A Clinical Tool to Predict the Microvascular Invasion Risk in Patients with Hepatocellular Carcinoma

Article Gastroenterology & Hepatology

Preoperative prediction model of microvascular invasion in patients with hepatocellular carcinoma

Jianfeng Zhang et al.

Summary: This study aimed to construct a preoperative prediction model for microvascular invasion in hepatocellular carcinoma (HCC), providing clinicians with a reference for treatment options.

HPB (2023)

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Review Oncology

Immunotherapies for hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, specifically hepatocellular carcinoma (HCC), is the second leading cause of cancer-related death globally. Traditional treatments involve specific drugs, but the emergence of immune checkpoint inhibitors has revolutionized the management of HCC.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Review Medicine, General & Internal

Hepatocellular carcinoma

Arndt Vogel et al.

Summary: Hepatocellular carcinoma is a common cancer worldwide, with non-alcoholic fatty liver disease becoming a dominant cause. Treatment options are varied, including surgery, radiation, and medication. With the approval of new drugs and the development of immunotherapy, the outlook for hepatocellular carcinoma patients has improved, but the optimal sequencing of drugs and predictive biomarkers still need further research.

LANCET (2022)

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Article Oncology

A preoperative model for predicting microvascular invasion and assisting in prognostic stratification in liver transplantation for HCC regarding empirical criteria

Wenhui Zhang et al.

Summary: The study assessed a predictive model for microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients undergoing liver transplantation, identifying four preoperative risk factors associated with MVI. The predictive nomogram based on these factors demonstrated good performance in predicting MVI, with the ability to differentiate clinical outcomes within and beyond the Milan criteria.

TRANSLATIONAL ONCOLOGY (2021)

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Article Oncology

A Nomogram for Preoperative Estimation of Microvascular Invasion Risk in Hepatocellular Carcinoma: Single-Center Analyses With Internal Validation

Jiarui Yang et al.

Summary: A nomogram was established to predict the risk of microvascular invasion in hepatocellular carcinoma (HCC) preoperatively, which showed good discrimination, calibration, and effectiveness in internal validation. The predictive model demonstrated specificity of 80.7% and sensitivity of 58.7% at a cut-off value of 0.312, providing valuable guidance for treatment planning.

FRONTIERS IN ONCOLOGY (2021)

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Review Immunology

The contact system in liver injury

Chandini Rangaswamy et al.

Summary: Coagulation is controlled by a delicate balance of prothrombotic and antithrombotic mechanisms, with the liver playing a pivotal role in this process. Impaired liver function can lead to both hypercoagulability and bleeding disorders.

SEMINARS IN IMMUNOPATHOLOGY (2021)

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Article Multidisciplinary Sciences

Preoperative nomogram for microvascular invasion prediction based on clinical database in hepatocellular carcinoma

Shuqi Mao et al.

Summary: Microvascular invasion (MVI) is a critical factor for early HCC recurrence and prognosis. Through clinical database analysis, factors such as large tumor diameter, high AFP levels, and elevated total bilirubin levels were found to be associated with MVI. The developed nomogram model can predict the presence of MVI in HCC patients preoperatively.

SCIENTIFIC REPORTS (2021)

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Review Oncology