Consecutive regulation of catalytic activities of B(C6F5)3•H2O: direct nucleophilic substitution of benzyl fluorides with alcohol via dual activation

In order to better understand the activity of boron catalysts, the synthesis of novel structural variants is an important task in boron chemistry, but this could be time-consuming and laborious. Herein we developed a simple strategy for the consecutive regulation of the catalytic activity of B(C6F5)(3)& BULL;H2O. The acidity of boron water can be changed consecutively by simply adding an appropriate amount of tetrahydrofuran. At the same time, a challenging nucleophilic substitution of benzyl fluoride with alcohol was performed to demonstrate the superiority of this strategy.

Automated summary

To better understand the activity of boron catalysts, synthesizing new structural variants is an important task in boron chemistry. This study introduces a simple strategy to consecutively regulate the catalytic activity of B(C6F5)3& H2O by adding an appropriate amount of tetrahydrofuran. The superiority of this strategy is demonstrated through a challenging nucleophilic substitution reaction of benzyl fluoride with alcohol.