Journal
CELL REPORTS
Volume 17, Issue 2, Pages 336-344Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2016.09.028
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Funding
- National Eye Institute [EY008117]
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Drosophila third-instar larvae exhibit changes in their behavioral responses to gravity and food as they transition from feeding to wandering stages. Using a thermal gradient encompassing the comfortable range (18 degrees C to 28 degrees C), we found that third-instar larvae exhibit a dramatic shift in thermal preference. Early third-instar larvae prefer 24 degrees C, which switches to increasingly stronger biases for 18 degrees C-19 degrees C in mid- and late-third-instar larvae. Mutations eliminating either of two rhodopsins, Rh5 and Rh6, wiped out these age-dependent changes in thermal preference. In larvae, Rh5 and Rh6 are thought to function exclusively in the light-sensing Bolwig organ. However, the Bolwig organ was dispensable for the thermal preference. Rather, Rh5 and Rh6 were required in trpA1-expressing neurons in the brain, ventral nerve cord, and body wall. Because Rh1 contributes to thermal selection in the comfortable range during the early to mid-third-instar stage, fine thermal discrimination depends on multiple rhodopsins.
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