4.7 Review

T-2 toxin metabolism and its hepatotoxicity: New insights on the molecular mechanism and detoxification

Related references

Note: Only part of the references are listed.
Article Chemistry, Applied

T-2 and HT-2 toxins in harvested oat grains and their prevalence in whole grain flour during storage

Sigita Janaviciene et al.

Summary: Mycotoxin contamination of food is a global concern. This study aimed to optimize and validate a method for detecting T-2/HT-2 toxin concentrations in oats and observe the changes in toxin concentrations in oat flour during storage under different temperature and humidity conditions. The results showed that A type trichothecenes contamination was widespread in oats, with the highest contamination occurring under warm and wet weather conditions. Long-term storage had an impact on toxin production, with temperature and time being the most important factors.

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2022)

Article Biotechnology & Applied Microbiology

Levels of T-2 toxin and its metabolites, and the occurrence of Fusarium fungi in spring barley in the Czech Republic

Marek Pernica et al.

Summary: Mycotoxins have been extensively studied, but further multidisciplinary research is needed to better understand and clarify related issues. The use of HPLC-MS in Czech spring barley revealed the dominance of F. poae and F. tricinctum in the prevalence of T-2 toxin and other mycotoxins.

FOOD MICROBIOLOGY (2022)

Article Food Science & Technology

Impact of a Natural Fusarial Multi-Mycotoxin Challenge on Broiler Chickens and Mitigation Properties Provided by a Yeast Cell Wall Extract and a Postbiotic Yeast Cell Wall-Based Blend

Manoj B. Kudupoje et al.

Summary: The yeast cell wall extract (YCWE) and post-biotic yeast cell wall-based blend (PYCW) were found to alleviate the negative effects of multiple toxins on commercial broilers.

TOXINS (2022)

Article Food Science & Technology

Stressful Effects of T-2 Metabolites and Defense Capability of HepG2 Cells

Mercedes Taroncher et al.

Summary: The antioxidant defense system in HepG2 cells was evaluated against oxidative stress induced by T-2 toxin and its metabolites. The study found that the antioxidant enzymes system can alleviate the damage caused by T-2 and its metabolites in HepG2 cells.

TOXINS (2022)

Article Biochemistry & Molecular Biology

Degradation of mycotoxins in mixtures by combined proteinous nanobiocatalysts: In silico, in vitro and in vivo

Ilya Lyagin et al.

Summary: New combined proteinous nanobiocatalysts were developed to destruct mycotoxins in mixtures. The selected enzymes and special biopolymers effectively stabilized the enzymes and reduced the negative effects of mycotoxins on animals in vivo. This study suggests that these nanobiocatalysts and enzymatic treatment could be a promising approach for ensuring food and feed chemical safety.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Article Food Science & Technology

Deoxynivalenol and T-2 Toxin as Major Concerns in Durum Wheat from Italy

Miriam Haidukowski et al.

Summary: Fusarium Head Blight, caused by various Fusarium species, is a destructive disease of wheat. The occurrence and mycotoxin contamination of these species vary in different regions of Italy. Deoxynivalenol was mainly detected in Central and Northern Italy, while T-2 and HT-2 toxins were predominantly found in Southern Italy. Fusarium graminearum was mainly present in Northern Italy, whereas F. langsethiae was more prevalent in Southern Italy.

TOXINS (2022)

Article Food Science & Technology

Can Red Yeast (Sporidiobolus pararoseus) Be Used as a Novel Feed Additive for Mycotoxin Binders in Broiler Chickens?

Orranee Srinual et al.

Summary: The study evaluated the efficacy of red yeast (Sporidiobolus pararoseus; RY) as a mycotoxin binder in broiler chickens. Results showed that RY supplementation effectively alleviated the toxicity induced by aflatoxin B1 and ochratoxin A, indicating its potential as a novel feed additive in the broiler industry.

TOXINS (2022)

Article Pharmacology & Pharmacy

The combination of T-2 toxin and acrylamide synergistically induces hepatotoxicity and nephrotoxicity via the activation of oxidative stress and the mitochondrial pathway

Lirui Hou et al.

Summary: The combined exposure of T-2 toxin and ACR showed synergistic cytotoxicity in vitro and significantly increased liver and kidney toxicity in vivo, leading to enhanced oxidative stress generation. It emphasized the necessity to consider the combined toxicity during the safety assessment of these food-borne contaminants.

TOXICON (2021)

Article Veterinary Sciences

Protective effect of selenomethionine on T-2 toxin-induced liver injury in New Zealand rabbits

Yumei Liu et al.

Summary: The study demonstrated that low-dose SeMet effectively protected rabbit hepatocytes from T-2 toxin-induced liver injury by reducing oxidative stress, hepatocyte apoptosis, and modulating the expression of apoptosis-related proteins.

BMC VETERINARY RESEARCH (2021)

Article Biochemistry & Molecular Biology

Role of DNA methylation-related chromatin remodeling in aryl hydrocarbon receptor-dependent regulation of T-2 toxin highly inducible Cytochrome P450 1A4 gene

Jun Jiang et al.

Summary: The study found that T-2 toxin and its metabolites induce the expression of cytochrome P450 1A4 gene, involving the regulation of aryl hydrocarbon receptor and DNA methylation. T-2 toxin activates AhR, leading to transcriptional activation of the cytochrome P450 1A4 gene.

FASEB JOURNAL (2021)

Article Agriculture, Dairy & Animal Science

Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets

Insaf Riahi et al.

Summary: The contamination of animal feed with mycotoxins is a global concern, leading to adverse effects on productivity and animal health. The addition of detoxifying agents, such as MMDA, to contaminated diets can alleviate the negative impact of mycotoxins on broiler chickens.

ANIMALS (2021)

Review Physiology

Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress

Hasna Tirichen et al.

Summary: Mitochondrial reactive oxygen species (mtROS) and oxidative stress (OS) result in oxidative damage to cellular components such as lipids, DNA, and proteins, contributing to kidney damage and the progression of chronic kidney disease (CKD).

FRONTIERS IN PHYSIOLOGY (2021)

Article Biochemistry & Molecular Biology

Effects of Fusarium Mycotoxin Exposure on Lipid Peroxidation and Glutathione Redox System in the Liver of Laying Hens

Szabina Kulcsar et al.

Summary: Studies have shown that Fusarium mycotoxins induce oxidative stress and lipid peroxidation in animals. Different Fusarium mycotoxins had varying effects on the antioxidant defense and gene expression levels in laying hens, causing low-level oxidative stress at the dose applied.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

Activated FXR promotes xenobiotic metabolism of T-2 toxin and attenuates oxidative stress in broiler chicken liver

Depeng Dai et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

Review Food Science & Technology

Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans

Wim Schelstraete et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

Article Food Science & Technology

Cellular Effects of T-2 Toxin on Primary Hepatic Cell Culture Models of Chickens

Mate Mackei et al.

TOXINS (2020)

Article Multidisciplinary Sciences

Toxicopathological studies on the effects of T-2 mycotoxin and their interaction in juvenile goats

Shivasharanappa Nayakwadi et al.

PLOS ONE (2020)

Article Toxicology

Does low concentration mycotoxin exposure induce toxicity in HepG2 cells through oxidative stress?

Mercedes Taroncher et al.

TOXICOLOGY MECHANISMS AND METHODS (2020)

Article Environmental Sciences

Effects of maternal T-2 toxin exposure on the hepatic glycolipid metabolism in young mice

Ruifen Kang et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

Review Medicine, General & Internal

Bile Acids and FXR: Novel Targets for Liver Diseases

Mary Stofan et al.

FRONTIERS IN MEDICINE (2020)

Review Food Science & Technology

Presence of Mycotoxins in Milk Thistle (Silybum marianum) Food Supplements: A Review

Darina Pickova et al.

TOXINS (2020)

Article Food Science & Technology

Carry-over of some Fusarium mycotoxins in tissues and eggs of chickens fed experimentally mycotoxin-contaminated diets

Tangni K. Emmanuel et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

Article Food Science & Technology

DNA methylation is involved in pro-inflammatory cytokines expression in T-2 toxin-induced liver injury

Aimei Liu et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Article Food Science & Technology

Cytotoxic effects induced by patulin, deoxynivalenol and toxin T2 individually and in combination in hepatic cells (HepG2)

Celia Fernandez-Blanco et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

Article Agriculture, Multidisciplinary

Multi-mycotoxin exposure and risk assessments for Chinese consumption of nuts and dried fruits

Wang Yu-jiao et al.

JOURNAL OF INTEGRATIVE AGRICULTURE (2018)

Article Fisheries

Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.)

Iveta Matejova et al.

FISH & SHELLFISH IMMUNOLOGY (2017)

Article Food Science & Technology

Hepatotoxicity of fusariotoxins, alone and in combination, towards the HepaRG human hepatocyte cell line

Marie-Caroline Smith et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

Article Agriculture, Multidisciplinary

Mycotoxins in Plant-Based Dietary Supplements: Hidden Health Risk for Consumers

Zdenka Veprikova et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Effects of Different Selenium Levels on Gene Expression of a Subset of Selenoproteins and Antioxidative Capacity in Mice

Qin Zhang et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2013)

Review Pharmacology & Pharmacy

Contamination and adulteration of herbal medicinal products (HMPs): an overview of systematic reviews

Paul Posadzki et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2013)

Review Multidisciplinary Sciences

Mitochondrial Fission, Fusion, and Stress

Richard J. Youle et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

Effects of Dietary Selenium Source, Storage Time, and Temperature on the Quality of Quail Eggs

Mikail Baylan et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2011)

Review Biochemistry & Molecular Biology

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

Roy L. Silverstein et al.

SCIENCE SIGNALING (2009)

Review Public, Environmental & Occupational Health

T-2 toxin: Incidence and toxicity in poultry

Marijana Sokolovic et al.

ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY (2008)

Review Biochemistry & Molecular Biology

Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion

Huawei Zeng et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2008)

Review Biochemistry & Molecular Biology

From selenium to selenoproteins: Synthesis, identity, and their role in human health

Laura Vanda Papp et al.

ANTIOXIDANTS & REDOX SIGNALING (2007)

Review Agriculture, Dairy & Animal Science

Toxicological evaluation of trichothecenes in animal feed

GS Eriksen et al.

ANIMAL FEED SCIENCE AND TECHNOLOGY (2004)