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RNA-cleaving DNAzymes for accurate biosensing and gene therapy

NANOSCALE (2023)

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Specific DNAzymes cleave the 300-618 nt of 5′UTR to inhibit DHAV-1 translation and replication

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Spatiotemporally Controlled Ultrasensitive Molecular Imaging Using a DNA Computation-Mediated DNAzyme Platform

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Upconverting nanoparticles based nanodevice for DNAzymes amplified miRNAs detection and artificially controlled chemo-gene therapy

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DNAzyme-Assisted Nano-Herb Delivery System for Multiple Tumor Immune Activation

Shiyu Du et al.

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How EBV Infects: The Tropism and Underlying Molecular Mechanism for Viral Infection

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Summary: This review article discusses the tropism and molecular mechanism of EBV infection. The interactions between the virus and B cells and epithelial cells differ, and the entry process relies on heterogenous glycoprotein-receptor interactions.

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Detection of intracellular sodium ions based on phenotype-specific activation of NaA43 DNAzyme

Lok Ting Chu et al.

Summary: This study reported a method for detecting intracellular sodium ions by activating DNAzyme through endogenous mRNA, successfully achieving the detection of sodium ions in different phenotypic cells and observing an increase in their levels by increasing the permeability of the cell membrane.

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Article Engineering, Environmental

A double DNAzyme-loaded MnO2 versatile nanodevice for precise cancer diagnosis and Self-Sufficient synergistic gene therapy

Weipan Peng et al.

Summary: This study reports a multifunctional nanodevice for inhibiting tumor angiogenesis and promoting apoptosis. By precise multimodal imaging, the dual genes involved in tumor growth were silenced, effectively inhibiting tumor progression. This research has important clinical implications for cancer therapy.

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Article Chemistry, Multidisciplinary

High-fidelity ATP imaging via an isothermal cascade catalytic amplifier

Zhiqiao Zou et al.

Summary: By combining tumor-responsive nanoparticles with a specific stimuli-activated cascade DNA amplifier, this study proposes a platform for multiply guaranteed and amplified ATP sensing. The platform achieves sensitive analysis of low-abundance ATP in cancer cells and also enables tumor-specific activated photodynamic therapy.

CHEMICAL SCIENCE (2022)

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Article Chemistry, Analytical

A Cooperatively Activatable DNA Nanoprobe for Cancer Cell-Selective Imaging of ATP

Yizhuo Zhou et al.

Summary: DNA-based nanoprobes, specifically designed to respond to multiple pathological parameters such as GSH and ATP, exhibit high stability and specificity in detecting and imaging ATP within cancer cells, showing potential for accurate disease diagnosis and biochemical research.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

Metal-Organic Framework Nanoparticles Power DNAzyme Logic Circuits for Aberrant MicroRNA Imaging

Juan Zhang et al.

Summary: In this study, DNAzyme logic circuits were constructed for the analysis and imaging of multiple microRNAs in living cells using Cu/ZIF-8 NPs as a nanocarrier. The logic gate modules of the system were efficiently released by pH-responsive Cu/ZIF-8 NPs, allowing for multiple logic computations initiated by endogenous miRNA. This research provides a new method for the application of DNA biocomputing circuits in living cells.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

Smart Catalyzed Hairpin Assembly-Induced DNAzyme Nanosystem for Intracellular UDG Imaging

Xiaolei Song et al.

Summary: A smart catalyzed hairpin assembly (CHA) DNAzyme nanosystem has been developed for intracellular UDG imaging, utilizing MnO2 nanosheets as nanocarriers to efficiently deliver DNA probes into cells and promote the fluorescence resonance energy transfer response. This approach offers enhanced sensitivity for early-stage cancer prediction and diagnosis.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

An Enzyme-Activatable Engineered DNAzyme Sensor for Cell-Selective Imaging of Metal Ions

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Summary: Li et al. achieved cell-selective imaging of metal ions using an enzyme-activatable DNAzyme sensor technology, allowing differentiation of metal-ion signals in tumor cells from healthy cells both in vitro and in vivo.

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All-sealed paper-based electrochemiluminescence platform for on-site determination of lead ions

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Summary: An all-sealed paper-based electrochemiluminescence platform was developed for sensitive analysis of lead ions, combining convenient plastic packaging technology. The platform achieved wide linear relationship and low detection limit for rapid detection of heavy metal ions, showing promise for on-site contamination analysis in the future.

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Photo-gated and self-powered three-dimensional DNA motors with boosted biostability for exceptionally precise and efficient tracing of intracellular survivin mRNA

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Editorial Material Oncology

Uncovering the Immunoregulatory Function and Therapeutic Potential of the PD-1/PD-L1 Axis in Cancer

Michael R. Pitter et al.

Summary: The article demonstrates that immune checkpoint blockade can enhance the response of tumor-specific T cells against tumor cells, effectively increasing tumor cell lysis, and provides scientific rationale for a new generation of cancer treatment targeting the PD-1/PD-L1 signaling pathway in the tumor microenvironment.

CANCER RESEARCH (2021)

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Correction Nanoscience & Nanotechnology

Inhibition of Proliferation and Migration of Tumor Cells Through Phenylboronic Acid-Functionalized Polyamidoamine-Mediated Delivery of a Therapeutic DNAzyme Dz13 (vol 14, pg 6371, 2019)

J. Yang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Nanoscience & Nanotechnology

DNAzyme Amplified Aptasensing Platform for Ochratoxin A Detection Using a Personal Glucose Meter

Songbai Zhang et al.

Summary: In this study, an aptamer-based sensing platform incorporating magnetic beads and a DNAzyme for signal amplification was developed for the detection of small-molecular targets, showing high sensitivity and good selectivity. By conjugating biotin-labeled aptamer probe and substrate strand on magnetic beads, and hybridizing DNAzyme strand to block substrate cleavage, specific binding of small-molecular targets can be detected and quantified effectively through an iterative signal amplification reaction. This platform enables the detection of toxins such as ochratoxin with a wide linear detection range, low detection limit, and the potential for portable, at-home analysis of small molecules using a glucose meter.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

A Self-Catabolic Multifunctional DNAzyme Nanosponge for Programmable Drug Delivery and Efficient Gene Silencing

Jing Wang et al.

Summary: We designed a self-catabolic DNA nanocapsule for sustained activation of therapeutic DNAzyme in cancer cells, utilizing a hierarchical rolling circle replication (RCR) nanostructure. Through tumor-anchoring aptamer strands, the nanocapsule was specifically accumulated in cancer cells and sequentially activated for gene silencing. By employing a programmable RCR assembly strategy, our DNAzyme nanoplatform shows promise for developing smart gene therapeutics and personalized nanomedicines.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Immunology

An Overview of the NF-kB mechanism of pathophysiology in rheumatoid arthritis, investigation of the NF-kB ligand RANKL and related nutritional interventions

Desislava (Daisy) Ilchovska et al.

Summary: NF-kB and RANKL play important roles in RA, with potential side effects from long-term non-specific suppression of the NF-kB pathway. Vitamin D supplementation may help to lower RANKL levels, serving as a potential nutrition intervention for RA management.

AUTOIMMUNITY REVIEWS (2021)

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Article Chemistry, Analytical

Autocatalytic MNAzyme-integrated surface plasmon resonance biosensor for simultaneous detection of bacteria from nosocomial bloodstream infection specimens

Han Xia et al.

Summary: The study introduces a novel autocatalytic MNAzyme-integrated SPR biosensor assay for rapid and sensitive detection of DNA from pathogenic bacteria causing nBSIs.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Enzyme-free dual-DNA walker based on catalytic hairpin assembled DNAzyme for sensing telomerase activity

Yong Shen et al.

Summary: This study presents a highly sensitive strategy for detecting telomerase activity using a dual-3D DNA walker with enzyme-free and isothermal fluorescence detection. The strategy shows a wide application range in different tumor cells and is able to detect telomerase activity in human serum.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Multidisciplinary

Photoactivated Self-Disassembly of Multifunctional DNA Nanoflower Enables Amplified Autophagy Suppression for Low-Dose Photodynamic Therapy

Jinjin Shi et al.

Summary: The multifunctional DNA nanoflower developed in this study can target tumor cells specifically, enhance autophagy suppression, and potentially serve as a safe low-dose photodynamic therapy strategy for cancer treatment.

SMALL (2021)

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Article Chemistry, Multidisciplinary

Self-Assembly of Copper-DNAzyme Nanohybrids for Dual-Catalytic Tumor Therapy

Congzhi Liu et al.

Summary: A novel hybrid nanostructure was developed in this study, delivering DNAzyme and Cu2+ to cancer cells for combinational therapy. The system demonstrated significant antitumor effects in tumors through catalytic cleavage of VEGFR2 mRNA and chemodynamic therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Physical

Assembly of multifunction dyes and heat shock protein 90 inhibitor coupled to bovine serum albumin in nanoparticles for multimodal photodynamic/photothermal/chemo-therapy

Zhenfu Wen et al.

Summary: This study explores a treatment strategy combining photothermal therapy and chemotherapy to promote apoptosis in cancer cells by inhibiting the overexpression of Hsp-90 and survivin.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Chemistry, Multidisciplinary

A biologically stable DNAzyme that efficiently silences gene expression in cells

Yajun Wang et al.

Summary: Efforts to use RNA-cleaving DNA enzymes as gene-silencing agents have been hindered by low efficacy in clinical trials, but a new xeno-nucleic-acid-modified DNAzyme called X10-23 has shown promise in achieving multiple-turnover activity and resisting nuclease digestion in cellular conditions. X10-23 overcomes product inhibition and facilitates persistent gene silencing in mammalian cells, suggesting new molecular chemotypes can enhance the activity and stability of DNAzymes for potential therapeutic applications.

NATURE CHEMISTRY (2021)

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Article Chemistry, Analytical

DNAzyme walker induced DNAzyme working cascade signal amplification strategy for sensitive detection of protein

Liyan Zhang et al.

Summary: A sensitive DNAzyme cascade signal amplification strategy was developed for the sensitive detection of disease-related protein thrombin, achieving high sensitivity and a wide linear range. The cascade amplification effect significantly improved the detection sensitivity, providing a new method for sensitive protein analysis.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Target-triggered DNAzyme walker with 3D walking unit for copper species sensing in serum: A multivalent binding strategy for improving the detection performance

Lihong Zhou et al.

Summary: A target-triggered DNAzyme walker was designed for sensitive detection of copper species in bio-samples. The use of MBs@Cu-Enzy walking unit exhibited higher cleavage efficiency, shorter detection time, and lower limit of detection compared to other walking units, due to multivalent interactions between the 3D track and the 3D walking unit. Good accuracy was observed for copper species analysis in clinical serum samples, indicating potential indicators for the auxiliary diagnosis of Cu-related disorders.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Near-infrared light excited UCNP-DNAzyme nanosensor for selective detection of Pb2+ and in vivo imaging

Linna Huang et al.

Summary: A DNAzyme-based nanosensor utilizing near-infrared excitation was developed for sensitive and selective detection of Pb2+, showing potential for in vivo imaging in living cells and zebrafish.

TALANTA (2021)

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Article Multidisciplinary Sciences

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

Emily L. Giddings et al.

Summary: Chemotherapy is the standard treatment for most cancers worldwide, but chemoresistance due to ABC transporters is a significant challenge. The study highlights the role of mitochondrial respiration in supplying ATP for ABC transporters, and how inhibiting mitochondrial respiration can overcome chemoresistance. Development of MCJ mimetics offers a potential alternative strategy for treating multiple cancers by targeting this mechanism.

NATURE COMMUNICATIONS (2021)

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Article Nanoscience & Nanotechnology

Light-Activated and Self-Driven Autonomous DNA Nanomachine Enabling Fluorescence Imaging of MicroRNA in Living Cells with Exceptional Precision and Efficiency

Jia-Ling Gao et al.

Summary: By introducing light-triggered walking behavior and encapsulating within a dissociable metal-organic framework, the challenges facing DNA nanomachine-supported biosensors in intracellular fluorescence imaging have been successfully overcome, while also improving sensitivity and specificity.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

DNAzyme-Based Biosensors: Immobilization Strategies, Applications, and Future Prospective

Shadman Khan et al.

Summary: DNAzymes have been extensively used in biosensors as molecular recognition elements or reporters, with immobilization strategy selection being crucial for sensor accuracy and sensitivity. Various immobilization approaches for DNAzymes within biosensors have been employed, with the selection of an appropriate strategy largely dependent on the desired application.

ACS NANO (2021)

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Article Chemistry, Analytical

Programming a Crab Claw-like DNA Nanomachine as a Super Signal Amplifier for Ultrasensitive Electrochemical Assay of Hg2+

Yuanyuan Chang et al.

Summary: A Crab Claw-like DNA nanomachine was engineered with stable T-Hg2+-T bonding for ultrasensitive electrochemical assay of mercury ions, showing a low limit of detection. The combination with multimetallic mesoporous nanomaterials enhanced the electrochemical signal for heavy metal ion detection, demonstrating promising application potential.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Rapid and Specific Imaging of Extracellular Signaling Molecule Adenosine Triphosphate with a Self-Phosphorylating DNAzyme

Dan Zhao et al.

Summary: In this study, a self-phosphorylating DNAzyme sensor was developed for fluorescence imaging of ATP, showing subsecond response kinetics, high specificity, and micromolar affinities. This sensor was demonstrated to be effective for visualizing ATP signaling in various cellular processes, such as stress-induced endogenous ATP release and mechanical stimulation-evoked ATP release.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Meeting Abstract Oncology

FUNCTION AND DEPENDENCY OF NF-KB ACTIVITY IN C11ORF95-RELA FUSION EPENDYMOMA

Austin Stuckert et al.

NEURO-ONCOLOGY (2021)

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Review Chemistry, Multidisciplinary

Biosensing with DNAzymes

Erin M. McConnell et al.

Summary: This article provides a comprehensive review of biosensing with DNAzymes, highlighting major progress and contributions to portable biosensor devices and point-of-care diagnostics. It specifically focuses on the incorporation of DNAzymes into bioassays and recent advances in in vivo sensing platforms and portable sensors for molecular recognition, concluding with a critical perspective on the field and potential impacts of DNAzyme-based devices.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Extracellular matrix and its therapeutic potential for cancer treatment

Jiacheng Huang et al.

Summary: The extracellular matrix (ECM) is a key component of tumors, playing roles in mechanical support, microenvironment modulation, and signaling. Interactions between cancer cells and the tumor microenvironment can lead to ECM stiffness changes and contribute to malignant transformation. Understanding ECM dysregulation in the TME is essential for identifying therapeutic targets for cancer treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Chemistry, Analytical

A label-free fluorescent aptasensor based on HCR and G-quadruplex DNAzymes for the detection of prostate-specific antigen

Ruirui Zhao et al.

Summary: A label-free fluorescence aptasensing strategy for detecting PSA based on HCR and G-quadruplex DNAzymes was developed, with a low detection limit of 0.05 nM and a wide linear range from 0.1 nM to 1 nM. The sensor showed strong selectivity towards PSA detection, with no significant interference from other proteins, and was successfully applied to diluted serum samples.

ANALYST (2021)

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Article Chemistry, Multidisciplinary

DNAzyme-adsorbed polydopamine@MnO2 core-shell nanocomposites for enhanced photothermal therapy via the self-activated suppression of heat shock protein 70

Yang Xi et al.

Summary: A flower-like MnO2-coated core-shell nanoplatform was developed for enhanced photothermal therapy (PTT) by silencing HSP70 gene, resulting in suppressed tumor growth and induced tumor cell apoptosis.

NANOSCALE (2021)

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Article Chemistry, Multidisciplinary

Enzyme-Mediated Tumor Starvation and Phototherapy Enhance Mild-Temperature Photothermal Therapy

Ge Gao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Smart, Autocatalytic, DNAzyme Biocircuit for in Vivo, Amplified, MicroRNA Imaging

Jie Wei et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Nanoscience & Nanotechnology

Multifunctional DNA Polymer-Assisted Upconversion Therapeutic Nanoplatform for Enhanced Photodynamic Therapy

Yi Jin et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Analytical

MicroRNA-Initiated and Intracellular Na+-Fueled DNAzyme Motor for Differentiating Molecular Subtypes of Nonsmall Cell Lung Cancer

Kun Chen et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Biodegradable Metal-Organic Frameworks Power DNAzyme for in Vivo Temporal-Spatial Control Fluorescence Imaging of Aberrant MicroRNA and Hypoxic Tumor

Xiangdan Meng et al.

ANALYTICAL CHEMISTRY (2020)

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Article Biophysics

Selection of a metal ligand modified DNAzyme for detecting Ni2+

Wei Ren et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Biochemistry & Molecular Biology

Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer

Nora Feldker et al.

EMBO JOURNAL (2020)

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Article Biophysics

Ultrasensitive magnetic DNAzyme-copper nanoclusters fluorescent biosensor with triple amplification for the visual detection of E. coli O157: H7

Ziqi Zhou et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Review Oncology

Advances in Anti-Cancer Immunotherapy: Car-T Cell, Checkpoint Inhibitors, Dendritic Cell Vaccines, and Oncolytic Viruses, and Emerging Cellular and Molecular Targets

Emilie Alard et al.

CANCERS (2020)

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Article Immunology

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer

Maria Victoria Recouvreux et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Pharmacology & Pharmacy

ROS-boosted photodynamic therapy against metastatic melanoma by inhibiting the activity of antioxidase and oxygen-producing nano-dopants

Jie Zhou et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Pharmacology & Pharmacy

Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistance

Nir Shahar et al.

DRUG RESISTANCE UPDATES (2020)

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Article Engineering, Environmental

Liquid crystal-based sensing platform for detection of Pb2+ assisted by DNAzyme and rolling circle amplification

Jie Liu et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Biophysics

Single-step electrochemical sensing of ppt-level lead in leaf vegetables based on peroxidase-mimicking metal-organic framework

Xinai Zhang et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Chemistry, Multidisciplinary

An intelligent nanodevice based on the synergistic effect of telomerase-triggered photodynamic therapy and gene-silencing for precise cancer cell therapy

Jin-Tao Yi et al.

NANOSCALE (2020)

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Article Materials Science, Biomaterials

Cationic copolymer enhances 8-17 DNAzyme and MNAzyme activities

Krittika Rudeejaroonrung et al.

BIOMATERIALS SCIENCE (2020)

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Review Pharmacology & Pharmacy

The extracellular matrix as a key regulator of intracellular signalling networks

Jordan F. Hastings et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

Therapeutic Potential of DNAzyme Loaded on Chitosan/Cyclodextrin Nanoparticle to Recovery of Chemosensitivity in the MCF-7 Cell Line

Elham Zokaei et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2019)

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Review Oncology

Viral-Targeted Strategies Against EBV-Associated Lymphoproliferative Diseases

Kwai Fung Hui et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Chemistry, Analytical

Programming a Target-Initiated Bifunctional DNAzyme Nanodevice for Sensitive Ratiometric Electrochemical Biosensing

Yunrui Li et al.

ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

ADNAzyme- Based Colorimetric Paper Sensor for Helicobacter pylori

M. Monsur Ali et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Chemistry, Multidisciplinary

Molecular pathways in cancer response to photodynamic therapy

Valentina Rapozzi et al.

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES (2019)

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Article Oncology

The medical necessity of advanced molecular testing in the diagnosis and treatment of brain tumor patients

Craig Horbinski et al.

NEURO-ONCOLOGY (2019)

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Article Oncology

Role of angiogenesis in melanoma progression: Update on key angiogenic mechanisms and other associated components

Woo Cheal Cho et al.

SEMINARS IN CANCER BIOLOGY (2019)

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Article Chemistry, Analytical

A triply amplified electrochemical lead(II) sensor by using a DNAzyme and via formation of a DNA-gold nanoparticle network induced by a catalytic hairpin assembly

Xiaolei Song et al.

MICROCHIMICA ACTA (2019)

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Article Chemistry, Analytical

MnO2-DNAzyme-photosensitizer nanocomposite with AIE characteristic for cell imaging and photodynamic-gene therapy

Xudong Wang et al.

TALANTA (2019)

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Review Chemistry, Multidisciplinary

Engineering State-of-the-Art Plasmonic Nanomaterials for SERS-Based Clinical Liquid Biopsy Applications

Jing Wang et al.

ADVANCED SCIENCE (2019)

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Review Chemistry, Multidisciplinary

Technological Challenges and Future Issues for the Detection of Circulating MicroRNAs in Patients With Cancer

Jean Cacheux et al.

FRONTIERS IN CHEMISTRY (2019)

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Article Cardiac & Cardiovascular Systems

Impaired endogenous fibrinolysis in ST-segment elevationmyocardial infarction patients undergoing primary percutaneous coronary intervention is a predictor of recurrent cardiovascular events: the RISK PPCI study

Mohamed Farag et al.

EUROPEAN HEART JOURNAL (2019)

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Review Cell Biology

EMT Transition States during Tumor Progression and Metastasis

Ievgenia Pastushenko et al.

TRENDS IN CELL BIOLOGY (2019)

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Article Materials Science, Biomaterials

A new insight into the reversal of multidrug resistance in cancer by nanodrugs

Huangyong Jiang et al.

BIOMATERIALS SCIENCE (2019)

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Article Chemistry, Analytical

Silver-ion-mediated Mg2+-dependent DNAzyme activity for amplified fluorescence detection of cysteine

Xu-Hua Zhao et al.

ANALYST (2019)

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Article Oncology

Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma

Jing Meng et al.

CANCER RESEARCH (2018)

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Editorial Material Oncology

IMMUNOTHERAPY Cancer immunotherapy and the value of cure

Joseph C. Del Paggio

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

Melanoma protective antitumor immunity activated by catalytic DNA

Hong Cai et al.

ONCOGENE (2018)

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Article Materials Science, Multidisciplinary

Deoxyribozyme-nanosponges for improved photothermal therapy by overcoming thermoresistance

Yi Jin et al.

NPG ASIA MATERIALS (2018)

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Review Virology

The Epstein-Barr virus LMP1 interactome: biological implications and therapeutic targets

Mujeeb R. Cheerathodi et al.

FUTURE VIROLOGY (2018)

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Article Chemistry, Multidisciplinary

Optical Control of Metal Ion Probes in Cells and Zebrafish Using Highly Selective DNAzymes Conjugated to Upconversion Nanoparticles

Zhenglin Yang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Article Materials Science, Biomaterials

A NIR-light activated nanoplatform for sensitizing triple negative breast cancer against therapeutic resistance to enhance the treatment effect

Xiaojing Sun et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Review Cell Biology

Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

Tong Chen et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

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Meeting Abstract Oncology

Evaluating collagen neoepitopes as pharmacodynamic biomarkers of GS-5745, an MMP9 inhibitor, in advanced gastric cancer.

Carrie Baker Brachmann et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Chemistry, Multidisciplinary

Overcoming photodynamic resistance and tumor targeting dual-therapy mediated by indocyanine green conjugated gold nanospheres

Wei Li et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Biochemistry & Molecular Biology

MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer

Zhuo-yuan Lin et al.

MOLECULAR CANCER (2017)

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Review Chemistry, Multidisciplinary

Recent advances in DNAzyme-based gene silencing

Huanhuan Fan et al.

SCIENCE CHINA-CHEMISTRY (2017)

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Article Multidisciplinary Sciences

Crystal structure of an RNA-cleaving DNAzyme

Hehua Liu et al.

NATURE COMMUNICATIONS (2017)

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Article Medicine, Research & Experimental

Theranostic DNAzymes

Wenhu Zhou et al.

THERANOSTICS (2017)

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Article Nanoscience & Nanotechnology

A co-delivery nanosystem of chemotherapeutics and DNAzyme overcomes cancer drug resistance and metastasis

Shu-Pin Sun et al.

NANO FUTURES (2017)

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Review Chemistry, Multidisciplinary

Discovery and Biosensing Applications of Diverse RNA-Cleaving DNAzymes

Meng Liu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

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Article Biophysics

Metal-ion dependent DNAzyme recycling amplification for sensitive and homogeneous immuno-proximity binding assay of α-fetoprotein biomarker

Mengqi Zou et al.

BIOSENSORS & BIOELECTRONICS (2017)

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Review Biophysics

Recent advances in biosensor development for the detection of cancer biomarkers

V. S. P. K. Sankara Aditya Jayanthi et al.

BIOSENSORS & BIOELECTRONICS (2017)

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Review Biochemistry & Molecular Biology

Emerging Biological Principles of Metastasis

Arthur W. Lambert et al.

CELL (2017)

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Article Medicine, General & Internal

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults 2016 Recommendations of the International Antiviral Society-USA Panel

Huldrych F. Gunthard et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Article Multidisciplinary Sciences

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer

Sherry Y. Wu et al.

NATURE COMMUNICATIONS (2016)

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Meeting Abstract Oncology

Tyrosine kinase inhibitors to regulate the expression level of ABC transporters related to multidrug resistance

Martin Klabusay et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

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Review Biotechnology & Applied Microbiology

DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes

Alesya A. Fokina et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2015)

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Article Oncology

EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

Lifang Yang et al.

ONCOTARGET (2015)

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Article Oncology

DCE-MRI assessment of the effect of Epstein-Barr virus-encoded latent membrane protein-1 targeted DNAzyme on tumor vasculature in patients with nasopharyngeal carcinomas

Wei-Hua Liao et al.

BMC CANCER (2014)

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Article Oncology

Targeting EBV-LMP1 DNAzyme enhances radiosensitivity of nasopharyngeal carcinoma cells by inhibiting telomerase activity

Lifang Yang et al.

CANCER BIOLOGY & THERAPY (2014)

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Article Chemistry, Medicinal

Activity of Core-Modified 10-23 DNAzymes against HCV

Laura Robaldo et al.

CHEMMEDCHEM (2014)

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Article Biotechnology & Applied Microbiology

Therapeutic Evaluation of Epstein-Barr Virusencoded Latent Membrane Protein-1 Targeted DNAzyme for Treating of Nasopharyngeal Carcinomas

Ya Cao et al.

MOLECULAR THERAPY (2014)

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Article Cardiac & Cardiovascular Systems

Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)

Yue Li et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

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Article Oncology

EBV-LMP1-targeted DNAzyme induces DNA damage and causes cell cycle arrest in LMP1-positive nasopharyngeal carcinoma cells

Xiaoqian Ma et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2013)

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Article Medicine, Research & Experimental

An Egr-1-specific DNAzyme regulates Egr-1 and proliferating cell nuclear antigen expression in rat vascular smooth muscle cells

Junbiao Zhang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2013)

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Article Oncology

Anti-matrix metalloproteinase-9 DNAzyme decreases tumor growth in the MMTV-PyMT mouse model of breast cancer

Miranda A. Hallett et al.

BREAST CANCER RESEARCH (2013)

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Article Engineering, Biomedical

Functional delivery of DNAzyme with iron oxide nanoparticles for hepatitis C virus gene knockdown

Soo-Ryoon Ryoo et al.

BIOMATERIALS (2012)

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Article Biology

Inhibition of HIV-1 Integrase gene expression by 10-23 DNAzyme

Nirpendra Singh et al.

JOURNAL OF BIOSCIENCES (2012)

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Article Oncology

Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion

Ravinay Bhindi et al.

JOURNAL OF PATHOLOGY (2012)

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Article Biochemistry & Molecular Biology

Nucleic Acid-Mediated Cleavage of M1 Gene of Influenza A Virus Is Significantly Augmented by Antisense Molecules Targeted to Hybridize Close to the Cleavage Site

B. Kumar et al.

MOLECULAR BIOTECHNOLOGY (2012)

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Article Cell Biology

DNAzyme Targeting c-jun Suppresses Skin Cancer Growth

Hong Cai et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

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Article Hematology

Impaired fibrinolytic capacity and increased fibrin formation associate with myocardial infarction

Karin Leander et al.

THROMBOSIS AND HAEMOSTASIS (2012)

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Article Biotechnology & Applied Microbiology

IGF-II inhibitory DNAzymes inhibit the invasion and migration of hepatocarcinoma cells

Zhang Min et al.

BIOTECHNOLOGY LETTERS (2011)

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Article Oncology

EBV-LMP1-targeted DNAzyme restrains nasopharyngeal carcinoma growth in a mouse C666-1 xenograft model

Xia Ke et al.

MEDICAL ONCOLOGY (2011)

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Review Biochemistry & Molecular Biology

A Therapeutic Approach to Nasopharyngeal Carcinomas by DNAzymes Targeting EBV LMP-1 Gene

Lifang Yang et al.

MOLECULES (2010)

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Review Cell Biology

TGF-β-induced epithelial to mesenchymal transition

Jian Xu et al.

CELL RESEARCH (2009)

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Article Gastroenterology & Hepatology

Site-specific cleavage of HCV genomic RNA and its cloned core and NS5B genes by DNAzyme

Deepak Kumar et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2009)

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Article Oncology

DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radio sensitivity in nasopharyngeal carcinoma

Zhong-Xin Lu et al.

CANCER LETTERS (2008)

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Article Biotechnology & Applied Microbiology

Sequence-specific cleavage of hepatitis C virus RNA by DNAzymes: inhibition of viral RNA translation and replication

Swagata Roy et al.

JOURNAL OF GENERAL VIROLOGY (2008)

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Article Cardiac & Cardiovascular Systems

A DNA enzyme against plasminogen activator inhibitor-type 1 (PAI-1) limits neointima formation after Angioplasty in an obese diabetic rodent model

Piotr Witkowski et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2007)

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Article Virology

Inhibition of respiratory syncytial virus of subgroups A and B using deoxyribozyme DZ1133 in mice

Juan Zhou et al.

VIRUS RESEARCH (2007)

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Article Oncology

Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response

Angela Ferrario et al.

CANCER RESEARCH (2007)

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Article Biochemistry & Molecular Biology

Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression

Ketki M. Hatle et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

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Article Pharmacology & Pharmacy

Inhibition of hepatitis B virus X gene expression by 10-23 DNAzymes

Wei Hou et al.

ANTIVIRAL RESEARCH (2006)

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Article Pharmacology & Pharmacy

Inhibition of respiratory syncytial virus in cultured cells by nucleocapsid gene targeted deoxyribozyme (DNAzyme)

Yuan-Yuan Xie et al.

ANTIVIRAL RESEARCH (2006)

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Article Hematology

DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats

R. Bhindi et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2006)

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Article Cardiac & Cardiovascular Systems

Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularization and reduces cardiomyocyte apoptosis after acute myocardial infarction

GS Xiang et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)

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Article Biotechnology & Applied Microbiology

Effect of EBV LMP1 targeted DNAzymes on cell proliferation and apoptosis

ZX Lu et al.

CANCER GENE THERAPY (2005)

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Article Gastroenterology & Hepatology

Effective inhibition of expression of hepatitis B virus genes by DNAzymes

Jian-Er Wo et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2005)

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Review Oncology

Control of oncogenesis and cancer therapy resistance

R Perona et al.

BRITISH JOURNAL OF CANCER (2004)

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Article Immunology

Down-regulation of plasminogen activator inhibitor 1 expression promotes myocardial neovascularization by bone marrow progenitors

GS Xiang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

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Article Cardiac & Cardiovascular Systems

Vein graft arterialization causes differential activation of mitogen-activated protein kinases

PC Saunders et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2004)

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Article Biochemistry & Molecular Biology

c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury - Inhibition by a novel DNA enzyme targeting c-Jun

LM Khachigian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Hematology

Catalytic antisense DNA molecules targeting Egr-1 inhibit neointima formation following permanent ligation of rat common carotid arteries

HC Lowe et al.

THROMBOSIS AND HAEMOSTASIS (2002)

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Article Cardiac & Cardiovascular Systems

Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis

HC Lowe et al.

CIRCULATION RESEARCH (2001)

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Review Multidisciplinary Sciences

Genome maintenance mechanisms for preventing cancer

JHJ Hoeijmakers

NATURE (2001)

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Article Pharmacology & Pharmacy

Targeted cleavage of HIV-1 coreceptor-CXCR-4 by RNA-cleaving DNA-enzyme: inhibition of coreceptor function

S Basu et al.

ANTIVIRAL RESEARCH (2000)

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Article Agriculture, Multidisciplinary

Label-Free Fluorescence Sensing Strategy Based on Functional Nucleic Acids via Energy Transfer between DNA-Templated Silver Nanoclusters and Gold Nanorods

Junyang Wang et al.

Summary: A simple and low-cost fluorescence signal-on sensing strategy based on functional nucleic acids (FNAs) has been developed for detecting analytes such as tetracycline and Pb2+. This strategy has excellent specificity and sensitivity, and has been successfully applied to detect contaminants in food and environmental samples.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

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