4.4 Review

Sex Hormones, Neurosteroids, and Glutamatergic Neurotransmission: A Review of the Literature

Related references

Note: Only part of the references are listed.
Article Psychology, Clinical

Estradiol, Stress Reactivity, and Daily Affective Experiences in Trauma-Exposed Women

Jenna K. Rieder et al.

Summary: Lower estradiol levels are associated with more severe PTSD symptoms in trauma-exposed women, with greater sympathetic and lower hypothalamic-pituitary-adrenal axis reactivity in the low-estradiol menstrual cycle phase. This suggests that menstrual cycle phase may influence PTSD diagnosis and symptom severity in women, highlighting the importance of considering hormonal fluctuations in clinical assessments.

PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY (2022)

Article Multidisciplinary Sciences

Effect of monosodium glutamate on serum sex hormones and uterine histology in female rats along with its molecular docking and in-silico toxicity

Mahfoudh A. M. Abdulghani et al.

Summary: The study investigated the toxic effects of MSG on the uterus in rats, revealing alterations in hormone levels and changes in uterine structure. Therefore, caution should be exercised when using MSG, especially for females at risk of hormonal abnormalities.

HELIYON (2022)

Article Neurosciences

Impact of hormonal contraceptives on sex differences in fear conditioning and fear extinction in PTSD

Morgan E. Bartholomew et al.

Summary: Sex differences in fear conditioning and extinction, as well as the effects of hormones, may contribute to the development of PTSD. Hormonal contraceptives may enhance fear conditioning and extinction. Understanding the impact of sex and hormones on fear processes can provide insights into the pathophysiology of PTSD and potentially lead to sex-specific advancements in treatment.

LEARNING & MEMORY (2022)

Review Biochemistry & Molecular Biology

From Menopause to Neurodegeneration-Molecular Basis and Potential Therapy

Yu-Jung Cheng et al.

Summary: The impacts of menopause on neurodegenerative diseases, especially the changes in steroid hormones, have been described in cell, animal, and human models. The therapeutic effects of hormone replacement therapy on postmenopausal women with neurodegenerative diseases remain controversial due to the complex response of signaling pathways to aging and hormone treatments. Estrogen, progesterone, and IGF-1 play important roles in neuroprotection and their decreased levels during menopause are associated with disease progression, particularly Alzheimer's disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD

Felipe Borges Almeida et al.

Summary: This article discusses the role of the HPA axis under stressful conditions and the importance of allopregnanolone in promoting negative feedback mechanisms to restore homeostasis. Chronic, repeated exposure to stress may lead to dysfunction, contributing to the pathogenesis of major depressive disorder and post-traumatic stress disorder (PTSD).

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway

Ibrahim Khan et al.

Summary: The study demonstrated that glutamate-induced oxidative stress and neuroinflammation in rat brain could be alleviated by E2 through upregulating antioxidant pathways and deactivating stress kinases. Additionally, E2 also protected against synaptic loss and apoptotic neurodegeneration caused by glutamate exposure. Thus, E2 shows potential as a neuroprotective and neurotherapeutic agent in various neurodegenerative diseases.

ANTIOXIDANTS (2021)

Review Neurosciences

Oestradiol as a neuromodulator of learning and memory

Lisa R. Taxier et al.

NATURE REVIEWS NEUROSCIENCE (2020)

Article Neurosciences

Estradiol Modulates Neural and Behavioral Arousal in Women With Posttraumatic Stress Disorder During a Fear Learning and Extinction Task

Anneliis Sartin-Tarm et al.

BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING (2020)

Review Pharmacology & Pharmacy

The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder

Chadi G. Abdallah et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)

Article Critical Care Medicine

Testosterone Administration after Traumatic Brain Injury Reduces Mitochondrial Dysfunction and Neurodegeneration

Randhall B. Carteri et al.

JOURNAL OF NEUROTRAUMA (2019)

Article Psychiatry

Estradiol modulation of the renin-angiotensin system and the regulation of fear extinction

Jenna N. Parrish et al.

TRANSLATIONAL PSYCHIATRY (2019)

Article Anatomy & Morphology

Role of pyridoxine in GABA synthesis and degradation in the hippocampus

Hyo Young Jung et al.

TISSUE & CELL (2019)

Article Pharmacology & Pharmacy

Evaluating the role of astrocytes on β-estradiol effect on seizures of Pilocarpine epileptic model

Masoumeh Sarfi et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Review Neurosciences

Neuroactive steroids and PTSD treatment

Ann M. Rasmusson et al.

NEUROSCIENCE LETTERS (2017)

Review Neurosciences

Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies

Lynnette A. Averill et al.

NEUROSCIENCE LETTERS (2017)

Article Neurosciences

Glutamatergic system abnormalities in posttraumatic stress disorder

Daisuke Nishi et al.

PSYCHOPHARMACOLOGY (2015)

Review Clinical Neurology

Estrogen receptors' neuroprotective effect against glutamate-induced neurotoxicity

Yu-Long Lan et al.

NEUROLOGICAL SCIENCES (2014)

Article Endocrinology & Metabolism

Inhibition of Hippocampal Aromatization Impairs Spatial Memory Performance in a Male Songbird

David J. Bailey et al.

ENDOCRINOLOGY (2013)

Article Biochemistry & Molecular Biology

Allopregnanolone Potentiates the Glutamate-Mediated Seizures Induced by 4-Aminopyridine in Rat Hippocampus in vivo

Patricia Salazar et al.

NEUROCHEMICAL RESEARCH (2012)

Article Cell Biology

The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency

Jenq-Lin Yang et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2011)

Article Endocrinology & Metabolism

Allopregnanolone induces LHRH and glutamate release through NMDA receptor modulation

Fernando A. Giuliani et al.

ENDOCRINE (2011)

Article Neurosciences

Estradiol Rapidly Regulates Membrane Estrogen Receptor α Levels in Hypothalamic Neurons

Reymundo Dominguez et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Pharmacology & Pharmacy

The Testosterone-Derived Neurosteroid Androstanediol Is a Positive Allosteric Modulator of GABAA Receptors

Doodipala Samba Reddy et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)

Review Psychiatry

Cortisol and post-traumatic stress disorder in adults - Systematic review and meta-analysis

Marie-Louise Meewisse et al.

BRITISH JOURNAL OF PSYCHIATRY (2007)

Article Biochemistry & Molecular Biology

Brain aromatase: Roles in reproduction and neuroprotection

Charles F. Roselli

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Testosterone amplifies excitotoxic damage of cultured oligodendrocytes

A Caruso et al.

JOURNAL OF NEUROCHEMISTRY (2004)