Relationship between oxygen partial pressure and inhibition of cell aggregation of human adipose tissue-derived mesenchymal stem cells stored in cell preservation solutions

Review Cell & Tissue Engineering

Efficacy and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis

Wenchun Qu et al.

Summary: MSC cell therapy has the potential to reduce mortality, decrease serious adverse events, and improve pulmonary function in COVID-19 patients.

STEM CELLS TRANSLATIONAL MEDICINE (2022)

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Article Biophysics

Off-the-shelf bone marrow-derived mesenchymal stem cell treatment for acute graft-versus-host disease: real-world evidence

Makoto Murata et al.

Summary: The study presents initial experience with Temcell in a real-world setting for the treatment of acute GVHD, showing promising initial efficacy and suggesting it as a treatment option for steroid-refractory acute GVHD until a new treatment with survival benefit is developed.

BONE MARROW TRANSPLANTATION (2021)

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Article Biology

Protein-free solution containing trehalose and dextran 40 for cryopreservation of human adipose tissue-derived mesenchymal stromal cells

Yasutaka Fujita et al.

Summary: LR-3T-5D proved to be an effective vehicle solution for cryopreservation, maintaining cell viability and functionality. The additive effects of trehalose and dextran 40 as cryoprotectants were dose-dependent. Lowering Me2SO concentration to 5% and washing/replacement with LR-3T and LR-3T-5D after thawing were feasible approaches to sustain cryopreservation efficacy.

CRYOBIOLOGY (2021)

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Article Cell & Tissue Engineering

Umbilical cord mesenchymal stromal cells as critical COVID-19 adjuvant therapy: A randomized controlled trial

Ismail Hadisoebroto Dilogo et al.

Summary: The use of umbilical cord mesenchymal stromal cells (UC-MSCs) as adjuvant treatment for critically ill patients with COVID-19 significantly increases the survival rate by modulating the immune system towards an anti-inflammatory state.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

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Article Cell & Tissue Engineering

The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial

G. Adas et al.

Summary: The aim of the clinical trial was to control cytokine storm by administering MSCs to critically ill COVID-19 patients, evaluating healing effects, and systematically investigating treatment mechanisms. The results showed positive systematic and cellular effects of MSCs application in critically ill patients, playing an important role in curing and reducing mortality.

CELL TRANSPLANTATION (2021)

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Article Cell & Tissue Engineering