Journal
CELL REPORTS
Volume 16, Issue 4, Pages 1166-1179Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2016.06.051
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Funding
- Helse Sor-Ost [2012056]
- Norwegian Cancer Society [420056]
- Oslo University Hospital
- K.G. Jebsen Centre for Breast Cancer Research
- United States Department of Defense [W81XWH-10-1-0299]
- McGill University Faculty of Medicine
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
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Breast cancer consists of at least five main molecular intrinsic'' subtypes that are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of invasive breast cancer are established early, it is unclear what mechanisms drive progression and whether the mechanisms of progression are dependent or independent of subtype. We have generated mRNA, miRNA, and DNA copy-number profiles from a total of 59 in situ lesions and 85 invasive tumors in order to comprehensively identify those genes, signaling pathways, processes, and cell types that are involved in breast cancer progression. Our work provides evidence that there are molecular features associated with disease progression that are unique to the intrinsic subtypes. We additionally establish subtype-specific signatures that are able to identify a small proportion of pre-invasive tumors with expression profiles that resemble invasive carcinoma, indicating a higher likelihood of future disease progression.
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