Journal
CELL REPORTS
Volume 16, Issue 7, Pages 1962-1973Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2016.07.021
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Funding
- MRC UK
- Rosetrees Trust
- MRC [MR/K005537/1] Funding Source: UKRI
- Medical Research Council [MR/K005537/1] Funding Source: researchfish
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Here, we uncover a mechanism for regulating the number of active presynaptic GABA(B) receptors GABA(B)Rs) at nerve terminals, an important determinant of neurotransmitter release. We find that GABA(B)Rs gain access to axon terminals by lateral diffusion in the membrane. Their relative accumulation is dependent upon agonist activation and the presence of the two distinct sushi domains that are found only in alternatively spliced GABA(B)R1a subunits. Following brief activation of NMDA receptors NMDARs) using glutamate, GABA(B)R diffusion is reduced, causing accumulation at presynaptic terminals in a Ca2+-dependent manner that involves phosphorylation of GABA(B)R2 subunits at Ser783. This signaling cascade indicates how synaptically released glutamate can initiate, via a feedback mechanism, increased levels of presynaptic GABA(B)Rs that limit further glutamate release and excitotoxicity.
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