Advances in cell membrane-coated nanoparticles and their applications for bone therapy

Due to the specific structure of natural bone, most of the therapeutics are incapable to be delivered into the targeted site with effective concentrations. Nanotechnology has provided a good way to improve this issue, cell membrane mimetic nanoparticles (NPs) have been emerging as an ideal nanomaterial which integrates the advantages of natural cell membranes with synthetic NPs to significantly improve the biocompatibility as well as achieving long-lasting circulation and targeted delivery. In addition, functionalized modifications of the cell membrane facilitate more precise targeting and therapy. Here, an overview of the preparation of cell membranecoated NPs and the properties of cell membranes from different cell sources has been given to expatiate their function and potential applications. Strategies for functionalized modification of cell membranes are also briefly described. The application of cell membrane-coated NPs for bone therapy is then presented according to the function of cell membranes. Moreover, the prospects and challenges of cell membrane-coated NPs for translational medicine have also been discussed.

Automated summary

Due to the specific structure of natural bone, most therapeutics are unable to effectively reach the targeted site. Nanotechnology provides a solution by using cell membrane mimetic nanoparticles, which combine the advantages of natural cell membranes with synthetic nanoparticles to improve biocompatibility, circulation, and targeted delivery. This article provides an overview of the preparation and properties of cell membrane-coated nanoparticles, as well as their potential applications in bone therapy. The functionalized modification of cell membranes and the prospects and challenges of using cell membrane-coated nanoparticles in translational medicine are also discussed.