Patients younger than 40 years with colorectal cancer have a similar prognosis to older patients

PurposeColorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. In recent years, the proportion of patients diagnosed with CRC at younger ages has increased. The clinicopathological features and oncological outcomes in younger patients with CRC remain controversial. We aimed to analyze the clinicopathological features and oncological outcomes in younger patients with CRC.MethodsWe examined 980 patients who underwent surgery for primary colorectal adenocarcinoma between 2006 and 2020. Patients were divided into two cohorts: younger (< 40 years old) and older (& GE; 40 years old).ResultsOf the 980 patients, 26 (2.7%) were under the age of 40 years. The younger group had more advanced disease (57.7% vs. 36.6%, p = 0.031) and more cases beyond the transverse colon (84.6% vs. 65.3%, p = 0.029) than the older group. Adjuvant chemotherapy was administered more frequently in the younger group (50% vs. 25.8%, p < 0.01). Relapse-free survival and overall survival were similar between the groups at all stages. Moreover, in stages II and III they were also comparable, regardless of the administration of adjuvant chemotherapy.ConclusionsYounger patients with CRC have a prognosis equivalent to that of older patients. Further studies are needed to establish the optimal treatment strategies for these patients.

Automated summary

The clinicopathological features and oncological outcomes in younger patients with CRC are controversial. This study aimed to analyze these features and outcomes. The results showed that younger patients had more advanced disease, more cases beyond the transverse colon, and received adjuvant chemotherapy more frequently. However, their relapse-free survival and overall survival were similar to older patients. Further studies are needed to establish optimal treatment strategies for younger patients.