☆ 4.8 Review

Glycomimetics for the inhibition and modulation of lectins

CHEMICAL SOCIETY REVIEWS (2023)

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Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1

Sander F. Garrelfs et al.

Summary: Primary hyperoxaluria type 1 is a rare genetic disease caused by hepatic overproduction of oxalate, leading to kidney stones, nephrocalcinosis, kidney failure, and systemic oxalosis. This trial tested the efficacy of lumasiran, an RNAi therapeutic agent, in reducing hepatic oxalate production. The results showed that lumasiran significantly reduced urinary oxalate excretion, alleviating the cause of kidney failure in PH1 patients.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Microbiology

Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core

Dagmara Kisiela et al.

Summary: The study identified a novel antibody that acts as a kinetic trap to prevent the conformational transitions of FimH protein, leading to a significant slowing down of its ability to bind mannose and blocking bacterial adhesion. Residues Leu-34 and Val-35 of FimH were found to act as molecular toggle switches, which, when disrupted, hinder the conformational transition and adhesive function of the protein. The research also demonstrated that the allosteric switches are conserved across a diverse family of bacterial fimbrial adhesins.

PLOS PATHOGENS (2021)

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Article Oncology

Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor

Brendan D. Curti et al.

Summary: Combination therapy of belapectin and pembrolizumab shows promising activity in patients with metastatic melanoma and head and neck squamous cell carcinoma, with increased activation of effector memory T cells and decreased levels of monocytic myeloid-derived suppressor cells observed in responders. Additionally, increased expression of Gal-3, PD-1+CD8+ T cells, and higher serum trough levels of pembrolizumab are correlated with treatment response, indicating potential biomarkers for clinical outcomes.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Biochemistry & Molecular Biology

Tolerogenic Nanoparticles Impacting B and T Lymphocyte Responses Delay Autoimmune Arthritis in K/BxN Mice

Amrita Srivastava et al.

Summary: Current treatments for unwanted antibody responses often rely on immunosuppressive drugs which compromise overall immunity. New nanoparticle-based approaches, such as Siglec-engaging tolerance-inducing antigenic liposomes (STALs) and poly(lactic-co-glycolic acid)-rapamycin nanoparticles (PLGA-R), have shown promise in inducing antigen-specific tolerance and may work synergistically when used in combination. These methods have demonstrated robust tolerance to multiple antigens in naive mice and delayed the onset of autoimmune diseases in mouse models.

ACS CHEMICAL BIOLOGY (2021)

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Review Chemistry, Organic

Chemical and Biophysical Approaches to Allosteric Modulation

Monica Civera et al.

Summary: Allosteric regulation, the control exerted on a main site by an effector at a distant site, is a precise tuning system for key biological processes such as gene transcription and signal transduction. Extensively studied since its discovery sixty years ago, this article introduces the topic of protein allostery, outlining models and approaches, and providing case studies representing different protein classes.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2021)

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Review Pharmacology & Pharmacy

Evolution of the drug-target residence time model

Robert A. Copeland

Summary: The drug-target residence time model provides a theoretical framework for understanding the complexities of in vivo drug action. By combining in vitro measured residence time, equilibrium measures of drug-target affinity, and in vivo measures of pharmacokinetic half-life, researchers can have a powerful approach to optimize drugs for clinical effect. Further studies are needed to better understand the dynamic interplay between residence time, target pathobiology, drug distribution, and drug pharmacokinetics despite the significant use and refinement of this model.

EXPERT OPINION ON DRUG DISCOVERY (2021)

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Article Biochemistry & Molecular Biology

Bifunctional small molecules that mediate the degradation of extracellular proteins

David F. Caianiello et al.

Summary: Targeted protein degradation (TPD) is a promising therapeutic strategy, with MoDE-A technology enabling degradation of extracellular proteins. Experimental evidence shows the modularity of MoDE-A molecules in inducing specific protein depletion, opening up new possibilities for disease treatment.

NATURE CHEMICAL BIOLOGY (2021)

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Editorial Material Urology & Nephrology

A new era of treatment for primary hyperoxaluria type 1

Florian Erger et al.

Summary: New data from the ILLUMINATE-A trial demonstrate the safety and efficacy of lumasiran in patients with primary hyperoxaluria type 1. Further studies are needed to investigate the potential long-term benefits of this promising therapy.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Microbiology

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

Michel Thepaut et al.

Summary: The study reveals that C-type lectin receptors (CLRS) can bind to the spike envelope protein of SARS-CoV-2, and DC-SIGN and L-SIGN among them can promote virus trans-infection. This discovery identifies a new mechanism for enhancing viral spread.

PLOS PATHOGENS (2021)

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Article Microbiology

Targeting human langerin promotes HIV-1 specific humoral immune responses

Jerome Kervevan et al.

Summary: Targeting of skin Langerhans cells (LC) may efficiently induce potent anti-HIV immune responses, serving as a promising strategy for developing effective HIV-1 vaccines. This approach demonstrates the potential of directing immune responses through specific cell targeting and may lead to the induction of protective antibodies against HIV-1.

PLOS PATHOGENS (2021)

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Article Microbiology

Small-Molecule Inhibition of Viral Fusion Glycoproteins

Han-Yuan Liu et al.

Summary: Viral fusion glycoproteins catalyze membrane fusion through regulated changes in conformation, recent advances in knowledge have enabled the development of small-molecule inhibitors for probing viral glycoprotein-mediated fusion mechanisms.

ANNUAL REVIEW OF VIROLOGY, VOL 8 (2021)

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Article Microbiology

Blockage of bacterial FimH prevents mucosal inflammation associated with Crohn's disease

Gregoire Chevalier et al.

Summary: The study identified a significant enrichment of FimH-expressing bacteria in the gut microbiome of CD patients, with FimH playing a crucial role in adhesion and inflammation induction. The specific FimH-blocker TAK-018 was shown to prevent bacterial adhesion and inflammation, potentially offering a promising treatment option for CD patients.

MICROBIOME (2021)

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Article Chemistry, Multidisciplinary

CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2

Razie Amraei et al.

Summary: The study identified CD209L and CD209 as receptors for SARS-CoV-2 entry into human cells. CD209L is prominently expressed in lung and kidney tissues and interacts with ACE2, potentially playing a role in SARS-CoV-2 infection. This finding may have implications for antiviral drug development in tissues where ACE2 expression is low or absent.

ACS CENTRAL SCIENCE (2021)

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Review Chemistry, Multidisciplinary

Towards the sustainable discovery and development of new antibiotics

Marcus Miethke et al.

Summary: There is a growing demand for novel antimicrobials to treat infections caused by multidrug-resistant bacterial pathogens, but there is currently a lack of investment in this field. New agents with innovative chemistry and modes of action are urgently needed to combat the public health threat posed by antimicrobial resistance. The consortium proposes short-term and long-term solutions to overcome urgent limitations in research and funding, aiming to bridge the gap between academic, industrial, and political stakeholders to improve the ability to discover and develop new antibiotics.

NATURE REVIEWS CHEMISTRY (2021)

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Review Chemistry, Multidisciplinary

Liver-Targeted Delivery of Oligonucleotides with N-Acetylgalactosamine Conjugation

Hao Cui et al.

Summary: The potential therapeutic application of oligonucleotides that selectively suppress target genes through antisense and RNA interference mechanisms has attracted widespread attention, with a focus on liver-targeted delivery using N-acetylgalactosamine (GalNAc) ligands. Recent progress in the field of GalNAc conjugates for improving cellular uptake and tissue-specific delivery has shown promising results in preclinical and clinical trials.

ACS OMEGA (2021)

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Review Biochemistry & Molecular Biology

Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN

Jonathan Cramer

Summary: Myeloid C-type lectin receptors (CLRs) play important roles in immunity, homeostasis, and cancer as pattern-recognition receptors on cells of the innate immune system. As appealing targets for therapeutic interventions, research into glycomimetic or drug-like small molecule ligands for CLRs Mincle, Langerin, and DC-SIGN shows potential applications in vaccine research and anti-infective therapy.

RSC MEDICINAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa

Elena Shanina et al.

Summary: The study utilized PrOF NMR to successfully detect ligands binding to LecA, providing a valuable approach for the development of LecA inhibitors in future drug discovery campaigns.

GLYCOBIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Carbohydrate Systems in Targeted Drug Delivery: Expectation and Reality

E. S. Shchegravina et al.

Summary: The review explores the use of carbohydrates in targeted drug delivery, focusing on their potential applications in the treatment of oncological diseases. Carbohydrates have been shown to serve as effective vector ligands for targeted drug delivery and therapy.

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY (2021)

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Review Chemistry, Medicinal

Design and synthesis of glycomimetics: Recent advances

Alice Tamburrini et al.

MEDICINAL RESEARCH REVIEWS (2020)

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Review Chemistry, Multidisciplinary

New Promise and Opportunities for Allosteric Kinase Inhibitors

Xiaoyun Lu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

The 3F Library: Fluorinated Fsp3-Rich Fragments for Expeditious 19F NMR Based Screening

Nikolaj S. Troelsen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Immunology

Siglecs as Immune Cell Checkpoints in Disease

Shiteng Duan et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

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Article Gastroenterology & Hepatology

Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension

Naga Chalasani et al.

GASTROENTEROLOGY (2020)

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Article Biochemistry & Molecular Biology

Functional binding of E-selectin to its ligands is enhanced by structural features beyond its lectin domain

Fajr A. Aleisa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Review Cell Biology

Don't sugarcoat it: How glycocalyx composition influences cancer progression

Alexander Buffone et al.

JOURNAL OF CELL BIOLOGY (2020)

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Review Chemistry, Multidisciplinary

A glance over doxorubicin based-nanotherapeutics: From proof-of-concept studies to solutions in the market

Mara Goncalves et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Immunology

Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression

Maria Romina Girotti et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Review Microbiology

Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies

Roger D. Klein et al.

NATURE REVIEWS MICROBIOLOGY (2020)

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Article Chemistry, Medicinal

Epimers Switch Galectin-9 Domain Selectivity: 3N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal

Mukul Mahanti et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

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Review Biochemistry & Molecular Biology

Molecular Recognition in C-Type Lectins: The Cases of DC-SIGN, Langerin, MGL, and L-Sectin

Pablo Valverde et al.

CHEMBIOCHEM (2020)

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Review Chemistry, Organic

Probing Sialidases or Siglecs with Sialic Acid Analogues, Clusters and Precursors

Guang-jian Liu et al.

ASIAN JOURNAL OF ORGANIC CHEMISTRY (2020)

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Article Microbiology

The Pseudomonas aeruginosa Lectin LecB Causes Integrin Internalization and Inhibits Epithelial Wound Healing

Roland Thuenauer et al.

MBIO (2020)

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Article Multidisciplinary Sciences

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

Valerie Barbier et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Discovery of a new sialic acid binding region that regulates Siglec-7

Nao Yamakawa et al.

SCIENTIFIC REPORTS (2020)

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Article Medicine, Research & Experimental

Less Is More: Novel Hepatocyte-Targeted siRNA Conjugates for Treatment of Liver-Related Disorders

Adrien Weingaertner et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Medicine, General & Internal

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol

Kausik K. Ray et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia

Frederick J. Raal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Pharmacology & Pharmacy

Lipid-based nanoparticle technologies for liver targeting

Roland Boettger et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Rational Design of a DNA-Scaffolded High-Affinity Binder for Langerin

Gunnar Bachem et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Biochemistry & Molecular Biology

Allostery in C-type lectins

Bettina G. Keller et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2020)

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Review Chemistry, Multidisciplinary

Targeting Galectins With Glycomimetics

Sara Bertuzzi et al.

FRONTIERS IN CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state

Gisela Schnapp et al.

COMMUNICATIONS CHEMISTRY (2020)

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Article Biology

Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor

Aleksandar Antanasijevic et al.

LIFE SCIENCE ALLIANCE (2020)

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Review Biotechnology & Applied Microbiology

Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug

Alexandre J. Debacker et al.

MOLECULAR THERAPY (2020)

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Article Multidisciplinary Sciences

Lysosome-targeting chimaeras for degradation of extracellular proteins

Steven M. Banik et al.

NATURE (2020)

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Article Multidisciplinary Sciences

An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen

Yao Yao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Environmental Sciences

Digoxin: Pharmacology and toxicology-A review

Jiri Patocka et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2020)

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Article Chemistry, Medicinal

Insights into the Loop at the E-Selectin Binding Site: From Open to Close Conformation

Xiaocong Wang et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)

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Article Chemistry, Medicinal

Rational Design and Synthesis of Methyl-β-D-galactomalonyl Phenyl Esters as Potent Galectin-8N Antagonists

Brijesh Patel et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Chemistry, Medicinal

Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa

Joscha Meiers et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Review Immunology

Utilization of Galectins by Pathogens for Infection

Diyoly Ayona et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Cell Biology

Current Status on Therapeutic Molecules Targeting Siglec Receptors

Maria Pia Lenza et al.

CELLS (2020)

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Article Chemistry, Multidisciplinary

Fucosylated ubiquitin and orthogonally glycosylated mutant A28C: conceptually new ligands for Burkholderia ambifaria lectin (BambL)

Sakonwan Kuhaudomlarp et al.

CHEMICAL SCIENCE (2020)

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Review Biochemistry & Molecular Biology

Galectin-8 in the onset of the immune response and inflammation

Maria Tribulatti et al.

GLYCOBIOLOGY (2020)

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Review Biochemistry & Molecular Biology

PROTACs: An Emerging Therapeutic Modality in Precision Medicine

Dhanusha A. Nalawansha et al.

CELL CHEMICAL BIOLOGY (2020)

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Article Chemistry, Multidisciplinary

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps fromd-galactose pentaacetate

Eva Zahorska et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Synthesis of tricyclic carbohydrate-benzene hybrids as selective inhibitors of galectin-1 and galectin-8 N-terminal domains

Chunxia Wu et al.

RSC ADVANCES (2020)

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Article Chemistry, Medicinal

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors

Sharan K. Bagal et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Article Chemistry, Medicinal

Improvement of Aglycone π-Stacking Yields Nanomolar to Sub-nanomolar FimH Antagonists

Wojciech Schonemann et al.

CHEMMEDCHEM (2019)

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Article Chemistry, Organic

Assembly of Divalent Ligands and Their Effect on Divalent Binding to Pseudomonas aeruginosa Lectin LecA

Guangyun Yu et al.

JOURNAL OF ORGANIC CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

Multivalent Recognition at Fluid Surfaces: The Interplay of Receptor Clustering and Superselectivity

Galina V. Dubacheva et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Biochemistry & Molecular Biology

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

Jun Wang et al.

NATURE MEDICINE (2019)

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Review Urology & Nephrology

Glycosylation in health and disease

Colin Reily et al.

NATURE REVIEWS NEPHROLOGY (2019)

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Article Multidisciplinary Sciences

A small-molecule fusion inhibitor of influenza virus is orally active in mice

Maria J. P. van Dongen et al.

SCIENCE (2019)

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Article Biochemistry & Molecular Biology

Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins

Isabel Wilhelm et al.

SCIENCE SIGNALING (2019)

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Article Virology

Virus recognition of glycan receptors

Andrew J. Thompson et al.

CURRENT OPINION IN VIROLOGY (2019)

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Article Chemistry, Organic

Stereo- and regioselective hydroboration of 1-exo-methylene pyranoses: discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors

Alexander Dahlqvist et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing Cells

Jessica Schulze et al.

BIOCHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

Stereoselective Synthesis of Fluorinated Galactopyranosides as Potential Molecular Probes for Galactophilic Proteins: Assessment of Monofluorogalactoside-LecA Interactions

Vincent Denavit et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

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Article Oncology

Galectin-1 inhibition induces cell apoptosis through dual suppression of CXCR4 and Ras pathways in human malignant peripheral nerve sheath tumors

Tsung-Chieh Shih et al.

NEURO-ONCOLOGY (2019)

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Article Chemistry, Multidisciplinary

A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting

Eike-Christian Wamhoff et al.

ACS CENTRAL SCIENCE (2019)

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Article Chemistry, Medicinal

Enhanced Inhibition of Influenza A Virus Adhesion by Di- and Trivalent Hemagglutinin Inhibitors

Wenjing Lu et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis

Laura Medve et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

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Article Biochemistry & Molecular Biology

A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1

Kumar Bhaskar Pal et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Chemistry, Medicinal

Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure-Activity Relationship Study of C-Glycosidic LecB Inhibitors

Roman Sommer et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and -F on Immune Cells

Corwin M. Nycholat et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Multidisciplinary Sciences

Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site

Joel B. Heim et al.

SCIENTIFIC REPORTS (2019)

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Review Biochemistry & Molecular Biology

Lectin antagonists in infection, immunity, and inflammation

Joscha Meiers et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2019)

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Article Chemistry, Medicinal

Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design

Amarendar Reddy Maddirala et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

Binding of the Bacterial Adhesin FimH to Its Natural, Multivalent High-Mannose Type Glycan Targets

Maximilian M. Sauer et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Review Microbiology

Host and viral determinants of influenza A virus species specificity

Jason S. Long et al.

NATURE REVIEWS MICROBIOLOGY (2019)

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Review Chemistry, Multidisciplinary

Allosteric Methods and Their Applications: Facilitating the Discovery of Allosteric Drugs and the Investigation of Allosteric Mechanisms

Shaoyong Lu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Exploiting CD22 To Selectively Tolerize Autoantibody Producing B-Cells in Rheumatoid Arthritis

Kyle J. Bednar et al.

ACS CHEMICAL BIOLOGY (2019)

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Article Cell Biology

Langerhans Cells Orchestrate the Protective Antiviral Innate Immune Response in the Lymph Node

Eric Wong et al.

CELL REPORTS (2019)

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Review Chemistry, Multidisciplinary

The Structural Biology of Galectin-Ligand Recognition: Current Advances in Modeling Tools, Protein Engineering, and Inhibitor Design

Carlos P. Modenutti et al.

FRONTIERS IN CHEMISTRY (2019)

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Review Engineering, Multidisciplinary

Bioisosteres of Carbohydrate Functional Groups in Glycomimetic Design

Rachel Hevey

BIOMIMETICS (2019)

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Article Biochemistry & Molecular Biology

Targeted Delivery of Antigen to Activated CD169+ Macrophages Induces Bias for Expansion of CD8+ T Cells

Landon J. Edgar et al.

CELL CHEMICAL BIOLOGY (2019)

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Article Multidisciplinary Sciences

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis

Luke A. Miles et al.

ISCIENCE (2019)

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Review Chemistry, Medicinal

Strategies for the Development of Glycomimetic Drug Candidates

Rachel Hevey

PHARMACEUTICALS (2019)

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Review Pharmacology & Pharmacy

Advances in Receptor-Mediated, Tumor-Targeted Drug Delivery

Danielle E. Large et al.

ADVANCED THERAPEUTICS (2019)

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Article Biochemistry & Molecular Biology

Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system

Said Rabbani et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article Immunology

Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens

Fernando Spiller et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Chemistry, Medicinal

Synthesis and evaluation of thiomannosides, potent and orally active FimH inhibitors

Jitendra A. Sattigeri et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

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Review Biotechnology & Applied Microbiology

Recent advances in enhanced enzyme activity, thermostability and secretion by N-glycosylation regulation in yeast

Fei Ge et al.

BIOTECHNOLOGY LETTERS (2018)

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Article Chemistry, Medicinal

Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-pi, and Halogen Bond Interactions

Fredrik R. Zetterberg et al.

CHEMMEDCHEM (2018)

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Article Chemistry, Medicinal

Structure-Based Design of a Monosaccharide Ligand Targeting Galectin-8

Mohammad H. Bohari et al.

CHEMMEDCHEM (2018)

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Review Pharmacology & Pharmacy

Discovery of hidden allosteric sites as novel targets for allosteric drug design

Shaoyong Lu et al.

DRUG DISCOVERY TODAY (2018)

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Review Biochemistry & Molecular Biology

Dissecting the Structure-Activity Relationship of Galectin-Ligand Interactions

Yi-Chen Chan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Chemistry, Multidisciplinary

Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa

Roman Sommer et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Review Biochemistry & Molecular Biology

Targeting Dynamical Binding Processes in the Design of Non-Antibiotic Anti-Adhesives by Molecular Simulation-The Example of FimH

Eva-Maria Krammer et al.

MOLECULES (2018)

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Article Biochemistry & Molecular Biology

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

Matthew R. Hassler et al.

NUCLEIC ACIDS RESEARCH (2018)

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Article Multidisciplinary Sciences

Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection

Vasilios Kalas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Biochemistry & Molecular Biology

Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense

Roman Sommer et al.

STRUCTURE (2018)

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Review Biochemistry & Molecular Biology

Clinical Trials and Applications of Galectin Antagonists

Armand Girard et al.

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY (2018)

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Review Virology

Drug Delivery Strategies for Antivirals against Hepatitis B Virus

Latavia Singh et al.

VIRUSES-BASEL (2018)

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Article Chemistry, Multidisciplinary

The price of flexibility - a case study on septanoses as pyranose mimetics

Christoph P. Sager et al.

CHEMICAL SCIENCE (2018)

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Article Multidisciplinary Sciences

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

Maja M. Janas et al.

NATURE COMMUNICATIONS (2018)

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Article Chemistry, Multidisciplinary

Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands

Kristoffer Peterson et al.

RSC ADVANCES (2018)

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Article Chemistry, Medicinal

Virtual Screening Against Carbohydrate-Binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin

Tamir Dingjan et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2018)

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Review Chemistry, Multidisciplinary

Development of Mannopyranoside Therapeutics against Adherent-Invasive Escherichia coli Infections

Leila Mousavifar et al.

ACCOUNTS OF CHEMICAL RESEARCH (2018)

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Article Biochemistry & Molecular Biology

CellFy: A Cell-Based Fragment Screen against C-Type Lectins

Jessica Schulze et al.

ACS CHEMICAL BIOLOGY (2018)

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Review Chemistry, Organic

Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections

Matthew B. Calvert et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2018)

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Article Chemistry, Organic

Synthesis and Evaluation of 1,5-Dithia-D-Iaminaribiose, Triose, and Tetraose as Truncated β-(1→ 3)-Glucan Mimetics

Xiaoxiao Liao et al.

JOURNAL OF ORGANIC CHEMISTRY (2018)

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Binding Kinetics Survey of the Drugged Kinome

Victoria Georgi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Allosteric Inhibition of a Mammalian Lectin

Jonas Aretz et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Review Immunology

C-type lectins in immunity and homeostasis

Gordon D. Brown et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Meeting Abstract Hematology

A Novel and Potent Inhibitor of E-Selectin, GMI-1687, Attenuates Thrombus Formation and Augments Chemotherapeutic Intervention of AML in Preclinical Models Following Subcutaneous Administration

John Peterson et al.

BLOOD (2018)

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Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations

Jonathan B. Baell et al.

ACS CHEMICAL BIOLOGY (2018)

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Well-Defined Multivalent Ligands for Hepatocytes Targeting via Asialoglycoprotein Receptor

Xiangang Huang et al.

BIOCONJUGATE CHEMISTRY (2017)

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C-type lectins: their network and roles in pathogen recognition and immunity

Sabine Mayer et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2017)

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Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn's disease

Laurel K. Mydock-McGrane et al.

EXPERT OPINION ON DRUG DISCOVERY (2017)

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Review Pharmacology & Pharmacy

The potential of FimH as a novel therapeutic target for the treatment of Crohn's disease

Adeline Sivignon et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2017)

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Letter Allergy

Exploiting CD22 on antigen-specific B cells to prevent allergy to the major peanut allergen Ara h 2

Kelly A. Orgel et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Immunology

Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model

Kyle J. Bednar et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Chemistry, Medicinal

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo(2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Dustin Siegel et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Article Chemistry, Multidisciplinary

Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA

Mark K. Schlegel et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Article Chemistry, Multidisciplinary

CD22 Ligands on a Natural N-Glycan Scaffold Efficiently Deliver Toxins to B-Lymphoma Cells

Wenjie Peng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Article Chemistry, Multidisciplinary

Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor

Carlos A. Sanhueza et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Article Oncology

A Novel Galectin-1 Inhibitor Discovered through One-Bead Two-Compound Library Potentiates the Antitumor Effects of Paclitaxel in vivo

Tsung-Chieh Shih et al.

MOLECULAR CANCER THERAPEUTICS (2017)

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Article Biotechnology & Applied Microbiology

Clinical Proof of Concept for a Novel Hepatocyte-Targeting GaINAc-siRNA Conjugate

Tracy S. Zimmermann et al.

MOLECULAR THERAPY (2017)

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Review Biochemistry & Molecular Biology

Bifunctional antimicrobial conjugates and hybrid antimicrobials

P. Klahn et al.

NATURAL PRODUCT REPORTS (2017)

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Article Biochemistry & Molecular Biology

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates

Jayaprakash K. Nair et al.

NUCLEIC ACIDS RESEARCH (2017)

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Review Pharmacology & Pharmacy

Recent advances in hepatocellular carcinoma therapy

Rinku Dutta et al.

PHARMACOLOGY & THERAPEUTICS (2017)

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Review Chemistry, Multidisciplinary

Development of liver cell-targeted drug delivery systems: experimental approaches

Yan A. Ivanenkov et al.

RUSSIAN CHEMICAL REVIEWS (2017)

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Hepatitis C virus management: potential impact of nanotechnology

Mostafa H. Elberry et al.

VIROLOGY JOURNAL (2017)

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Molecular basis of human CD22 function and therapeutic targeting

June Ereno-Orbea et al.

NATURE COMMUNICATIONS (2017)

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Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions

Vasilios Kalas et al.

SCIENCE ADVANCES (2017)

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Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging

Stefanie Wagner et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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What contributes to an effective mannose recognition domain?

Christoph P. Sager et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2017)

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Structure-Activity Studies of N-Butyl-1-deoxynojirimycin (NB-DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2

Xingxian Gu et al.

CHEMMEDCHEM (2017)

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Review Chemistry, Multidisciplinary

Recent Advances in the Chemical Synthesis of C-Glycosides

You Yang et al.

CHEMICAL REVIEWS (2017)

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Article Biochemistry & Molecular Biology

Encapsulating an Immunosuppressant Enhances Tolerance Induction by Siglec-Engaging Tolerogenic Liposomes

Lijuan Pang et al.

CHEMBIOCHEM (2017)

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Article Biochemistry & Molecular Biology

Calcium-Independent Activation of an Allosteric Network in Langerin by Heparin Oligosaccharides

Jonas Hanske et al.

CHEMBIOCHEM (2017)

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Article Biochemistry & Molecular Biology

New Human CD22/Siglec-2 Ligands with a Triazole Glycoside

Horst Prescher et al.

CHEMBIOCHEM (2017)

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Article Chemistry, Multidisciplinary

Two birds, one stone: dual targeting of the cancer cell surface and subcellular mitochondria by the galectin-3-binding peptide G3-C12

Wei Sun et al.

ACTA PHARMACOLOGICA SINICA (2017)

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Article Biochemistry & Molecular Biology

The Pseudomonas aeruginosa lectin LecA triggers host cell signalling by glycosphingolipid-dependent phosphorylation of the adaptor protein CrkII

Shuangshuang Zheng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

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Article Chemistry, Multidisciplinary

Identification of Multiple Druggable Secondary Sites by Fragment Screening against DC-SIGN

Jonas Aretz et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Article Cell Biology

Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling

James F. Sampson et al.

IMMUNOLOGY AND CELL BIOLOGY (2016)

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The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus

Wy Ching Ng et al.

JOURNAL OF VIROLOGY (2016)

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E-selectin ligand complexes adopt an extended high-affinity conformation

Roland C. Preston et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2016)

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Review Immunology

Galectins and Immune Responses-Just How Do They Do Those Things They Do?

Sandra Thiemann et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 34 (2016)

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Article Biochemistry & Molecular Biology

Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation

Catherine Cott et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

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Article Chemistry, Multidisciplinary

Galactose-amidine derivatives as selective antagonists of galectin-9

Santanu Mandal et al.

CANADIAN JOURNAL OF CHEMISTRY (2016)

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Article Biochemistry & Molecular Biology

Nonhydrolyzable C-disaccharides, a new class of DC-SIGN ligands

Benedetta Bertolotti et al.

CARBOHYDRATE RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

Tamara Delaine et al.

CHEMBIOCHEM (2016)

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Article Biochemistry & Molecular Biology

The Antiadhesive Strategy in Crohn's Disease: Orally Active Mannosides to Decolonize Pathogenic Escherichia coli from the Gut

Dimitri Alvarez Dorta et al.

CHEMBIOCHEM (2016)

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Article Chemistry, Medicinal

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI

Cassie Jarvis et al.

CHEMMEDCHEM (2016)

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Review Chemistry, Medicinal

Galectin-1 inhibitors and their potential therapeutic applications: a patent review

Helen Blanchard et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2016)

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Article Chemistry, Medicinal

Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

Stefanie Wagner et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Article Chemistry, Medicinal

A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

Vishal K. Rajput et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Article Chemistry, Medicinal

Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections

Laurel Mydock-McGrane et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Article Chemistry, Medicinal

FimH Antagonists: Phosphate Prodrugs Improve Oral Bioavailability

Simon Kleeb et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Article Chemistry, Multidisciplinary

Intradomain Allosteric Network Modulates Calcium Affinity of the C-Type Lectin Receptor Langerin

Jonas Hanske et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

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Article Chemistry, Organic

Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa

Ines Joachim et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2016)

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Article Chemistry, Organic

Synthesis of 28a-homoselenolupanes and 28a-homoselenolupane saponins

Katarzyna Sidoryk et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2016)

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Article Chemistry, Organic

Second generation of thiazolylmannosides, FimH antagonists for E. coli-induced Crohn's disease

T. Chalopin et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2016)

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Article Chemistry, Organic

Lewis Acid Induced Anomerization of Se-Glycosides. Application to Synthesis of α-Se-GalCer

Anthony W. McDonagh et al.

ORGANIC LETTERS (2016)

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Article Chemistry, Multidisciplinary

Overcoming antibiotic resistance in Pseudomonas aeruginosa biofilms using glycopeptide dendrimers

Gaelle Michaud et al.

CHEMICAL SCIENCE (2016)

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Article Chemistry, Multidisciplinary

The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery

Roman Sommer et al.

CHEMICAL SCIENCE (2016)

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Article Biochemistry & Molecular Biology

Development of a competitive binding assay for the Burkholderia cenocepacia lectin BC2L-A and structure activity relationship of natural and synthetic inhibitors

Ghamdan Beshr et al.

MEDCHEMCOMM (2016)

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Article Multidisciplinary Sciences

Structural basis of myelin-associated glycoprotein adhesion and signalling

Matti F. Pronker et al.

NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

Wei-Sheng Chen et al.

NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

Catch-bond mechanism of the bacterial adhesin FimH

Maximilian M. Sauer et al.

NATURE COMMUNICATIONS (2016)

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Article Microbiology

Genomic Rearrangements and Functional Diversification of lecA and lecB Lectin-Coding Regions Impacting the Efficacy of Glycomimetics Directed against Pseudomonas aeruginosa

Amine M. Boukerb et al.

FRONTIERS IN MICROBIOLOGY (2016)

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Review Oncology

Turning-Off Signaling by Siglecs, Selectins, and Galectins: Chemical inhibition of Glycan-Dependent interactions in Cancer

Alejandro J. Cagnoni et al.

FRONTIERS IN ONCOLOGY (2016)

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Article Biochemistry & Molecular Biology

Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA

Ricardo Visini et al.

ACS CHEMICAL BIOLOGY (2015)

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Review Biochemistry & Molecular Biology

Galectin expression in cancer diagnosis and prognosis: A systematic review

Victor L. Thijssen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2015)

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Article Chemistry, Medicinal

Thio- and selenoglycosides as ligands for biomedically relevant lectins: Valency-activity correlations for benzene-based dithiogalactoside clusters and first assessment for (di)selenodigalactosides

Sabine Andre et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)

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Article Hematology

Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use

Marilyn J. Telen et al.

BLOOD (2015)

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Meeting Abstract Oncology

A small molecule glycomimetic antagonist of E-selectin and CXCR4 (GMI-1359) prevents pancreatic tumor metastasis and improves chemotherapy

Maria M. Steele et al.

CANCER RESEARCH (2015)

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Meeting Abstract Oncology

Dual E-selectin and CXCR4 inhibition reduces tumor growth and increases the sensitivity to docetaxel in experimental bone metastases of prostate cancer

Giovanni L. Gravina et al.

CANCER RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Synthesis of mannoheptose derivatives and their evaluation as inhibitors of the lectin LecB from the opportunistic pathogen Pseudomonas aeruginosa

Anna Hofmann et al.

CARBOHYDRATE RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Thioglycosides in Carbohydrate Research

Gaoyan Lian et al.

CARBOHYDRATE RESEARCH (2015)

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Review Cardiac & Cardiovascular Systems

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

Rodger P. McEver

CARDIOVASCULAR RESEARCH (2015)

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Article Chemistry, Multidisciplinary

Glycosyldiselenides as lectin ligands detectable by NMR in biofluids

Ignacio Perez-Victoria et al.

CHEMICAL COMMUNICATIONS (2015)

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Article Biochemistry & Molecular Biology

Recent insights into structures and functions of C-type lectins in the immune system

Kurt Drickamer et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2015)

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Review Pharmacology & Pharmacy

Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies

Renato A. Bauer

DRUG DISCOVERY TODAY (2015)

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Article Biochemistry & Molecular Biology

A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2

Sabine A. F. Jegouzo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Review Chemistry, Multidisciplinary

Asialoglycoprotein receptor mediated hepatocyte targeting - Strategies and applications

Anisha A. D'Souza et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Medicinal

FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile

Simon Kleeb et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

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Article Chemistry, Multidisciplinary

Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands As Revealed by a Combination of NMR Spectroscopy and Cross-Linking Mapping Experiments

Juan C. Munoz-Garcia et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Article Chemistry, Multidisciplinary

Genetically Encoded Fragment-Based Discovery of Glycopeptide Ligands for Carbohydrate-Binding Proteins

Simon Ng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Article Chemistry, Multidisciplinary

Carbohydrate-Aromatic Interactions in Proteins

Kieran L. Hudson et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Article Medicine, Research & Experimental

G3-C12 Peptide Reverses Galectin-3 from Foe to Friend for Active Targeting Cancer Treatment

Wei Sun et al.

MOLECULAR PHARMACEUTICS (2015)

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Article Multidisciplinary Sciences

Novel antibody-antibiotic conjugate eliminates intracellular S. aureus

Sophie M. Lehar et al.

NATURE (2015)

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Article Biochemistry & Molecular Biology

Pharmacological folding chaperones act as allosteric ligands of Frizzled4

Serena F. Generoso et al.

NATURE CHEMICAL BIOLOGY (2015)

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Review Microbiology

Urinary tract infections: epidemiology, mechanisms of infection and treatment options

Ana L. Flores-Mireles et al.

NATURE REVIEWS MICROBIOLOGY (2015)

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Review Food Science & Technology

Pectin in cancer therapy: A review

Wenbo Zhang et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2015)

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Review Pharmacology & Pharmacy

Therapeutic Targeting of Siglecs using Antioody- and Glycan-Based Approaches

Takashi Angata et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2015)

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Article Microbiology

Development of Heptylmannoside-Based Glycoconjugate Antiadhesive Compounds against Adherent-Invasive Escherichia coli Bacteria Associated with Crohn's Disease

Adeline Sivignon et al.

MBIO (2015)

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Article Chemistry, Multidisciplinary

Cinnamide Derivatives of D-Mannose as Inhibitors of the Bacterial Virulence Factor LecB from Pseudomonas aeruginosa

Roman Sommer et al.

CHEMISTRYOPEN (2015)

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Review Chemistry, Multidisciplinary

Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands

Samy Cecioni et al.

CHEMICAL REVIEWS (2015)

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Article Multidisciplinary Sciences

Contribution of the CR Domain to P-Selectin Lectin Domain Allostery by Regulating the Orientation of the EGF Domain

Shouqin Lu et al.

PLOS ONE (2015)

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Structural Basis Underlying the Binding Preference of Human Galectins-1,-3 and-7 for Galβ1-3/4GlcNAc

Tung-Ju Hsieh et al.

PLOS ONE (2015)

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Article Chemistry, Medicinal

A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hernagglutinin Protein

Kris M. White et al.

ACS INFECTIOUS DISEASES (2015)

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Article Biochemistry & Molecular Biology

Unique DC-SIGN Clustering Activity of a Small Glycomimetic: A Lesson for Ligand Design

Ieva Sutkeviciute et al.

ACS CHEMICAL BIOLOGY (2014)

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Article Chemistry, Multidisciplinary

A LecA Ligand Identified from a Galactoside-Conjugate Array Inhibits Host Cell Invasion by Pseudomonas aeruginosa

Alexandre Novoa et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Article Biochemistry & Molecular Biology

Expanded potential of seleno-carbohydrates as a molecular tool for X-ray structural determination of a carbohydrate-protein complex with single/multi-wavelength anomalous dispersion phasing

Tatsuya Suzuki et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2014)

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Article Oncology

Abstract 33: OTX008 pharmacokinetics (PK) during the first-in-man phase I study in patients with advanced solid tumors .

Keyvan Rezai et al.

CANCER RESEARCH (2014)

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Meeting Abstract Oncology

A small molecule glycomimetic antagonist of E-selectin (GMI-1271) prevents pancreatic tumor metastasis and offers a novel treatment for improved efficacy of chemotherapy

Maria M. Steele et al.

CANCER RESEARCH (2014)

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Article Chemistry, Medicinal

Kinetic Properties of Carbohydrate-Lectin Interactions: FimH Antagonists

Meike Scharenberg et al.

CHEMMEDCHEM (2014)

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Article Biochemistry & Molecular Biology

Convergent and divergent mechanisms of sugar recognition across kingdoms

Maureen E. Taylor et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2014)

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Article Oncology

OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis

Lucile Astorgues-Xerri et al.

EUROPEAN JOURNAL OF CANCER (2014)

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Article Chemistry, Medicinal

Monovalent mannose-based DC-SIGN antagonists: Targeting the hydrophobic groove of the receptor

Tihomir Tomasic et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)

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Article Chemistry, Organic

Synthesis of Unnatural Phosphonosugar Analogues

Benedicte Dayde et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2014)

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Review Chemistry, Medicinal

Galectin-3 inhibitors: a patent review (2008-present)

Helen Blanchard et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2014)

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Article Biochemistry & Molecular Biology

NMR evidence for oligosaccharide release from the dendritic-cell specific intercellular adhesion molecule 3-grabbing non-integrin-related (CLEC4M) carbohydrate recognition domain at low pH

Fay Probert et al.

FEBS JOURNAL (2014)

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Article Chemistry, Multidisciplinary

Galactose-installed photo-crosslinked pH-sensitive degradable micelles for active targeting chemotherapy of hepatocellular carcinoma in mice

Yan Zou et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Article Chemistry, Medicinal

Antiadhesive Properties of Glycoclusters against Pseudomonas aeruginosa Lung Infection

Amine M. Boukerb et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

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Article Chemistry, Multidisciplinary

Superselective Targeting Using Multivalent Polymers

Galina V. Dubacheva et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Article Chemistry, Multidisciplinary

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

Jayaprakash K. Nair et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Review Microbiology

The sweet spot: defining virus-sialic acid interactions

Jennifer E. Stencel-Baerenwald et al.

NATURE REVIEWS MICROBIOLOGY (2014)

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Article Biochemistry & Molecular Biology

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

Thazha P. Prakash et al.

NUCLEIC ACIDS RESEARCH (2014)

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Article Multidisciplinary Sciences

A Biophysical Study with Carbohydrate Derivatives Explains the Molecular Basis of Monosaccharide Selectivity of the Pseudomonas aeruginosa Lectin LecB

Roman Sommer et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

Methylated glycans as conserved targets of animal and fungal innate defense

Therese Wohlschlager et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Multidisciplinary Sciences

A lipid zipper triggers bacterial invasion

Thorsten Eierhoff et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Biochemistry & Molecular Biology

A Platform of C-type Lectin-like Receptor CLEC-2 for Binding O-Glycosylated Podoplanin and Nonglycosylated Rhodocytin

Masamichi Nagae et al.

STRUCTURE (2014)

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Article Biochemistry & Molecular Biology

Structural Basis for Selective Recognition of Endogenous and Microbial Polysaccharides by Macrophage Receptor SIGN-R1

Noella Silva-Martin et al.

STRUCTURE (2014)

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Article Chemistry, Multidisciplinary

Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas

Cory D. Rillahan et al.

CHEMICAL SCIENCE (2014)

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Article Immunology

Computational and experimental prediction of human C-type lectin receptor druggability

Jonas Aretz et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Review Immunology

Siglec-mediated regulation of immune cell function in disease

Matthew S. Macauley et al.

NATURE REVIEWS IMMUNOLOGY (2014)

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Review Immunology

The origins and functions of dendritic cells and macrophages in the skin

Bernard Malissen et al.

NATURE REVIEWS IMMUNOLOGY (2014)

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Article Biochemistry & Molecular Biology

CH-π T-Shape Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa Lectin LecA

Rameshwar U. Kadam et al.

ACS CHEMICAL BIOLOGY (2013)

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Article Biochemistry & Molecular Biology

Discovery of Two Classes of Potent Glycomimetic Inhibitors of Pseudomonas aeruginosa LecB with Distinct Binding Modes

Dirk Hauck et al.

ACS CHEMICAL BIOLOGY (2013)

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Article Biochemistry & Molecular Biology

On-Chip Synthesis and Screening of a Sialoside Library Yields a High Affinity Ligand for Siglec-7

Cory D. Rillahan et al.

ACS CHEMICAL BIOLOGY (2013)

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Article Chemistry, Multidisciplinary

C-4 Modified Sialosides Enhance Binding to Siglec-2 (CD22): Towards Potent Siglec Inhibitors for Immunoglycotherapy

Sorge Kelm et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

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Article Pharmacology & Pharmacy

Siderophore conjugates

Malcolm G. P. Page

ANTIMICROBIAL THERAPEUTICS REVIEWS: THE BACTERIAL CELL WALL AS AN ANTIMICROBIAL TARGET (2013)

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Article Biochemistry & Molecular Biology

Galactosylated Micelles for a Ribavirin Prodrug Targeting to Hepatocytes

Emanuela F. Craparo et al.

BIOMACROMOLECULES (2013)

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Article Oncology

Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib

Massimo Zucchetti et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2013)

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Article Biochemistry & Molecular Biology

An α-selective, visible light photocatalytic glycosylation of alcohols with selenoglycosides

Mark Spell et al.

CARBOHYDRATE RESEARCH (2013)

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Review Biochemistry & Molecular Biology

Allostery in Disease and in Drug Discovery

Ruth Nussinov et al.

CELL (2013)

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Review Chemistry, Multidisciplinary

Recent developments in design and synthesis of bicyclic azasugars, carbasugars and related molecules as glycosidase inhibitors

Rima Lahiri et al.

CHEMICAL SOCIETY REVIEWS (2013)

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Review Chemistry, Multidisciplinary

Multivalent glycoconjugates as anti-pathogenic agents

Anna Bernardi et al.

CHEMICAL SOCIETY REVIEWS (2013)

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Glycopeptide dendrimers as Pseudomonas aeruginosa biofilm inhibitors

Jean-Louis Reymond et al.

CHEMICAL SOCIETY REVIEWS (2013)

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Optimizing Divalent Inhibitors of Pseudomonas aeruginosa Lectin LecA by Using A Rigid Spacer

Francesca Pertici et al.

CHEMISTRY-A EUROPEAN JOURNAL (2013)

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Selective Targeting of Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin (DC-SIGN) with Mannose-Based Glycomimetics: Synthesis and Interaction Studies of Bis(benzylamide) Derivatives of a Pseudomannobioside

Norbert Varga et al.

CHEMISTRY-A EUROPEAN JOURNAL (2013)

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Inhibition of metastatic tumor formation in vivo by a bacteriophage display-derived galectin-3 targeting peptide

Jessica R. Newton-Northup et al.

CLINICAL & EXPERIMENTAL METASTASIS (2013)

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Binding of Pk-Trisaccharide Analogs of Globotriaosylceramide to Shiga Toxin Variants

Hailemichael O. Yosief et al.

INFECTION AND IMMUNITY (2013)

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Allosteric Coupling in the Bacterial Adhesive Protein FimH

Victoria B. Rodriguez et al.

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Recognition of Bisecting N-Acetylglucosamine STRUCTURAL BASIS FOR ASYMMETRIC INTERACTION WITH THE MOUSE LECTIN DENDRITIC CELL INHIBITORY RECEPTOR 2

Masamichi Nagae et al.

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Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis

Matthew S. Macauley et al.

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Design and evaluation of polyamidoamine dendrimer conjugate with PEG, α-cyclodextrin and lactose as a novel hepatocyte-selective gene carrier in vitro and in vivo

Yuya Hayashi et al.

JOURNAL OF DRUG TARGETING (2013)

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A FimH Inhibitor Prevents Acute Bladder Infection and Treats Chronic Cystitis Caused by Multidrug-Resistant Uropathogenic Escherichia coli ST131

Makrina Totsika et al.

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Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn's Disease Patients

Sarni Brument et al.

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Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1

Hilde van Hattum et al.

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Structure of a Glycomimetic Ligand in the Carbohydrate Recognition Domain of C-type Lectin DC-SIGN. Structural Requirements for Selectivity and Ligand Design

Michel Thepaut et al.

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Nanomolar E-Selectin Antagonists with Prolonged Half-Lives by a Fragment-Based Approach

Jonas Egger et al.

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Synthesis of a selective inhibitor of a fucose binding bacterial lectin from Burkholderia ambifaria

Barbara Richichi et al.

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Aromatic thioglycoside inhibitors against the virulence factor LecA from Pseudomonas aeruginosa

Jacques Rodrigue et al.

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VEGFR1 and VEGFR2 Involvement in Extracellular Galectin-1-and Galectin-3-Induced Angiogenesis

Nicky D'Haene et al.

PLOS ONE (2013)

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Therapy of Experimental NASH and Fibrosis with Galectin Inhibitors

Peter G. Traber et al.

PLOS ONE (2013)

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Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease

Peter G. Traber et al.

PLOS ONE (2013)

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Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation

Norihito Kawasaki et al.

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Inhaled pan-selectin antagonist Bimosiamose attenuates airway inflammation in COPD

Henrik Watz et al.

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Effect of PSI-697, a Novel P-Selectin Inhibitor, on Platelet-Monocyte Aggregate Formation in Humans

Alan G. Japp et al.

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Structure-Based Optimization of Angiostatic Agent 6DBF7, an Allosteric Antagonist of Galectin-1

Ruud P. M. Dings et al.

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Noncarbohydrate Glycomimetics and Glycoprotein Surrogates as DC-SIGN Antagonists and Agonists

Lynne R. Prost et al.

ACS CHEMICAL BIOLOGY (2012)

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Regulation of Transforming Growth Factor-β1-driven Lung Fibrosis by Galectin-3

Alison C. MacKinnon et al.

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Sialyl Lewisx: A Pre-Organized Water Oligomer?

Florian P. C. Binder et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

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Multivalency as a Chemical Organization and Action Principle

Carlo Fasting et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

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Galectin-1-Specific Inhibitors as a New Class of Compounds To Treat HIV-1 Infection

Christian St-Pierre et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

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The Tyrosine Gate as a Potential Entropic Lever in the Receptor-Binding Site of the Bacterial Adhesin FimH

Adinda Wellens et al.

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Treatment of prostate carcinoma with (Galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates

Yang Yang et al.

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Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA

Francesca Pertici et al.

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Pre-organization of the Core Structure of E-Selectin Antagonists

Daniel Schwizer et al.

CHEMISTRY-A EUROPEAN JOURNAL (2012)

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In vivo Evaluation of FimH Antagonists - A Novel Class of Antimicrobials for the Treatment of Urinary Tract Infection

Daniela Abgottspon et al.

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Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases

Krikor Bijian et al.

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NMR study of ligand release from asialoglycoprotein receptor under solution conditions in early endosomes

Takuo Onizuka et al.

FEBS JOURNAL (2012)

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Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide

Roberta Marchetti et al.

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Inhalation with Fucose and Galactose for Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients

Hans-Peter Hauber et al.

International Journal of Medical Sciences (2012)

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Fucose-binding Lectin from Opportunistic Pathogen Burkholderia ambifaria Binds to Both Plant and Human Oligosaccharidic Epitopes

Aymeric Audfray et al.

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Antiadhesion Therapy for Urinary Tract Infections-A Balanced PK/PD Profile Proved To Be Key for Success

Xiaohua Jiang et al.

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Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides

Zhenfu Han et al.

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Target Selectivity of FimH Antagonists

Meike Scharenberg et al.

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Antitumor Agent Calixarene 0118 Targets Human Galectin-1 as an Allosteric Inhibitor of Carbohydrate Binding

Ruud P. M. Dings et al.

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In Silico-Aided Design of a Glycan Ligand of Sialoadhesin for in Vivo Targeting of Macrophages

Corwin M. Nycholat et al.

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Glycomimetic Ligands for the Human Asialoglycoprotein Receptor

Sreeman K. Mamidyala et al.

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Antigen Delivery to Macrophages Using Liposomal Nanoparticles Targeting Sialoadhesin/CD169

Weihsu C. Chen et al.

PLOS ONE (2012)

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Advances and prospects of anginex as a promising anti-angiogenesis and anti-tumor agent

Ju Bo Wang et al.

PEPTIDES (2012)

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Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions

Takumi Kiwamoto et al.

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Quinoxalinone inhibitors of the lectin DC-SIGN

Shane L. Mangold et al.

CHEMICAL SCIENCE (2012)

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Identification of functions linking quorum sensing with biofilm formation in Burkholderia cenocepacia H111

Silja Inhuelsen et al.

MICROBIOLOGYOPEN (2012)

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A Glycopeptide Dendrimer Inhibitor of the Galactose-Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms

Rameshwar U. Kadam et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

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N-acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers

Scott H. Medina et al.

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Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists

Oliver Schwardt et al.

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High affinity sialoside ligands of myelin associated glycoprotein

Ying Zeng et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

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The conformation of tetrafluorinated methyl galactoside anomers: crystallographic and NMR studies

Bruno Linclau et al.

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Iridium-catalysed condensation of alcohols and amines as a method for aminosugar synthesis

Ian Cumpstey et al.

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Arene-Anion Based Arginine-Binding Motif on a Galactose Scaffold: Structure-Activity Relationships of Interactions with Arginine-Rich Galectins

Christopher T. Oberg et al.

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Combining Glycomimetic and Multivalent Strategies toward Designing Potent Bacterial Lectin Inhibitors

Yoann M. Chabre et al.

CHEMISTRY-A EUROPEAN JOURNAL (2011)

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Inhibition of Galectins with Small Molecules

Christopher T. Oberg et al.

CHIMIA (2011)

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Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4+ T cells but are incapable of cross-presentation

Michiel van der Vlist et al.

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Synthesis of α-N-Linked Glycopeptides

Cinzia Colombo et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2011)

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Editorial Material Ophthalmology

Focus on Molecules: Galectin-3

Pablo Argueeso et al.

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Cell Surface Signaling Molecules in the Control of Immune Responses: A Tide Model

Yuwen Zhu et al.

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Type 1 Fimbrial Adhesin FimH Elicits an Immune Response That Enhances Cell Adhesion of Escherichia coli

Veronika Tchesnokova et al.

INFECTION AND IMMUNITY (2011)

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The Anti-angiogenic Peptide Anginex Greatly Enhances Galectin-1 Binding Affinity for Glycoproteins

Emma Salomonsson et al.

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Host-Soluble Galectin-1 Promotes HIV-1 Replication through a Direct Interaction with Glycans of Viral gp120 and Host CD4

Christian St-Pierre et al.

JOURNAL OF VIROLOGY (2011)

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Second generation of fucose-based DC-SIGN ligands: affinity improvement and specificity versus Langerin

Manuel Andreini et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2011)

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Glycomimetic Building Blocks: A Divergent Synthesis of Epimers of Shikimic Acid

Joseph C. Grim et al.

ORGANIC LETTERS (2011)

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Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A

Juliana Idoyaga et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Comparative analysis reveals selective recognition of glycans by the dendritic cell receptors DC-SIGN and Langerin

Andrea Holla et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2011)

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Efficacy of the pan-selectin antagonist Bimosiamose on ozone-induced airway inflammation in healthy subjects - A double blind, randomized, placebo-controlled, cross-over clinical trial

Anne Kirsten et al.

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Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors

Corinne K. Cusumano et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

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Targeting Plasmodium liver stages: better late than never

Steffen Borrmann et al.

TRENDS IN MOLECULAR MEDICINE (2011)

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Design and Synthesis of Benzenesulfonamide Derivatives as Potent Anti-Influenza Hemagglutinin Inhibitors

Guozhi Tang et al.

ACS MEDICINAL CHEMISTRY LETTERS (2011)

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Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity

Ondrej Sulak et al.

PLOS PATHOGENS (2011)

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Pseudomonas aeruginosa genomic structure and diversity

Jens Klockgether et al.

FRONTIERS IN MICROBIOLOGY (2011)

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Advances in the Biology and Chemistry of Sialic Acids

Xi Chen et al.

ACS CHEMICAL BIOLOGY (2010)

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Galectins: regulators of acute and chronic inflammation

Fu-Tong Liu et al.

YEAR IN IMMUNOLOGY 2 (2010)

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Glycan Encapsulated Gold Nanoparticles Selectively Inhibit Shiga Toxins 1 and 2

Ashish A. Kulkarni et al.

BIOCONJUGATE CHEMISTRY (2010)

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1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

Bader A. Salameh et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2010)

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In vivo targeting of B-cell lymphoma with glycan ligands of CD22

Weihsu C. Chen et al.

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GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

Jungshan Chang et al.

BLOOD (2010)

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Monovalent and bivalent N-fucosyl amides as high affinity ligands for Pseudomonas aeruginosa PA-IIL lectin

Manuel Andreini et al.

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Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting

Isolde Le Trong et al.

CELL (2010)

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A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN

Kathleen C. A. Garber et al.

CHEMICAL COMMUNICATIONS (2010)

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Selectin inhibitors: a patent review

Patricia W. Bedard et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2010)

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Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin

Emilie Lameignere et al.

GLYCOBIOLOGY (2010)

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Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin

Nikolaus Romani et al.

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Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

Bao Hoa Duong et al.

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Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists

Zhenfu Han et al.

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FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation

Tobias Klein et al.

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New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

Jonathan B. Baell et al.

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C-type lectin Langerin is a β-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi

Marein A. W. P. de Jong et al.

MOLECULAR IMMUNOLOGY (2010)

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The biofilm matrix

Hans-Curt Flemming et al.

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Visualization of Allostery in P-Selectin Lectin Domain Using MD Simulations

Shouqin Lue et al.

PLOS ONE (2010)

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Selectins promote tumor metastasis

Heinz Laeubli et al.

SEMINARS IN CANCER BIOLOGY (2010)

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Inhibition of Influenza Virus Infection by Multivalent Sialic-Acid-Functionalized Gold Nanoparticles

Ilona Papp et al.

SMALL (2010)

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A TNF-like Trimeric Lectin Domain from Burkholdeda cenocepacia with Specificity for Fucosylated Human Histo-Blood Group Antigens

Ondrej Sulak et al.

STRUCTURE (2010)

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Innate signaling by the C-type lectin DC-SIGN dictates immune responses

Jeroen den Dunnen et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2009)

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Role of LecA and LecB Lectins in Pseudomonas aeruginosa-Induced Lung Injury and Effect of Carbohydrate Ligands

Chanez Chemani et al.

INFECTION AND IMMUNITY (2009)

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Knocking Down Galectin 1 in Human Hs683 Glioblastoma Cells Impairs Both Angiogenesis and Endoplasmic Reticulum Stress Responses

Marie Le Mercier et al.

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CD205 (DEC-205): A recognition receptor for apoptotic and necrotic self

Rachel E. Shrimpton et al.

MOLECULAR IMMUNOLOGY (2009)

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From carbohydrate leads to glycomimetic drugs

Beat Ernst et al.

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Structural biology of the chaperone-usher pathway of pilus biogenesis

Gabriel Waksman et al.

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Maximising multivalency effects in protein-carbohydrate interactions

Roland J. Pieters

ORGANIC & BIOMOLECULAR CHEMISTRY (2009)

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Transmission of allostery through the lectin domain in selectin-mediated cell adhesion

Travis T. Waldron et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease

Sander I. van Kasteren et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Antibody to Langerin/CD207 localizes large numbers of CD8α+ dendritic cells to the marginal zone of mouse spleen

Juliana Idoyaga et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis

Neil C. Henderson et al.

AMERICAN JOURNAL OF PATHOLOGY (2008)

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Structural basis for mannose recognition by a lectin from opportunistic bacteria Burkholderia cenocepacia

Emilie Lameignere et al.

BIOCHEMICAL JOURNAL (2008)

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Ovarian tumor growth regression using a combination of vascular targeting agents anginex or topomimetic 0118 and the chemotherapeutic irofulven

Ruud P. M. Dings et al.

CANCER LETTERS (2008)

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Fiber formation across the bacterial outer membrane by the chaperone/usher pathway

Han Remaut et al.

CELL (2008)

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Synthesis of novel DC-SIGN ligands with an α-fucosylamide anchor

Gabriele Timpano et al.

CHEMBIOCHEM (2008)

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Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB

Emma M. V. Johansson et al.

CHEMISTRY & BIOLOGY (2008)

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Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: Synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides

Ian Cumpstey et al.

CHEMISTRY-A EUROPEAN JOURNAL (2008)

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Hemicarbasucrose: Turning off the exoanomeric effect induces less flexibility

Blanca Lopez-Mendez et al.

CHEMISTRY-AN ASIAN JOURNAL (2008)

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Galectins: structure, function and therapeutic potential

Ri-Yao Yang et al.

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Functional specializations of human epidermal langerhans cells and CD14+ dermal dendritic cells

Eynav Klechevsky et al.

IMMUNITY (2008)

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Burkholderia cepacia complex bacteria:: opportunistic pathogens with important natural biology

E. Mahenthiralingam et al.

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CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes

Cristal Huysamen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Integrin-like allosteric properties of the catch bond-forming FimH adhesin of Escherichia coli

Veronika Tchesnokova et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site

Alem W. Kahsai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Arginine binding motifs:: Design and synthesis of galactose-derived arginine tweezers as galectin-3 inhibitors

Christopher T. Oberg et al.

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Discovery of dapagliflozin: A potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes

Wei Meng et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

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Structural implications of Siglec-5-mediated sialoglycan recognition

Marina A. Zhuravleva et al.

JOURNAL OF MOLECULAR BIOLOGY (2008)

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Structural Basis of the Preferential Binding for Globo-Series Glycosphingolipids Displayed by Pseudomonas aeruginosa Lectin I

Bertrand Blanchard et al.

JOURNAL OF MOLECULAR BIOLOGY (2008)

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Sialoside analogue arrays for rapid identification of high affinity siglec ligands

Ola Blixt et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

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The caxbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site

Lorenz Chatwell et al.

MOLECULAR IMMUNOLOGY (2008)

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Synthesis of 6H-indolo[2,3-b]quinoxaline-N-glycosides and their cytotoxic activity against human ceratinocytes (HaCaT)

Katrin Marie Driller et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2008)

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Article Multidisciplinary Sciences

Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH-Oligomannose-3 Complex

Adinda Wellens et al.

PLOS ONE (2008)

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Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands:: Differential pH dependence, internalization and virion binding

Thomas Gramberg et al.

VIROLOGY (2008)

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Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis

Patricia W. Bedard et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

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Article Multidisciplinary Sciences

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne et al.

NATURE (2007)

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Non-carbo hydrate inhibitors of the lectin DC-SIGN

M. Jack Borrok et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

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Article Chemistry, Medicinal

X-ray structures and thermodynamics of the interaction of PA-IIL from pseudomonas aeruginosa with disaccharide derivatives

Karine Marotte et al.

CHEMMEDCHEM (2007)

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Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili

Kelly J. Wright et al.

CELLULAR MICROBIOLOGY (2007)

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Article Biochemistry & Molecular Biology

Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters

Ian Cumpstey et al.

CHEMBIOCHEM (2007)

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Interdomain interaction in the FimH adhesin of Escherichia coli regulates the affinity to mannose

Pavel Aprikian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

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Article Immunology

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death

Marta A. Toscano et al.

NATURE IMMUNOLOGY (2007)

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Synthesis of 2-C-branched derivatives of D-mannose:: 2-C-aminomethyl-D-mannose binds to the human C-type lectin DC-SIGN with affinity greater than an order of magnitude compared to that of D-mannose

Daniel A. Mitchell et al.

TETRAHEDRON-ASYMMETRY (2007)

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Article Chemistry, Medicinal

1,2-mannobioside mimic:: Synthesis, DC-SIGN interaction by NMR and docking, and antiviral activity

Jose J. Reina et al.

CHEMMEDCHEM (2007)

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Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli

Danelle S. Eto et al.

PLOS PATHOGENS (2007)

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CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease

Nicolas Barnich et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Article Biochemistry & Molecular Biology

Structure of the fungal β-glucan-binding immune receptor dectin-1:: Implications for function

James Brown et al.

PROTEIN SCIENCE (2007)

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Review Chemistry, Multidisciplinary

Synthesis and conformational and biological aspects of carbasugars

Odon Arjona et al.

CHEMICAL REVIEWS (2007)

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Rational design of novel, potent small molecule pan-selectin antagonists

Remo Kranich et al.

JOURNAL OF MEDICINAL CHEMISTRY (2007)

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Langerin is a natural barrier to HIV-1 transmission by Langerhans cells

Lot de Witte et al.

NATURE MEDICINE (2007)

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Article Chemistry, Medicinal

2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697):: Identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists

Neelu Kaila et al.

JOURNAL OF MEDICINAL CHEMISTRY (2007)

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Article Immunology

Neutralizing activity of polyvalent Gb(3), Gb(2) and galacto-trehalose models against Shiga toxins

Paola Neri et al.

MICROBIOLOGY AND IMMUNOLOGY (2007)

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Review Biochemistry & Molecular Biology

Targeting virulence: a new paradigm for antimicrobial therapy

Anne E. Clatworthy et al.

NATURE CHEMICAL BIOLOGY (2007)

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Review Biochemistry & Molecular Biology

Mannose 6-phosphate receptor targeting and its applications in human diseases

M. Gary-Bobo et al.

CURRENT MEDICINAL CHEMISTRY (2007)

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Article Biochemistry & Molecular Biology

Siglec-7 undergoes a major conformational change when complexed with the α(2,8)-disialylganglioside GT1b

Helen Attrill et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Biochemistry & Molecular Biology

Anti-angiogenesis and anti-tumor activity of recombinant anginex

Ricardo J. M. G. E. Brandwijk et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

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Article Chemistry, Organic

Screening for galectin-3 inhibitors from synthetic lacto-N-biose libraries using microscale affinity chromatography coupled to mass spectrometry

Sebastien Fort et al.

JOURNAL OF ORGANIC CHEMISTRY (2006)

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Article Biochemistry & Molecular Biology

The affinity of the FimH fimbrial adhesin is receptor-driven and quasi-independent of Escherichia coli pathotypes

Julie Bouckaert et al.

MOLECULAR MICROBIOLOGY (2006)

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Article Biotechnology & Applied Microbiology

Opinion - Drug-target residence time and its implications for lead optimization

Robert A. Copeland et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

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High-affinity ligand probes of CD22 overcome the threshold set by cis ligands for binding, endocytosis, and killing of B cells

Brian E. Collins et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Biochemistry & Molecular Biology

Antagonists of the myelin-associated glycoprotein:: A new class of tetrasaccharide mimics

Daniel Schwizer et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2006)

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Article Oncology

Design of nonpeptidic topomimetics of antiangiogenic proteins with antitumor activities

Ruud P. M. Dings et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)

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Article Biochemistry & Molecular Biology

Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted β strand displacement mechanism

Han Remaut et al.

MOLECULAR CELL (2006)

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Article Microbiology

The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa

Stephen P. Diggle et al.

ENVIRONMENTAL MICROBIOLOGY (2006)

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Langerhans cells cross-present antigen derived from skin

Patrizia Stoitzner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Review Biochemistry & Molecular Biology

Carbohydrates as future anti-adhesion drugs for infectious diseases

N Sharon

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2006)

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Article Multidisciplinary Sciences

Galectin-3 regulates myofibroblast activation and hepatic fibrosis

NC Henderson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Pharmacology & Pharmacy

Delivery of different length poly(L-lysine)-conjugated ODN to HepG2 cells using N-stearyllactobionamide-modified liposomes and their enhanced cellular biological effects

SL Wang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)

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Article Chemistry, Organic

Evaluation of the carbohydrate recognition domain of the bacterial adhesin FimH: design, synthesis and binding properties of mannoside ligands

Oliver Sperling et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2006)

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Article Virology

DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets

Chawaree Chaipan et al.

JOURNAL OF VIROLOGY (2006)

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Article Pharmacology & Pharmacy

Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: A randomized, double-blind, placebo controlled clinical cross-over-trial

Kai M. Beeh et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2006)

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Article Biochemistry & Molecular Biology

Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44

Alem W. Kahsai et al.

CHEMISTRY & BIOLOGY (2006)

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Review Biochemistry & Molecular Biology

The C-type lectin-like domain superfamily

AN Zelensky et al.

FEBS JOURNAL (2005)

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Article Rheumatology

The coming of age of galectins as immunomodulatory agents: impact of these carbohydrate binding proteins in T cell physiology and chronic inflammatory disorders

JM Ilarregui et al.

ANNALS OF THE RHEUMATIC DISEASES (2005)

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Article Biochemistry & Molecular Biology

The C-type lectin fold as an evolutionary solution for massive sequence variation

SA McMahon et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)

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Article Oncology

A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells

D Chauhan et al.

CANCER RESEARCH (2005)

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Article Biochemistry & Molecular Biology

The fucose-binding lectin from Ralstonia solanacearum -: A new type of β-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan

N Kostlánová et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Article Biochemistry & Molecular Biology

Structural basis for the interaction between human milk oligosaccharides and the bacterial lectin PA-IIL of Pseudomonas aeruginosa

S Perret et al.

BIOCHEMICAL JOURNAL (2005)

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Article Biochemistry & Molecular Biology

Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking

S Han et al.

NATURE CHEMICAL BIOLOGY (2005)

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Article Microbiology

Pseudomonas aeruginosa lectin LecB is located in the outer membrane and is involved in biofilm formation

D Tielker et al.

MICROBIOLOGY-SGM (2005)

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Article Immunology

Galectin-1 acts as a soluble host factor that promotes HIV-1 infectivity through stabilization of virus attachment to host cells

M Ouellet et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Biochemistry & Molecular Biology

On the role of galectin-3 in cancer apoptosis

S Nakahara et al.

APOPTOSIS (2005)

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Article Chemistry, Multidisciplinary

Structural and thermodynamic studies on cation -: II: interactions in lectin-ligand complexes:: High-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction

P Sörme et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

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Article Biochemistry & Molecular Biology

High affinity fucose binding of Pseudomonas aeruginosa lectin PA-IIL:: 1.0 Å resolution crystal structure of the complex combined with thermodynamics and computational chemistry approaches

EP Mitchell et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2005)

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Article Oncology

Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion

J Zou et al.

CARCINOGENESIS (2005)

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Review Oncology

Galectins as modulators of tumour progression

FT Liu et al.

NATURE REVIEWS CANCER (2005)

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Article Cell Biology

The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo

AER Hicks et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2005)

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Article Biochemistry & Molecular Biology

Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin

J Bouckaert et al.

MOLECULAR MICROBIOLOGY (2005)

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Article Chemistry, Multidisciplinary

1D saturation transfer difference NMR experiments on living cells: The DC-SIGN/oligomannose interaction

S Mari et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

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Article Chemistry, Multidisciplinary

C-2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions

I Cumpstey et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

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Article Multidisciplinary Sciences

Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact

BE Collins et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Oncology

Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection: A potential mechanism of tumor-immune privilege

N Rubinstein et al.

CANCER CELL (2004)

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Article Medicine, Research & Experimental

Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

RE Hunger et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

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Article Hematology

Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies

JF DiJoseph et al.

BLOOD (2004)

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Review Immunology

Structures of the lectins from Pseudomonas aeruginosa:: insights into the molecular basis for host glycan recognition

A Imberty et al.

MICROBES AND INFECTION (2004)

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Article Biochemistry & Molecular Biology

Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan

KK Sarangapani et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Biochemistry & Molecular Biology

Shear-dependent 'stick-and-roll' adhesion of type 1 fimbriated Escherichia coli

WE Thomas et al.

MOLECULAR MICROBIOLOGY (2004)

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Article Pharmacology & Pharmacy

Cellular disposition of arabinogalactan in primary cultured rat hepatocytes

T Tanaka et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2004)

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Review Cell Biology

Glycosphingolipids as toxin receptors

DC Smith et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2004)

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Article Biochemistry & Molecular Biology

Structure of the plasminogen kringle 4 binding calcium-free form of the C-type lectin-like domain of tetranectin

S Nielbo et al.

BIOCHEMISTRY (2004)

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Reproduction of Langerin/CD207 traffic and Birbeck granule formation in a human cell line model

R McDermott et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2004)

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Searching for new allosteric sites in enzymes

JA Hardy et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2004)

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Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR

Y Guo et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)

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Article Microbiology

Conservation of deduced amino acid sequence of FimH among Escherichia coli of bovine, porcine and avian disease origin

FJ Vandemaele et al.

VETERINARY MICROBIOLOGY (2004)

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Article Biochemistry & Molecular Biology

Ligands of the asialoglycoprotein receptor for targeted gene delivery, part 1: Synthesis of and binding studies with biotinylated cluster glycosides containing N-acetylgalactosamine

U Westerlind et al.

GLYCOCONJUGATE JOURNAL (2004)

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The polar hydrophobicity of fluorinated compounds

JC Biffinger et al.

CHEMBIOCHEM (2004)

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Article Biochemistry & Molecular Biology

Structural basis of calcium and galactose recognition by the lectin PA-IL of Pseudomonas aeruginosa

G Cioci et al.

FEBS LETTERS (2003)

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Article Biochemistry & Molecular Biology

Design of a partial peptide mimetic of anginex with antiangiogenic and anticancer activity

KH Mayo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Review Immunology

DC-sign: Escape mechanism for pathogens

Y van Kooyk et al.

NATURE REVIEWS IMMUNOLOGY (2003)

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Article Biochemistry & Molecular Biology

Structural basis of carbohydrate recognition by the lectin LecB from Pseudomonas aeruginosa

R Loris et al.

JOURNAL OF MOLECULAR BIOLOGY (2003)

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Article Biochemistry & Molecular Biology

DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2

PY Lozach et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Multidisciplinary Sciences

Direct observation of catch bonds involving cell-adhesion molecules

BT Marshall et al.

NATURE (2003)

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Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin

NR Zaccai et al.

STRUCTURE (2003)

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Article Chemistry, Organic

Parallel synthesis of glycomimetic libraries: Targeting a C-type lectin

MC Schuster et al.

ORGANIC LETTERS (2003)

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Article Veterinary Sciences

Sequence analysis demonstrates the conservation of fimH and variability of fimA throughout avian Pathogenic Escherichia coli (APEC)

F Vandemaele et al.

VETERINARY RESEARCH (2003)

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Article Immunology

Assessment in mice of the therapeutic potential of tailored, multivalent Shiga toxin carbohydrate ligands

GL Mulvey et al.

JOURNAL OF INFECTIOUS DISEASES (2003)

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Article Immunology

The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells

A Cambi et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2003)

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Article Oncology

Upregulation of galectins-1 and-3 in human colon cancer and their role in regulating cell migration

A Hittelet et al.

INTERNATIONAL JOURNAL OF CANCER (2003)

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Mycobacteria target DC-SIGN to suppress dendritic cell function

TBH Geijtenbeek et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

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Review Biochemistry & Molecular Biology

Tumor galectinology: Insights into the complex network of a family of endogenous lectins

H Lahm et al.

GLYCOCONJUGATE JOURNAL (2003)

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Article Biochemistry & Molecular Biology

Synthesis of N-glycoside analogs via thionolactones

WD Wang et al.

JOURNAL OF CARBOHYDRATE CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients

E Mitchell et al.

NATURE STRUCTURAL BIOLOGY (2002)

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Article Biochemistry & Molecular Biology

Exploring the 3D molecular architecture of Escherichia coli type 1 pili

E Hahn et al.

JOURNAL OF MOLECULAR BIOLOGY (2002)

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Review Chemistry, Medicinal

Design and synthesis of sialyl Lewisx mimics as E- and P-selectin inhibitors

N Kaila et al.

MEDICINAL RESEARCH REVIEWS (2002)

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Article Pharmacology & Pharmacy

Fondaparinux: A new antithrombotic agent

JWM Cheng

CLINICAL THERAPEUTICS (2002)

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Article Biochemistry & Molecular Biology

Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes

M Colmenares et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Clinical Neurology

Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases

I Camby et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2002)

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Article Virology

C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans

CP Alvarez et al.

JOURNAL OF VIROLOGY (2002)

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Article Immunology

The ligand-binding domain of CD22 is needed for inhibition of the B cell receptor signal, as demonstrated by a novel human CD22-specific inhibitor compound

S Kelm et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

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Article Biochemistry & Molecular Biology

Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection

CS Hung et al.

MOLECULAR MICROBIOLOGY (2002)

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Review Pharmacology & Pharmacy

Glycosylphosphatidylinositol (GPI)-anchored proteins

H Ikezawa

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2002)

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Review Chemistry, Multidisciplinary

Chemical diversity in the sialic acids and related α-keto acids:: An evolutionary perspective

T Angata et al.

CHEMICAL REVIEWS (2002)

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Review Biotechnology & Applied Microbiology

Targeting glycosylation as a therapeutic approach

RA Dwek et al.

NATURE REVIEWS DRUG DISCOVERY (2002)

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Article Immunology

The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells

A Engering et al.

JOURNAL OF IMMUNOLOGY (2002)

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Article Cell Biology

Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where langerin accumulates

R Mc Dermott et al.

MOLECULAR BIOLOGY OF THE CELL (2002)

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Article Biochemistry & Molecular Biology

Galectin-3 and metastasis

Y Takenaka et al.

GLYCOCONJUGATE JOURNAL (2002)

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Article Biochemistry & Molecular Biology

Introduction to galectins

H Leffler et al.

GLYCOCONJUGATE JOURNAL (2002)

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Review Chemistry, Organic

Synthesis and biological properties of monothiosaccharides

I Robina et al.

CURRENT ORGANIC CHEMISTRY (2001)

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Review Pharmacology & Pharmacy

Cell-specific delivery of genes with glycosylated carriers

M Hashida et al.

ADVANCED DRUG DELIVERY REVIEWS (2001)

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Article Chemistry, Organic

Stereoselective synthesis of conformationally constrained cyclohexanediols: A set of molecular scaffolds for the synthesis of glycomimetics

A Bernardi et al.

JOURNAL OF ORGANIC CHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

The ligand-binding loops in the tunicate C-type lectin TC14 are rigid

SF Poget et al.

BIOCHEMISTRY (2001)

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Article Pediatrics

Successful treatment of Pseudomonas aeruginosa respiratory tract infection with a sugar solution - a case report on a lectin based therapeutic principle

P von Bismarck et al.

KLINISCHE PADIATRIE (2001)

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Article Toxicology

Preclinical evaluation of the cardiotoxicity of PK2: A novel HPMA copolymer-doxorubicin-galactosamine conjugate antitumour agent

JW Hopewell et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2001)

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Article Hematology

Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid cells

VHJ van der Velden et al.

BLOOD (2001)

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Article Biochemistry & Molecular Biology

Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor

LO Gerlach et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Chemistry, Multidisciplinary

Evidence for receptor-mediated hepatic uptake of pullulan in rats

Y Kaneo et al.

JOURNAL OF CONTROLLED RELEASE (2001)

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Article Biochemistry & Molecular Biology

Mechanism of pH-dependent N-acetylgalactosamine binding by a functional mimic of the hepatocyte asialoglycoprotein receptor

H Feinberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Biochemistry & Molecular Biology

Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLeX and PSGL-1

WS Somers et al.

CELL (2000)

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Article Biochemistry & Molecular Biology

Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor

M Meier et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)

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Article Pharmacology & Pharmacy

Drug-like properties and the causes of poor solubility and poor permeability

CA Lipinski

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2000)

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Article Biochemistry & Molecular Biology

Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses

TBH Geijtenbeek et al.

CELL (2000)

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Article Biochemistry & Molecular Biology

DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells

TBH Geijtenbeek et al.

CELL (2000)

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Article Multidisciplinary Sciences

Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands

PI Kitov et al.

NATURE (2000)

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Article Chemistry, Multidisciplinary

A computational study of cation-π interactions vs salt bridges in aqueous media:: Implications for protein engineering

JP Gallivan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)

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