Journal
CELL REPORTS
Volume 17, Issue 6, Pages 1595-1606Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2016.10.027
Keywords
-
Categories
Funding
- American Heart Association [14POST18340021]
- Leukemia and Lymphoma Society [5431-15, 1657-13]
- muCSD Interdisciplinary Stem Cell Training Program (CIRM) [TG2-01154]
- UCSD Stem Cell Program
- CIRM Major Facilities grant [FA1-00607]
- CIRM [RB4-06158]
Ask authors/readers for more resources
All mature blood cell types in the adult animal arise from hematopoietic stem and progenitor cells ( HSPCs). However, the developmental cues regulating HSPC ontogeny are incompletely understood. In particular, the details surrounding a requirement for Wnt/beta-catenin signaling in the development of mature HSPCs are controversial and difficult to consolidate. Using zebrafish, we demonstrate that Wnt signaling is required to direct an amplification of HSPCs in the aorta. Wnt9a is specifically required for this process and cannot be replaced by Wnt9b or Wnt3a. This proliferative event occurs independently of initial HSPC fate specification, and the Wnt9a input is required prior to aorta formation. HSPC arterial amplification occurs prior to seeding of secondary hematopoietic tissues and proceeds, in part, through the cell cycle regulator myca (c-myc). Our results support a general paradigm, in which early signaling events, including Wnt, direct later HSPC developmental processes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available