4.4 Article

B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow

Journal

HAEMATOLOGICA
Volume 108, Issue 5, Pages 1244-1258

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FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2027.280457

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Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). Bone marrow microenvironment plays a role in treatment resistance. By using three-dimensional fluorescence imaging, specific sites in the bone marrow were identified where B-cell precursor ALL cells and T-ALL cells preferentially reside and interact with different components of the microenvironment. These lineage-dependent differences suggest potential targets for improving treatment.
Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). The bone marrow microenvironment may support escape from treatment. Using three-dimensional fluorescence imaging of ten primary ALL xenografts we identified sites of predilection in the bone marrow for resistance to induction with dexamethasone, vincristine and doxorubicin. We detected B-cell precursor ALL cells predominantly in the perisinusoidal space at early engraftment and after chemotherapy. The spatial distribution of T-ALL cells was more widespread with contacts to endosteum, nestin+ pericytes and sinusoids. Dispersion of T-ALL cells in the bone marrow increased under chemotherapeutic pressure. A subset of slowly dividing ALL cells was transiently detected upon short -term chemotherapy, but not at residual disease after chemotherapy, challenging the notion that ALL cells escape treatment by direct induction of a dormant state in the niche. These lineage-dependent differences point to niche interactions that may be more specifically exploitable to improve treatment.

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