Evaluation of serum levels of interleukins 6, 8, 17 and 22 in acne vulgaris: A cross-sectional study

Background: Acne vulgaris (AV) is a chronic, multifactorial, inflammatory skin disease, and it is now becoming increasingly clear that the inflammatory pathway is involved at a very early in the pathogenesis of acne. The Th17 cells, the activators of this cell line and its downstream effector cytokines, are all likely to have a critical role in inducing and maintaining the disease. Aim: To analyse the role of interleukins (ILs) 6, 8, 17 and 22 in the pathogenesis of acne. Materials and Methods: Sixty patients of AV and thirty age- and sex-matched controls were included in our study. Serum levels of interleukins 6, 8, 17 and 22 were determined using an enzyme-linked immunosorbent assay (ELISA), and thereafter, levels were correlated with the severity of acne. Result: Serum levels of IL-6, IL-8, IL-17 and IL-22 were 0.15 +/- 0.0174 pg/ml, 0.38 +/- 0.080 pg/ml, 0.19 +/- 0.0075 pg/ml and 0.23 +/- 0.0152 pg/ml in cases, respectively, and 0.13 +/- 0.0095 pg/ml, 0.14 +/- 0.034 pg/ml, 0.13 +/- 0.0033 pg/ml and 0.21 +/- 0.0099 pg/ml in controls, respectively. The difference in levels between cases and controls was significant for IL-8 and IL-17, while for IL-6 and IL-22 the difference was insignificant. There was a highly significant positive correlation between IL-8 and IL-17 levels. IL-6 and IL-8 showed a significant positive correlation with the severity of disease. Conclusion: IL-8 and IL-17 play a critical effector role in the pathogenesis of AV. IL-6-stimulated Th17 cells are likely the major producers of IL-8 in acne lesions.

Automated summary

This study analyzed the role of interleukins (ILs) 6, 8, 17, and 22 in the pathogenesis of acne. Serum levels of IL-6, IL-8, IL-17, and IL-22 were measured and correlated with the severity of acne. The results showed that IL-8 and IL-17 play a critical role in the pathogenesis of acne, while the role of IL-6 and IL-22 is less significant.