4.6 Article

Evaluating the biological effectiveness of boron neutron capture therapy by using microfluidics-based pancreatic tumor spheroids

Related references

Note: Only part of the references are listed.
Review Radiology, Nuclear Medicine & Medical Imaging

3d tissue models as tools for radiotherapy screening for pancreatic cancer

Gabrielle Wishart et al.

Summary: The efficacy of radiotherapy treatment varies based on tumor microenvironment (TME). Traditional 2D cell culture fails to replicate important TME features. Animal models have realistic in vivo architecture but are time-consuming and costly.

BRITISH JOURNAL OF RADIOLOGY (2021)

Article Oncology

Cancer-associated fibroblasts secrete hypoxia-induced serglycin to promote head and neck squamous cell carcinoma tumor cell growth in vitro and in vivo by activating the Wnt/β-catenin pathway

Junqi Xie et al.

Summary: The study demonstrated that under hypoxia, CAF-secreted SRGN enhances the stemness, chemoresistance, and tumor growth of HNSCC cells, resulting in poor patient prognosis.

CELLULAR ONCOLOGY (2021)

Review Oncology

Targeting and Reprograming Cancer-Associated Fibroblasts and the Tumor Microenvironment in Pancreatic Cancer

Yoshiaki Sunami et al.

Summary: Targeting cancer-associated fibroblasts has been considered a promising therapeutic strategy for pancreatic cancer, yet depleting these cells may have tumor-promoting effects due to their functional heterogeneity. It is therefore important to selectively target the tumor-promoting subtype of cancer-associated fibroblasts to achieve effective treatment outcomes.

CANCERS (2021)

Review Biotechnology & Applied Microbiology

3D Cancer Models: The Need for a Complex Stroma, Compartmentalization and Stiffness

Judith Pape et al.

Summary: The use of tissue-engineered 3D models of cancer has become more popular in cancer research. This review explores different 3D models, outlining their benefits, limitations, and methods for measuring cancer invasion and growth. Tumoroids were found to be comparable 3D cancer models with a high degree of biomimicry.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Article Biology

HIF-1α affects sensitivity of murine squamous cell carcinoma to boron neutron capture therapy with BPA

Yu Sanada et al.

Summary: The study revealed that hypoxia may reduce the effectiveness of boron neutron capture therapy (BNCT) with BPA in murine squamous cell carcinoma cells, while disruption of Hif-1 alpha increased sensitivity to BNCT.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Oncology

Tissue Architecture Influences the Biological Effectiveness of Boron Neutron Capture Therapy in In Vitro/In Silico Three-Dimensional Self-Assembly Cell Models of Pancreatic Cancers

Lin-Sheng Yu et al.

Summary: Boron neutron capture therapy (BNCT) shows promising efficacy against pancreatic cancer, especially when considering the cellular microenvironment. Utilizing in vitro and in silico 3D models, this study reveals that the 3D architecture of pancreatic tumors enhances the susceptibility of cancer cells to BNCT compared to 2D structures. Computer simulations confirm this unexpected finding, supporting the potential for personalized radiotherapy development.

CANCERS (2021)

Article Chemistry, Inorganic & Nuclear

Using salvage Boron Neutron Capture Therapy (BNCT) for recurrent malignant brain tumors in Taiwan

Tien-Li Lan et al.

APPLIED RADIATION AND ISOTOPES (2020)

Review Engineering, Biomedical

Could 3D models of cancer enhance drug screening?

Virginia Brancato et al.

BIOMATERIALS (2020)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Materials Science, Multidisciplinary

Boron nitride (10BN) a prospective material for treatment of cancer by boron neutron capture therapy (BNCT)

Manjot Kaur et al.

MATERIALS LETTERS (2020)

Article Gastroenterology & Hepatology

Pancreatic stellate cells: Aiding and abetting pancreatic cancer progression

Srinivasa P. Pothula et al.

PANCREATOLOGY (2020)

Article Cell Biology

Evaluation of a Novel Boron-Containing α-d-Mannopyranoside for BNCT

Takao Tsurubuchi et al.

CELLS (2020)

Article Chemistry, Inorganic & Nuclear

Evaluation of PHITS for microdosimetry in BNCT to support radiobiological research

N. Hu et al.

APPLIED RADIATION AND ISOTOPES (2020)

Review Cell Biology

CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer

Maria Auxiliadora Olivares-Urbano et al.

CELLS (2020)

Article Nanoscience & Nanotechnology

Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

Guillaume Vares et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

Review Medicine, Research & Experimental

3D approaches to model the tumor microenvironment of pancreatic cancer

Elena Tomas-Bort et al.

THERANOSTICS (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

The essential role of radiobiological figures of merit for the assessment and comparison of beam performances in boron neutron capture therapy

L. Provenzano et al.

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS (2019)

Review Cell & Tissue Engineering

Cell-Cell Mechanical Communication in Cancer

Samantha C. Schwager et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2019)

Article Oncology

Very low intensity ultrasounds as a new strategy to improve selective delivery of nanoparticles-complexes in cancer cells

Rossella Loria et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Oncology

Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors

Prashanth Rawla et al.

WORLD JOURNAL OF ONCOLOGY (2019)

Review Engineering, Biomedical

Design of spherically structured 3D in vitro tumor models -Advances and prospects

L. P. Ferreira et al.

ACTA BIOMATERIALIA (2018)

Article Oncology

Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1

Zike Yang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Article Oncology

The role of cancer-associated fibroblast MRC-5 in pancreatic cancer

Song-Ming Ding et al.

JOURNAL OF CANCER (2018)

Review Biochemical Research Methods

Bringing 3D tumor models to the clinic - predictive value for personalized medicine

Kathrin Halfter et al.

BIOTECHNOLOGY JOURNAL (2017)

Review Biochemical Research Methods

3D Culture as a Clinically Relevant Model for Personalized Medicine

Eliza Li Shan Fong et al.

SLAS TECHNOLOGY (2017)

Review Biochemistry & Molecular Biology

The hypoxic microenvironment: A determinant of cancer stem cell evolution

Amancio Carnero et al.

BIOESSAYS (2016)

Article Cell & Tissue Engineering

Generation of Homogenous Three-Dimensional Pancreatic Cancer Cell Spheroids Using an Improved Hanging Drop Technique

Matthew J. Ware et al.

TISSUE ENGINEERING PART C-METHODS (2016)

Review Oncology

Pathophysiological Basis for the Formation of the Tumor Microenvironment

Michael R. Horsman et al.

FRONTIERS IN ONCOLOGY (2016)

Article Biochemical Research Methods

Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation

Manjulata Singh et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2015)

Review Cell Biology

How cell death shapes cancer

V. Labi et al.

CELL DEATH & DISEASE (2015)

Editorial Material Cell Biology

Escaping death to quiescence: Avoiding mitotic catastrophe after DNA damage

Zhiyuan Shen et al.

CELL CYCLE (2013)

Article Cell Biology

HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression

Chen-Ye Shi et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2013)

Article Biochemistry & Molecular Biology

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

Stephan P. Tenbaum et al.

NATURE MEDICINE (2012)

Review Biochemistry & Molecular Biology

Tumor heterogeneity: Causes and consequences

Andriy Marusyk et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2010)

Article Chemistry, Inorganic & Nuclear

Neutron spectra measurement and comparison of the HFR and THOR BNCT beams

Yuan-Hao Liu et al.

APPLIED RADIATION AND ISOTOPES (2009)

Article Chemistry, Inorganic & Nuclear

Current clinical results of the Tsukuba BNCT trial

T Yamamoto et al.

APPLIED RADIATION AND ISOTOPES (2004)

Article Chemistry, Inorganic & Nuclear

Effectiveness of BNCT for recurrent head and neck malignancies

I Kato et al.

APPLIED RADIATION AND ISOTOPES (2004)

Article Oncology

A critical assessment of boron target compounds for boron neutron capture therapy

MF Hawthorne et al.

JOURNAL OF NEURO-ONCOLOGY (2003)

Article Oncology

Biological response to radiation therapy

I Turesson et al.

ACTA ONCOLOGICA (2003)