Journal
CHINESE JOURNAL OF ORGANIC CHEMISTRY
Volume 43, Issue 5, Pages 1691-1705Publisher
SCIENCE PRESS
DOI: 10.6023/cjoc202302022
Keywords
meta selectivity; para selectivity; iridium catalysis; C-H borylation; directing groups
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Organoboron compounds serve as important building blocks to generate molecular diversity, and strategies enabling the conversion of readily available hydrocarbons into these compounds through C-H borylation are highly appealing. While significant progress has been made in ortho-selective C-H borylation, achieving meta-/para-selectivity remains challenging. This review provides a comprehensive overview of iridium-catalyzed meta-/para-selective aromatic C-H borylation, categorized into directed and non-directed approaches.
Organoboron compounds are important building blocks to create molecular diversity. Strategies that can transform the readily available hydrocarbons into these compounds by C-H borylation are highly attractive. In this context, significant progress has been made towards iridium-catalyzed C-H borylation. Because substituted arenes typically contain ortho-, meta- and para-C-H bonds, regiocontrol has been a long-standing challenge within this type of chemistry. During the past decade, significant progress has been made in the ortho-selective C-H borylation, while the meta-/para-selectivity is still challenging. This review aims to provide a comprehensive overview of this topic on meta-/para-selective aromatic C-H borylation by iridium catalysis. This topic is categorized into directed and non-directed C-H borylation.
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