4.5 Article

Transannular Functionalization of Multiple C(sp3)-H Bonds of Tropane via an Alkene-Bridged Palladium(I) Dimer

Journal

ORGANOMETALLICS
Volume 42, Issue 8, Pages 627-631

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.3c00086627

Keywords

-

Ask authors/readers for more resources

This study describes the Pd-catalyzed C(sp(3))-H functionalization of a tropane derivative, resulting in products with functionalization at two or three different sites on the alicyclic amine core. The reaction involves dehydrogenation to generate an alkene product, which can further react to form a Pd(I) alkene-bridged dimer. Functionalization of this dimer produces ss/./ss-functionalized allylic arylation and allylic acetoxylation products.
This Communication describes the Pd-catalyzed C(sp(3))-H functionalization of a tropane derivative to generate products with functionalization at two (ss/gamma) or three (ss/gamma/ss) different sites on the alicyclic amine core. These reactions proceed via an initial dehydrogenation to generate an alkene product that can react further to form a Pd(I) alkene-bridged dimer. Functionalization of this dimer affords ss/./ss-functionalized allylic arylation and allylic acetoxylation products

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available