Recent advances in oxidative phenol coupling for the total synthesis of natural products

Covering: 2008 to 2023 This review will describe oxidative phenol coupling as applied in the total synthesis of natural products. This review covers catalytic and electrochemical methods with a brief comparison to stoichiometric and enzymatic systems assessing their practicality, atom economy, and other measures. Natural products forged by C-C and C-O oxidative phenol couplings as well as from alkenyl phenol couplings will be addressed. Additionally, exploration into catalytic oxidative coupling of phenols and other related species (carbazoles, indoles, aryl ethers, etc.) will be surveyed. Future directions of this particular area of research will also be assessed.

Automated summary

Covering the period from 2008 to 2023, this review examines the use of oxidative phenol coupling in the total synthesis of natural products. The review explores catalytic and electrochemical methods, comparing them to stoichiometric and enzymatic systems in terms of practicality, atom economy, and other factors. It also discusses the synthesis of natural products through C-C and C-O oxidative phenol couplings, as well as alkenyl phenol couplings. Additionally, the review surveys the catalytic oxidative coupling of phenols and other related species, such as carbazoles, indoles, and aryl ethers. Future research directions in this field are also assessed.