Journal
BMJ-BRITISH MEDICAL JOURNAL
Volume 354, Issue -, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/bmj.i4515
Keywords
-
Categories
Funding
- Medical Research Council [MR/L009005/1]
- Medical Research Council [MR/L009005/1, G0802403] Funding Source: researchfish
- MRC [MR/L009005/1, G0802403] Funding Source: UKRI
Ask authors/readers for more resources
The self controlled case series (SCCS) method is an epidemiological study design for which individuals act as their own control-ie, comparisons are made within individuals. Hence, only individuals who have experienced an event are included and all time invariant confounding is eliminated. The temporal association between a transient exposure and an event is estimated. SCCS was originally developed for evaluation of vaccine safety, but has since been applied in a range of settings where exact information on the size of the population at risk is lacking or identification of an appropriate comparison group is difficult-eg, for studies of adverse effects of drug treatments. We provide an overview of the SCCS method, with examples of its use, discuss limitations, assumptions, and potential biases that can arise where assumptions are not met, and provide solutions and examples of good practice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available