

Fang Hu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Engineering, Biomedical

Antibacterial biohybrid nanofibers for wound dressings

Shahin Homaeigohar et al.

ACTA BIOMATERIALIA (2020)

Review Chemistry, Multidisciplinary

Aggregation-Induced Emission: New Vistas at the Aggregate Level

Zhao Zheng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Chemistry, Multidisciplinary

Aggregation-Induced Emission: Recent Advances in Materials and Biomedical Applications

Xiaolei Cai et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Medicinal

Aggregation-Induced Emission Photosensitizers: From Molecular Design to Photodynamic Therapy

Jun Dai et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Biotechnology & Applied Microbiology

Cell membrane-coated nanoparticles: research advances

Shuaijun Zou et al.

NANOMEDICINE (2020)

Article Multidisciplinary Sciences

A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

Article Chemistry, Multidisciplinary

Can N95 Respirators Be Reused after Disinfection? How Many Times?

Lei Liao et al.

ACS NANO (2020)

Review Materials Science, Multidisciplinary

AIE Bioconjugates for Biomedical Applications

Haixiang Liu et al.

ADVANCED OPTICAL MATERIALS (2020)

Article Biochemistry & Molecular Biology

Respiratory virus shedding in exhaled breath and efficacy of face masks

Nancy H. L. Leung et al.

NATURE MEDICINE (2020)

Article Chemistry, Multidisciplinary

A Fluorogenic Trehalose Probe for Tracking Phagocytosed Mycobacterium tuberculosis

Tingting Dai et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Review Chemistry, Multidisciplinary

Aggregation-enhanced theranostics: AIE sparkles in biomedical field

Miaomiao Kang et al.

AGGREGATE (2020)

Review Chemistry, Multidisciplinary

Design of superior phototheranostic agents guided by Jablonski diagrams

Guangxue Feng et al.

CHEMICAL SOCIETY REVIEWS (2020)

Article Chemistry, Multidisciplinary

One stone, three birds: one AIEgen with three colors for fast differentiation of three pathogens

Chengcheng Zhou et al.

CHEMICAL SCIENCE (2020)

Article Multidisciplinary Sciences

Non-aromatic annulene-based aggregation-induced emission system via aromaticity reversal process

Zheng Zhao et al.

NATURE COMMUNICATIONS (2019)

Review Microbiology

Antibiotics: past, present and future

Matthew I. Hutchings et al.

CURRENT OPINION IN MICROBIOLOGY (2019)

Article Biochemical Research Methods

A rapid and inexpensive viability assay for zoospores and zoosporangia of Batrachochytrium dendrobatidis

Rebecca Jane Webb et al.

JOURNAL OF MICROBIOLOGICAL METHODS (2019)

Article Chemistry, Multidisciplinary

Engineering Sensor Arrays Using Aggregation-Induced Emission Luminogens for Pathogen Identification

Chengcheng Zhou et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Article Biochemistry & Molecular Biology

Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy

Catherine A. McLellan et al.

NATURE CHEMICAL BIOLOGY (2018)

Review Biotechnology & Applied Microbiology

Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance

M. Rhia L. Stone et al.

TRENDS IN BIOTECHNOLOGY (2018)

Article Chemistry, Multidisciplinary

Identification of a Functionally Unique Family of Penicillin-Binding Proteins

Michael A. Welsh et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Multidisciplinary Sciences

Design and synthesis of theranostic antibiotic nanodrugs that display enhanced antibacterial activity and luminescence

Sheng Xie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Chemistry, Multidisciplinary

Two-photon AIE bio-probe with large Stokes shift for specific imaging of lipid droplets

Meijuan Jiang et al.

CHEMICAL SCIENCE (2017)

Review Public, Environmental & Occupational Health

Antibiotic resistance

Marianne Frieri et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2017)

Review Chemistry, Multidisciplinary

AIE Luminogens for Bioimaging and Theranostics: from Organelles to Animals

Jun Qian et al.

Review Chemistry, Multidisciplinary

Fluorescent Probes for Sensing and Imaging within Specific Cellular Organelles

Hao Zhu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

Review Chemistry, Multidisciplinary

Aggregation-Induced Emission: Together We Shine, United We Soar!

Ju Mei et al.

CHEMICAL REVIEWS (2015)

Article Chemistry, Multidisciplinary

Cationic Conjugated Polymers for Discrimination of Microbial Pathogens

Huanxiang Yuan et al.

ADVANCED MATERIALS (2014)

Review Microbiology

Are mitochondria the Achilles' heel of the Kingdom Fungi?

Laurent Chatre et al.

CURRENT OPINION IN MICROBIOLOGY (2014)

Review Genetics & Heredity

Recent advances in genomic DNA sequencing of microbial species from single cells

Roger S. Lasken et al.

NATURE REVIEWS GENETICS (2014)

Article Chemistry, Multidisciplinary

A Photostable AIE Luminogen for Specific Mitochondrial Imaging and Tracking

Chris Wai Tung Leung et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Review Pharmacology & Pharmacy

Antifungal Susceptibility Testing: A Primer for Clinicians

Kristi M. Kuper et al.

PHARMACOTHERAPY (2012)

Review Cell Biology

Biomaterial-Associated Infection: Locating the Finish Line in the Race for the Surface

Henk J. Busscher et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

Review Biotechnology & Applied Microbiology

Penicillin: the medicine with the greatest impact on therapeutic outcomes

Nelson Kardos et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)

Article Cell Biology

The Bacterial Cell Envelope

Thomas J. Silhavy et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Immunology

Molecular diagnostics for the detection and characterization of microbial pathogens

Gary W. Procop

CLINICAL INFECTIOUS DISEASES (2007)

Article Dermatology

Fungal infections

Roderick J. Hay

CLINICS IN DERMATOLOGY (2006)

Review Multidisciplinary Sciences

Review - The fluorescent toolbox for assessing protein location and function

BNG Giepmans et al.

SCIENCE (2006)

Review Biochemistry & Molecular Biology

Photodynamic therapy: a new antimicrobial approach to infectious disease?

MR Hamblin et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2004)

Review Biochemistry & Molecular Biology

Antibacterial resistance worldwide: causes, challenges and responses

SB Levy et al.

NATURE MEDICINE (2004)

Review Microbiology

Antifungal susceptibility testing: Practical aspects and current challenges

JH Rex et al.

CLINICAL MICROBIOLOGY REVIEWS (2001)

Article Chemistry, Multidisciplinary

Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole

JD Luo et al.

CHEMICAL COMMUNICATIONS (2001)

Review Biochemistry & Molecular Biology

Mechanisms of biofilm resistance to antimicrobial agents

TFC Mah et al.

TRENDS IN MICROBIOLOGY (2001)