Sex Differences in the Pharmacokinetics of Cannabidiol and Metabolites Following Oral Administration of a Cannabidiol-Dominant Cannabis Oil in Healthy Adults

Article Pharmacology & Pharmacy

Pharmacokinetics of cannabichromene in a medical cannabis product also containing cannabidiol and Δ9-tetrahydrocannabinol: a pilot study

Erica N. Peters et al.

Summary: This study suggests that when administered together, cannabichromene (CBC) may have preferential absorption over cannabidiol (CBD) and Delta(9)-tetrahydrocannabinol (THC).

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2022)

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Article Chemistry, Analytical

Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Yellow Oil in Healthy Participants

Erica N. Peters et al.

Summary: This study evaluated the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of Spectrum Yellow oil, a cannabis product used for medical purposes. The results showed that Spectrum Yellow oil had good safety and tolerability at appropriate doses, with steady-state plasma CBD concentrations reached within 7 days.

JOURNAL OF ANALYTICAL TOXICOLOGY (2022)

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Article Nutrition & Dietetics

Cannabidiol (CBD) Dosing: Plasma Pharmacokinetics and Effects on Accumulation in Skeletal Muscle, Liver and Adipose Tissue

Robert B. Child et al.

Summary: This study investigated the pharmacokinetics and tissue accumulation of orally consumed CBD in adult rats. The results showed that CBD levels were higher in adipose tissue compared to liver and muscle, and there was a moderate correlation between CBD levels in adipose and muscle tissue. CBD feeding also resulted in gender-specific effects and alterations in pharmacokinetics.

NUTRIENTS (2022)

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Article Pharmacology & Pharmacy

Use and Perceptions of Cannabidiol Products in Canada and in the United States

Samantha Goodman et al.

Summary: CBD product use is more prevalent in the United States than in Canada, primarily for managing self-reported health conditions such as pain, anxiety, and depression. Over half of consumers believe that CBD oil is beneficial for health.

CANNABIS AND CANNABINOID RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Sex differences in the acute effects of oral and vaporized cannabis among healthy adults

Dennis J. Sholler et al.

Summary: Research comparing the acute effects of oral and vaporized cannabis in occasional users found that females exhibited stronger drug effects in some aspects, especially when controlling for body weight. Recommendations include starting with lower doses for females and being aware of potential acute anxiogenic reactions when using cannabinoids.

ADDICTION BIOLOGY (2021)

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Article Pharmacology & Pharmacy

Cytochrome P450-Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol

Jessica L. Beers et al.

Summary: This study demonstrates that both CYP2C19 and CYP2C9 play important roles in CBD metabolism to the active metabolite 7-OH-CBD, while CYP3A4 contributes significantly to CBD metabolism through pathways other than 7-hydroxylation. Formation of 7-OH-CBD is correlated with human liver microsomal CYP2C19 activity, but not CYP2C19 genotype, and CYP2C9 was found to have a significant contribution to 7-OH-CBD generation.

DRUG METABOLISM AND DISPOSITION (2021)

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Review Pharmacology & Pharmacy

The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives

Yue Zu et al.

Summary: Excessive estrogens can lead to intrahepatic cholestasis, resulting in liver injury and adverse pregnancy outcomes. The main pathogenic mechanisms include abnormalities in BA synthetic or metabolic enzymes and cell membrane fluidity.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Neurosciences