Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 21, Issue 23, Pages 4766-4769Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3ob00695f
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An environmentally friendly and transition metal-free method for the annulation of alpha-bromocinnamaldehydes was developed, resulting in the synthesis of 3-formyl-imidazo[1,2-alpha]pyridines and pyrimidines with moderate to excellent yields. This method is characterized by the use of readily available starting materials, transition metal-free conditions, good functional group tolerance, and operational simplicity.
An environmentally friendly and transition metal-free method for the annulation of alpha-bromocinnamaldehydes was established. 3-Formyl-imidazo[1,2-alpha]pyridines and pyrimidines were obtained in moderate to excellent yields. This approach features easily available starting materials, transition metal-free conditions, good functional group tolerance and operational simplicity.
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