ViscY nuclear magnetic resonance experiments for in situ chemical reaction monitoring under spin diffusion conditions

Viscosity-enhanced spectroscopY (ViscY) offers a new way to analyze complex mixtures of time-varying composition. This communication reports the use of the viscous binary solvent DMSO-d(6)/water to induce NMR spin diffusion for in situ chemical reaction monitoring and real-time characterization of a 3-substituted 4-hydroxycoumarin derivative and its side-product.

Automated summary

ViscY offers a new method to analyze time-varying complex mixtures, and this study demonstrates its use in monitoring chemical reactions and characterizing a 3-substituted 4-hydroxycoumarin derivative and its side-product in real-time using the viscous binary solvent DMSO-d(6)/water.