Soluble urokinase plasminogen activator receptor is associated with cardiovascular calcification in peritoneal dialysis patients

Article Urology & Nephrology

Cardiac valve calcification as a predictor of cardiovascular outcomes in peritoneal dialysis patients: an inverse probability of treatment weighting analysis

Jichao Guan et al.

Summary: This study retrospectively analyzed 458 PD patients and found that CVC is prevalent in these patients and is associated with CVE and cardiovascular mortality.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2023)

Add to Collection

Article Urology & Nephrology

Coronary artery calcification progression and long-term cardiovascular outcomes in renal transplant recipients: an analysis by the joint model

Nurhan Seyahi et al.

Summary: The study found that coronary artery calcification and its progression in renal transplant recipients can reliably predict the risk of death and cardiovascular events.

CLINICAL KIDNEY JOURNAL (2022)

Add to Collection

Article Urology & Nephrology

Use of the systemic inflammation response index (SIRI) as a novel prognostic marker for patients on peritoneal dialysis

Jiaqi Li et al.

Summary: This study assessed the predictive value of the systemic inflammatory response index (SIRI) on mortality outcomes in peritoneal dialysis (PD) patients. The results showed that a higher SIRI level was significantly associated with increased all-cause mortality and cardiovascular mortality in PD patients.

RENAL FAILURE (2022)

Add to Collection

Article Medicine, Research & Experimental

Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis

George Hindy et al.

Summary: This study investigated the pathogenic involvement of soluble urokinase plasminogen activator receptor (suPAR) in atherosclerosis. The researchers found that suPAR levels were predictive of coronary artery calcification and cardiovascular events. Through genetic analysis and experimental models, they identified a variant in the PLAUR gene that led to higher suPAR levels and confirmed a causal association between suPAR levels and atherosclerotic phenotypes. The study also found that suPAR affected monocyte function, leading to increased inflammation and chemotaxis.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Add to Collection

Article Medicine, Research & Experimental

Clinical, genetic, and experimental increase in soluble urokinase plasminogen activator receptor levels promotes atherosclerosis

George Hindy et al.

Summary: The study using epidemiologic, genetic, and experimental approaches found that suPAR is a pathogenic factor for atherosclerosis, with its levels strongly associated with cardiovascular outcomes and predictive of coronary artery calcification. The missense variant rs4760 in the PLAUR gene leads to higher suPAR levels, and Mendelian randomization analysis confirms a causal relationship between genetically predicted suPAR levels and atherosclerotic phenotypes. In experimental models, increased suPAR levels modulate monocyte function to promote atherosclerosis.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Soluble Urokinase-Type Plasminogen Activator Receptor, Changes of 24-Hour Blood Pressure, and Progression of Chronic Kidney Disease

Jong Hyun Jhee et al.

Summary: The study found that elevated serum suPAR levels in patients with chronic kidney disease are associated with abnormal 24-hour blood pressure patterns and an increased risk of kidney disease progression. This association is particularly prominent in reverse dippers, where higher suPAR levels are significantly correlated with an increased risk of CKD progression.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems