Journal
JOURNAL OF MEDICAL ULTRASOUND
Volume 31, Issue 1, Pages 63-65Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/jmu.jmu_83_21
Keywords
BRCA; breast cancer on fibroadenoma; triple-negative breast cancer
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We present the case of a 35-year-old woman with a palpable lump on her left breast. Ultrasound-guided core needle biopsy revealed high-grade ductal carcinoma in situ on fibroadenoma. The patient was diagnosed with triple-negative breast cancer arising on fibroadenoma and a BRCA1 gene mutation was detected.
We describe the case of a 35-year-old woman who comes to our institute with a palpable lump on her left breast. Clinically the mass was mobile, nontender and with no nipple discharge. Sonography revealed a circumscribed, oval-shaped, and hypoechoic mass, suggestive of a benign lesion. We performed an ultrasound-guided core needle biopsy that demonstrated multiple foci of high-grade (G3) ductal carcinoma in situ arising on fibroadenoma (FA). Subsequently, the patient had surgical excision of the mass with a final diagnosis of triple-negative breast cancer arising on FA. After diagnosis, the patient performs a genetic test that detects the BRCA 1 gene mutation. A review of the literature demonstrated only two cases of triple-negative breast cancer on FA. In this report, we describe another such case.
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