Journal
CLINICAL SCIENCE
Volume 128, Issue 2, Pages 81-93Publisher
PORTLAND PRESS LTD
DOI: 10.1042/CS20140278
Keywords
injury; pericyte; regeneration; stem cell
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Funding
- Glenn/AFAR Scholarship for Research in the Biology of Aging
- Wake Forest Pepper Center Pilot Project
- Wake Forest Comprehensive Cancer Center
- National Institutes of Health/National Institute on Aging [AG13934, AG15820]
- Wake Forest Claude D. Pepper Older Americans Independence Center [P30-AG21332]
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Perivascular multipotent cells, pericytes, contribute to the generation and repair of various tissues in response to injury. They are heterogeneous in their morphology, distribution, origin and markers, and elucidating their molecular and cellular differences may inform novel treatments for disorders in which tissue regeneration is either impaired or excessive. Moreover, these discoveries offer novel cellular targets for therapeutic approaches to many diseases. This review discusses recent studies that support the concept that pericyte subtypes play a distinctive role in myogenesis, neurogenesis, adipogenesis, fibrogenesis and angiogenesis.
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