A two-step lighting DNA tetrahedral nanoprobe for precise imaging-guided photodynamic therapy of tumors

Article Chemistry, Analytical

Membrane Protein and Extracellular Acid Heterogeneity-Driven Amplified DNA Logic Gate Enables Accurate and Sensitive Identification of Cancer Cells

Biao Chen et al.

Summary: This research report presents a membrane protein and extracellular acid heterogeneity-driven amplified DNA logic gate (HDLG) for accurate and sensitive identification of cancer cells. The HDLG combines the signal amplification characteristics of the hybridization chain reaction (HCR) and the precise computation ability of the logic operation.

ANALYTICAL CHEMISTRY (2022)

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Article Nanoscience & Nanotechnology

Liposome-Based Nanoencapsulation of a Mitochondria-Stapling Photosensitizer for Efficient Photodynamic Therapy

Mingyu Tian et al.

Summary: This study developed a smart liposome encapsulation method based on a mitochondria-stapling photosensitizer for efficient theranostic photodynamic therapy. The nanophotosensitizer can stay inside mitochondria without falling off, regardless of the change of mitochondrial membrane potential. It showed high efficiency of PDT and had fluorescence imaging-guided ability.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Analytical

DNA Logic Nanodevices for the Sequential Imaging of Cancer Markers through Localized Catalytic Hairpin Assembly Reaction

Li Li Li et al.

Summary: A DNA nanodevice with logic-responsive and signal amplifying capability has been developed for sequential imaging of tumor biomarkers in cells. The nanodevice shows better molecular targeting and recognition ability, making it useful for early cancer diagnosis and cell identification.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Specific Activation of Photosensitizer with Extrinsic Enzyme for Precisive Photodynamic Therapy

Junlong Xiong et al.

Summary: This study presents a novel bioconjugation strategy for the selective delivery of modified enzymes into cancer cells, enabling the activation of photosensitizers for therapeutic applications. The activation of photosensitizers inside the cancer cells resulted in cell death, demonstrating the potential of this approach for efficient photodynamic therapy.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Review Pharmacology & Pharmacy

Cell-based drug delivery systems and their in vivo fate

Liuxin Yang et al.

Summary: Cell-based drug delivery systems have gained attention for their unique biological properties and self-powered functions. They exhibit excellent biocompatibility, low immunogenicity, long circulation time, tissue-homing characteristics, and the ability to cross biological barriers. Various cells have been explored as functional vectors for loading and delivering therapeutic payloads, showing potential for disease treatment. The fate of these cell-based drug delivery systems in vivo depends on biological properties, loaded drugs, physiological and pathological circumstances, and the body's response.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Review Chemistry, Multidisciplinary

Research progress on tumor hypoxia-associative nanomedicine

Xiao-Xue Xu et al.

Summary: Hypoxia at the tumor site is closely related to tumor progression and treatment resistance. Hypoxia-associa-tive nanomedicine has been proposed as a potential solution for tumor treatment. This review summarizes the design principles, applications, and limitations of hypoxia-associa-tive nanomedicine in recent years, as well as explores its development trends in the treatment of solid tumors.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Immunology

Clinical cancer immunotherapy: Current progress and prospects

Chenglong Liu et al.

Summary: Immune checkpoint therapy utilizing PD-1 antibodies has demonstrated significant clinical value and therapeutic potential, although it is not without limitations such as immune-related adverse events, cytokine storm, and low response rates. This review discusses the basic classification, research progress, and limitations of cancer immunotherapy, as well as providing insights into the development of new anticancer immunotherapy strategies through the analysis of resistance mechanisms and combination therapy.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Nanoscience & Nanotechnology

Reductase and Light Programmatical Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of Biomolecules in Subcellular Organelles under Hypoxic Conditions

Jin Liu et al.

Summary: Monitoring hypoxia-related changes in subcellular organelles has been facilitated by a new nanodevice incorporating light-responsive DNA probes into a hypoxia-responsive metal-organic framework, enabling spatiotemporally controlled imaging of biomolecules. This approach shows promise for monitoring dynamic changes in subcellular organelles under hypoxic conditions.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary