Acute Myeloid Leukemia with NPM1 Mutation and Disseminated Leukemia Cutis: Achievement of Molecular Complete Remission by Venetoclax/Azacitidine Combination in a Very Old Patient

We describe a case of acute myeloid leukemia with NPM1 mutation and disseminated leukemia cutis in a very old patient, who achieved a long-lasting response to the azacitidine/venetoclax combination with molecular complete remission, given the potential value of this rarely observed clinical outcome.

Automated summary

We present a rare case of a very old patient with acute myeloid leukemia and disseminated leukemia cutis, containing an NPM1 mutation. The patient achieved a long-lasting molecular complete remission with the azacitidine/venetoclax combination therapy, highlighting its potential value in such cases.