Journal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume 64, Issue 3, Pages -Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.64.3.29
Keywords
aqueous angiography; trabecular meshwork; aqueous humor outflow
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This study investigates the differences in outflow facility between high-flow and low-flow segments of the conventional outflow pathway in porcine eyes. It finds that there is an uneven distribution of local outflow facility across different parts of the trabecular meshwork.
PURPOSE. To investigate differences in outflow facility between angiographically deter-mined high-and low-flow segments of the conventional outflow pathway in porcine eyes. METHODS. Porcine anterior segments (n = 14) were mounted in a perfusion chamber and perfused using Dulbecco's phosphate buffered solution with glucose. Fluorescein angiography was performed to determine high-and low-flow regions of the conventional outflow pathways. The trabecular meshwork (TM) was occluded using cyanoacrylate glue, except for residual 5-mm TM areas that were either high or low flow at baseline, designating these eyes as residual high-flow or residual low-flow eyes. Subsequently, outflow was quantitatively reassessed and compared between residual high-flow and residual low-flow eyes followed by indocyanine green angiography. RESULTS. Fluorescein aqueous angiography demonstrated high-flow and low-flow regions. Baseline outflow facilities were 0.320 +/- 0.08 and 0.328 +/- 0.10 !IL/min/mmHg (P = 0.676) in residual high-flow and residual low-flow eyes before TM occlusion, respec-tively. After partial trabecular meshwork occlusion, outflow facility decreased to 0.209 +/- 0.07 !IL/min/mmHg (-32.66% +/- 19.53%) and 0.114 +/- 0.08 !IL/min/mmHg (-66.57% +/- 23.08%) in residual high-and low-flow eyes (P = 0.035), respectively. There was a significant difference in the resulting IOP increase (P = 0.034). CONCLUSIONS. Angiographically determined high-and low-flow regions in the conven-tional outflow pathways differ in their segmental outflow facility; thus, there is an uneven distribution of local outflow facility across different parts of the TM.
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