Journal
CANCER RESEARCH AND TREATMENT
Volume 48, Issue 4, Pages 1443-1447Publisher
KOREAN CANCER ASSOCIATION
DOI: 10.4143/crt.2016.096
Keywords
Hepatic veno-occlusive disease; Rhabdomyosarcoma; Defibrotide
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Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening syndrome that generally occurs as a complication after hematopoietic stem cell transplantation or, less commonly, after conventional chemotherapy. Regarding SOS in rhabdomyosarcoma patients who received conventional chemotherapy, the doses of chemotherapeutic agents are associated with the development of SOS. Several cases of SOS in rhabdomyosarcoma patients after receiving chemotherapy with escalated doses of cyclophosphamide have been reported. Here, we report on a 9-year-old female with rhabdomyosarcoma who developed severe SOS after receiving chemotherapy consisting of vincristine, actinomycin-D, and a moderate dose of cyclophosphamide. She was treated successfully with defibrotide without sequelae to the liver.
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