Journal
CLINICAL SCIENCE
Volume 129, Issue 4, Pages 345-362Publisher
PORTLAND PRESS LTD
DOI: 10.1042/CS20150223
Keywords
cold storage; hepatocytes; liver microcirculation; liver sinusoidal endothelial cells; LSEC; warm ischaemia
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Funding
- Instituto de Salud Carlos III [FIS PI14/00029]
- Spanish Ministry of Economy and Competitiveness [SAF2012-31238]
- European Funds FEDER
- Instituto de Salud Carlos III
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Ischaemia/reperfusion injury is an important cause of liver damage during surgical procedures such as hepatic resection and liver transplantation, and represents the main cause of graft dysfunction post-transplantation. Molecular processes occurring during hepatic ischaemia/reperfusion are diverse, and continuously include new and complex mechanisms. The present review aims to summarize the newest concepts and hypotheses regarding the pathophysiology of liver ischaemia/reperfusion, making clear distinction between situations of cold and warm ischaemia. Moreover, the most updated therapeutic strategies including pharmacological, genetic and surgical interventions, as well as some of the scientific controversies in the field are described.
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