Unknown Circovirus in Immunosuppressed Patient with Hepatitis, France, 2022

Article Microbiology

Viral genomic, metagenomic and human transcriptomic characterization and prediction of the clinical forms of COVID-19

Christophe Rodriguez et al.

Summary: This study utilized shotgun metagenomics and in-depth bioanalysis to investigate the role of viral genomics, microorganism metagenomics, and host transcriptomics in the severity of COVID-19. Severe COVID-19 pneumonia was associated with overexpression of cytokine transcripts activating the CXCR2 pathway, while patients with benign disease presented with a specific T cell profile and a lower mortality rate. Excess neutrophil infiltration leading to enhanced inflammatory response and prolonged tissue damage was identified as a key factor in the most severe cases of COVID-19. The study suggests that CXCR2 antagonists, especially IL-8 antagonists, could be promising candidates for treating severe COVID-19 patients.

PLOS PATHOGENS (2021)

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Article Clinical Neurology

Fatal encephalitis caused by Newcastle disease virus in a child

Sarah Winter et al.

ACTA NEUROPATHOLOGICA (2021)

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Article Infectious Diseases

Identification of novel circovirus and anelloviruses from wolverines using a non-invasive faecal sampling approach

Rohan Antonio Bandoo et al.

Summary: Viruses in the families Circoviridae and Anelloviridae, with circular single-stranded DNA genomes, have been identified in various animal species. Novel circovirus and anelloviruses were discovered in wolverines through non-invasive sampling, shedding light on the little-known viruses associated with these forest carnivores. The newly identified viruses present new avenues for further research.

INFECTION GENETICS AND EVOLUTION (2021)

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Article Infectious Diseases

Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition

Viviane Saporiti et al.

Summary: PCV-3 was discovered in 2015 and has been detected worldwide in pigs with various outcomes. While many studies suggest PCV-3 as a potential pathogen, strong evidence of its causality is still lacking, requiring further research to establish clear connections.

TRANSBOUNDARY AND EMERGING DISEASES (2021)

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Article Virology

Circovirus in Blood of a Febrile Horse with Hepatitis

Alvin Hui et al.

Summary: Through viral metagenomics, a new species of Circovirus, equine circovirus 1 (EqCV1), was identified in a pregnant mare with fever and hepatitis. EqCV1 showed similarities to pig circoviruses and elk circovirus, indicating its evolutionary relationship. Further studies are needed to determine the disease-causing potential of EqCV1 and its prevalence in different equine populations.

VIRUSES-BASEL (2021)

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Article Health Care Sciences & Services

Pandemics- One Health preparedness for the next

Frank M. Aarestrup et al.

Summary: The article emphasizes the importance of early warning surveillance at the human, animal, environmental interface, particularly in early detection before the outbreak of emerging diseases. It highlights the potential of global genomic surveillance investments to achieve new pathogen monitoring and integrated prevention and control.

LANCET REGIONAL HEALTH-EUROPE (2021)

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Article Immunology