Journal
CHEMICAL COMMUNICATIONS
Volume 59, Issue 49, Pages 7615-7618Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3cc01239e
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A Cas12a platform programmed by split G-quadruplex (G4) was established, validated, and optimized, which utilized split G4 motif as a substrate and demonstrated a concentration-dependent response to the input target in a label-free sensing platform. Moreover, the platform successfully detected and profiled exosomal surface proteins from cultured cancer cells and clinical samples.
A split G-quadruplex (G4)-programmed Cas12a platform was established, validated, and optimized. The split G4 motif was recruited as substrate for Cas12a, and the label-free sensing platform provided a concentration-dependent response towards the input target. Furthermore, exosomal surface proteins from cultured cancer cells and clinical samples were detected and profiled.
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