Journal
CELL REPORTS
Volume 14, Issue 6, Pages 1500-1516Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2016.01.015
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Funding
- Institut Pasteur
- INSERM
- Universite Paris Diderot
- Ministere de la Recherche
- Association pour la Recherche sur le Cancer
- REVIVE Future Investment Program
- Center for Human Immunology and Cytometry platform at Institut Pasteur
- Agence Nationale de Recherche (ANR)
- Swiss National Science Foundation
- Bourse Roux
- ANR grant Myeloten''
- Institut National du Cancer
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T and innate lymphoid cells (ILCs) share some aspects of their developmental programs. However, although Notch signaling is strictly required for T cell development, it is dispensable for fetal ILC development. Constitutive activation of Notch signaling, at the common lymphoid progenitor stage, drives T cell development and abrogates ILC development by preventing Id2 expression. By combining single-cell transcriptomics and clonal culture strategies, we characterize two heterogeneous alpha(4)beta(7)-expressing lymphoid progenitor compartments. alpha LP1 (Flt3(+)) still retains T cell potential and comprises the global ILC progenitor, while alpha LP2 (Flt3(-)) consists of ILC precursors that are primed toward the different ILC lineages. Only a subset of alpha LP2 precursors is sensitive to Notch signaling required for their proliferation. Our study identifies, in a refined manner, the diversity of transitional stages of ILC development, their transcriptional signatures, and their differential dependence on Notch signaling.
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