An injectable nanocomposite alginate-Ca2+ hydrogel for melittin-assisted Ca2+-overload and photothermal cancer therapy

An injectable nanocomposite alginate-Ca2+ hydrogel embedded with melittin and polyaniline nanofibers was fabricated for Ca2+-overload and photothermal combination cancer therapy. Melittin disrupts the cell membranes and enhances Ca2+ influx significantly, improving Ca2+-overload treatment, while the polyaniline nanofibers endow the hydrogel with glutathione (GSH) depletion and photothermal ability.

Automated summary

An injectable nanocomposite hydrogel with melittin and polyaniline nanofibers was developed for Ca2+-overload and photothermal combination cancer therapy. Melittin enhances Ca2+ influx, while polyaniline nanofibers provide glutathione depletion and photothermal ability to the hydrogel.