Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine

Migraine is a pervasive neurologic disease closely related to neurogenic inflammation. The astrocytes and microglia in the central nervous system are vital in inducing neurogenic inflammation in migraine. Recently, it has been found that there may be a crosstalk phenomenon between microglia and astrocytes, which plays a crucial part in the pathology and treatment of Alzheimer's disease and other central nervous system diseases closely related to inflammation, thus becoming a novel hotspot in neuroimmune research. However, the role of the crosstalk between microglia and astrocytes in the pathogenesis and treatment of migraine is yet to be discussed. Based on the preliminary literature reports, we have reviewed relevant evidence of the crosstalk between microglia and astrocytes in the pathogenesis of migraine and summarized the crosstalk pathways, thereby hoping to provide novel ideas for future research and treatment.

Automated summary

Migraine, a prevalent neurological disease, is closely associated with neurogenic inflammation. The interaction between microglia and astrocytes, crucial in the pathology of Alzheimer's disease and other inflammation-related central nervous system diseases, has recently emerged as a novel focus in neuroimmune research. However, the role of this interaction in the pathogenesis and treatment of migraine remains to be explored. By reviewing relevant evidence, we aim to provide new insights for future research and treatment.