4.6 Article

Spastin is required for human immunodeficiency virus-1 efficient replication through cooperation with the endosomal sorting complex required for transport (ESCRT) protein

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Clinical and genetic spectra of 1550 index patients with hereditary spastic paraplegia

Jean-Loup Mereaux et al.

Summary: This study reports the clinical and genetic results of a large cohort of patients with hereditary spastic paraplegia. A causative variant was found in 30.7% of the patients, with SPAST and SPG7 being the most frequently mutated genes. A two-step strategy combining gene panels and whole-exome sequencing is proposed to improve the diagnostic yield.

BRAIN (2022)

Article Biochemistry & Molecular Biology

Precise control of microtubule disassembly in living cells

Grace Y. Liu et al.

Summary: Microtubules, a crucial cellular structure, have been studied using chemo and optogenetics methods to disassemble specific types of microtubules. The results provide insights into their roles in cellular trafficking, organelle reorganization, and cell stiffness.

EMBO JOURNAL (2022)

Article Virology

Characterization of human IgM and IgG repertoires in individuals with chronic HIV-1 infection

Xiaolong Tian et al.

Summary: This study systematically analyzed the differences between the IgM (HIV-IgM) and IgG (HIV-IgG) heavy chain repertoires of HIV-1 infected patients and the antibody repertoires of HIV-1 patients and healthy donors (HH). The findings showed that HIV-1 infection has a profound effect on human antibody repertoires, including reduced diversity and increased somatic mutation rates. The study provides valuable insights into the impact of HIV-1 infection and may contribute to the development of therapeutic antibodies.

VIROLOGICA SINICA (2022)

Article Biochemistry & Molecular Biology

A newly identified NES sequence present in spastin regulates its subcellular localization and microtubule severing activity

Kumi Sakoe et al.

Summary: Spastin is a microtubule-severing AAA ATPase that plays important roles in cell division and neurogenesis, with mutations in the SPAST gene leading to neurodegenerative disorders. The two main isoforms of Spastin, M1 and M87, differ in their N-terminal amino acids and have alternative splicing variants. A newly identified NES region containing exon4 regulates the subcellular localization of Spastin in coordination with NLS controlled by phosphorylation state.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Article Neurosciences

Spastin Interacts with CRMP2 to Regulate Neurite Outgrowth by Controlling Microtubule Dynamics through Phosphorylation Modifications

Sumei Li et al.

Summary: The study aims to reveal the microtubule mechanism of neurites outgrowth during neuronal development and suggests an intervention pathway for reconstructing neural network connections after nerve injury. It was shown that the interaction between CRMP2 and spastin promotes neurite outgrowth and branch formation, and the microtubule-severing activity of spastin is essential for this process.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2021)

Review Virology

The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle

Bo Meng et al.

Summary: Viruses are obligate parasites that rely on host cellular factors for replication and spread, often hijacking host machinery such as the ESCRT system. Research on ESCRT and viruses has advanced our understanding of various cellular functions, with a special focus on the interplay between the ESCRT pathway and enveloped viruses like retroviruses.

VIRUSES-BASEL (2021)

Article Biochemistry & Molecular Biology

Histone chaperone CAF-1 promotes HIV-1 latency by leading the formation of phase-separated suppressive nuclear bodies

Xiancai Ma et al.

Summary: HIV-1 latency is a major challenge in achieving a functional cure for AIDS, and the histone chaperone CAF-1 plays a crucial role in maintaining this latency. Disruption of phase-separated CAF-1 bodies could be a potential strategy for reactivating latent HIV-1.

EMBO JOURNAL (2021)

Review Virology

When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding

Kevin M. Rose

Summary: Proper assembly and dissemination of progeny virions is crucial for virus replication, with viruses evolving various strategies to exploit cellular mechanisms for successful infection. Different viruses, such as retroviruses and herpesviruses, utilize host ESCRT complexes in distinct ways to ensure viral particle formation. Despite occurring in separate subcellular compartments and at different steps, the role of ESCRTs in viral lifecycles appears to be conserved.

VIRUSES-BASEL (2021)

Review Cell Biology

HIV-1 Hijacking of Host ATPases and GTPases That Control Protein Trafficking

Lucas A. Tavares et al.

Summary: The human immunodeficiency virus (HIV-1) manipulates host cell machinery by hijacking ATPases, GTPases, and associated proteins to ensure efficient replication and immune evasion.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Virology

Suppression of HIV-1 Integration by Targeting HIV-1 Integrase for Degradation with A Chimeric Ubiquitin Ligase

Zuopeng Zhang et al.

Summary: Our study successfully designed and constructed a series of chimeric E3 ligases, including a functional chimera 146LI, which was further optimized to generate 146LIS that can induce Lys48-specific polyubiquitination and reduce the protein level of HIV-1 NL4-3 integrase more effectively in cells. Lymphocyte cells with 146LIS knock-in generated by CRISPR/Cas-mediated homology-directed repair showed reduced integration of HIV-1 NL4-3 viral DNAs and viral replication without obvious cell cytotoxicity, providing a potential therapeutic strategy for inhibiting HIV infection.

VIROLOGICA SINICA (2021)

Review Virology

Budding of a Retrovirus: Some Assemblies Required

Kevin M. Rose et al.

VIRUSES-BASEL (2020)

Article Multidisciplinary Sciences

Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules

Yin-Wei Kuo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Physiology

Microtubules Stabilization by Mutant Spastin Affects ER Morphology and Ca2+ Handling

Nicola Vajente et al.

FRONTIERS IN PHYSIOLOGY (2019)

Review Biotechnology & Applied Microbiology

Novel host restriction factors implicated in HIV-1 replication

Dibya Ghimire et al.

JOURNAL OF GENERAL VIROLOGY (2018)

Article Virology

Nonenvelopment Role for the ESCRT-III Complex during Human Cytomegalovirus Infection

Nicholas T. Streck et al.

JOURNAL OF VIROLOGY (2018)

Article Biochemistry & Molecular Biology

A lanthipeptide library used to identify a protein-protein interaction inhibitor

Xiao Yang et al.

NATURE CHEMICAL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Inside job: how the ESCRTs release HIV-1 from infected cells

James H. Hurley et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2018)

Article Multidisciplinary Sciences

ALIX Is Recruited Temporarily into HIV-1 Budding Sites at the End of Gag Assembly

Pei-I Ku et al.

PLOS ONE (2014)

Article Cell Biology

An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome

Rachel Allison et al.

JOURNAL OF CELL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

The AAA ATPase spastin links microtubule severing to membrane modelling

Jennifer H. Lumb et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)

Article Medicine, Research & Experimental

HIV: Cell Binding and Entry

Craig B. Wilen et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Microbiology

ESCRT-III Protein Requirements for HIV-1 Budding

Eiji Morita et al.

CELL HOST & MICROBE (2011)

Article Endocrinology & Metabolism

A Novel Role for the AAA ATPase Spastin as a HOXA10 Transcriptional Corepressor in Ishikawa Endometrial Cells

Gaurang S. Daftary et al.

MOLECULAR ENDOCRINOLOGY (2011)

Article Cell Biology

Microtubule-dependent retrograde transport of bovine immunodeficiency virus

Yang Su et al.

CELLULAR MICROBIOLOGY (2010)

Article Biochemistry & Molecular Biology

Endosomal Trafficking of HIV-1 Gag and Genomic RNAs Regulates Viral Egress

Dorothee Molle et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Pleiotropic effects of spastin on neurite growth depending on expression levels

Elena Riano et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Article Cell Biology

Biochemical Analyses of Human IST1 and Its Function in Cytokinesis

Monika Bajorek et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Article Cell Biology

Essential Role of hIST1 in Cytokinesis

Monica Agromayor et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Article Multidisciplinary Sciences

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

Antonina Roll-Mecak et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B

Dong Yang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore

Nathalie J. Arhel et al.

EMBO JOURNAL (2007)

Article Cell Biology

Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane

AM Booth et al.

JOURNAL OF CELL BIOLOGY (2006)

Article Hematology

HIV interaction with endosornes in macrophages and dendritic cells

B Kramer et al.

BLOOD CELLS MOLECULES AND DISEASES (2005)

Article Clinical Neurology

The extent of axonal loss in the long tracts in hereditary spastic paraplegia

GC DeLuca et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2004)

Article Biochemistry & Molecular Biology

Evidence that HIV budding in primary macrophages occurs through the exosome release pathway

DG Nguyen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding

B Strack et al.

Article Biochemistry & Molecular Biology

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

JE Garrus et al.