Zn-ProPhenol catalyzed asymmetric inverse-electron-demand Diels-Alder reaction

The first Zn-ProPhenol catalyzed asymmetric inverse-electron-demand Diels-Alder reaction has been accomplished. This protocol was carried out by a dual-activation mode under mild conditions, allowing the preparation of various biologically important dihydropyrans in good yields with excellent stereoselectivities.

Automated summary

The first Zn-ProPhenol catalyzed asymmetric inverse-electron-demand Diels-Alder reaction has been successfully achieved. This method employs a dual-activation mode under mild conditions, enabling the synthesis of diverse biologically important dihydropyrans in high yields and excellent stereoselectivities.