Journal
CELL REPORTS
Volume 14, Issue 4, Pages 945-955Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2015.12.088
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Funding
- Boston University
- B. Hasso Family Foundation
- Karen and Brock Wagner family
- [NIH-R03 DK064544]
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The relationship between the host and its microbiota is challenging to understand because both microbial communities and their environments are highly variable. We have developed a set of techniques based on population dynamics and information theory to address this challenge. These methods identify additional bacterial taxa associated with pediatric Crohn disease and can detect significant changes in microbial communities with fewer samples than previous statistical approaches required. We have also substantially improved the accuracy of the diagnosis based on the microbiota from stool samples, and we found that the ecological niche of a microbe predicts its role in Crohn disease. Bacteria typically residing in the lumen of healthy individuals decrease in disease, whereas bacteria typically residing on the mucosa of healthy individuals increase in disease. Our results also show that the associations with Crohn disease are evolutionarily conserved and provide a mutual information-based method to depict dysbiosis.
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