3.8 Review

Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications

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An overview of microneedle applications, materials, and fabrication methods

Zahra Faraji Rad et al.

Summary: Microneedle-based microdevices offer a new way to deliver vaccines and therapeutic agents through the skin and extract biofluids for point-of-care diagnostics. They provide advantages over hypodermic needles with the benefits of unskilled and painless applications for blood collection or drug delivery. Development of microneedle fabrication processes has the potential to revolutionize health care delivery by changing the landscape of fluid sampling and subcutaneous drug delivery.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2021)

Review Polymer Science

3D/4D Printing of Polymers: Fused Deposition Modelling (FDM), Selective Laser Sintering (SLS), and Stereolithography (SLA)

Abishek Kafle et al.

Summary: This article discusses three widely used polymer-based 3D printing processes - FDM, SLS, and SLA, providing a comparative overview of material-process-properties and advanced requirements for 4D printing. It also serves as a guide for selecting suitable print materials and techniques for polymer-based applications, as well as discussing implementation practices towards 4D printing of polymer-based systems.

POLYMERS (2021)

Review Polymer Science

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

Faisal Khaled Aldawood et al.

Summary: Drug delivery through the skin offers advantages such as avoiding hepatic metabolism and maintaining steady plasma concentration, but only a limited number of drugs with ideal properties can achieve therapeutic concentrations. Microneedles are a promising physical enhancement method to expand the spectrum of drugs for transdermal delivery. Different materials used for microneedles have implications for transdermal drug delivery, but challenges in sustained delivery, efficacy, cost-effective fabrication, and large-scale manufacturing remain. Microneedles have potential impact on drug delivery, vaccine delivery, disease diagnostics, and cosmetics applications.

POLYMERS (2021)

Article Nanoscience & Nanotechnology

Optimization of the fused deposition modeling-based fabrication process for polylactic acid microneedles

Libo Wu et al.

Summary: Micro needle arrays are novel biomedical devices used in medical applications to penetrate the skin layers, with their structure significantly impacting mechanical properties. Fused deposition modeling is a promising 3D printing method for manufacturing micron-scale micro needles.

MICROSYSTEMS & NANOENGINEERING (2021)

Review Nanoscience & Nanotechnology

High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays

Zahra Faraji Rad et al.

Summary: Microneedle patches have gained popularity for drug/vaccine delivery and fluid sampling systems. Additive manufacturing techniques, like 2PP, allow for precise fabrication of microstructures such as microneedle arrays, overcoming limitations of traditional manufacturing methods.

MICROSYSTEMS & NANOENGINEERING (2021)

Article Pharmacology & Pharmacy

Improved Therapeutic Efficiency against Obesity through Transdermal Drug Delivery Using Microneedle Arrays

Yixuan Xie et al.

Summary: The study demonstrated that transdermal delivery of anti-obesity drugs through microneedle arrays resulted in weight loss and increased expression of UCP1 protein in brown adipose tissue, indicating a more effective treatment for obesity.

PHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Prateek Ranjan Yadav et al.

Summary: This review paper discusses the key points for the translation of microneedles from laboratory to clinical practice, focusing on the choice of polymeric microneedles, fabrication methods, materials choice, and the future of microneedles in public healthcare services.

PHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

Emerging era of microneedle array for pharmaceutical and biomedical applications: recent advances and toxicological perspectives

Shailesh Dugam et al.

Summary: This review article delves into the current applications of microneedles in drug delivery, discussing fabrication materials, advantages, pharmacokinetics, toxicity, biosafety, and clinical trials. It highlights the potential of microneedles in pharmaceutical and biomedical fields, paving the way for future advancements.

FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Article Engineering, Manufacturing

Precision micro-milling process: state of the art

Lorcan O'Toole et al.

Summary: Micro-milling is a precision manufacturing process that finds applications in various industries for its versatility and efficiency. Despite challenges posed by physical phenomena during micro-milling, through in-depth research and discussions, improvements can be made to enhance the overall process. Additionally, the combination of conventional micro-milling with other technologies shows promising potential in addressing issues related to physical process phenomena.

ADVANCES IN MANUFACTURING (2021)

Article Pharmacology & Pharmacy

Engineering and characterisation of BCG-loaded polymeric microneedles

Muhammad Sohail Arshad et al.

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Article Nanoscience & Nanotechnology

Multifunctional Graphene-Oxide-Reinforced Dissolvable Polymeric Microneedles for Transdermal Drug Delivery

Yongli Chen et al.

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4D Printing of a Bioinspired Microneedle Array with Backward-Facing Barbs for Enhanced Tissue Adhesion

Daehoon Han et al.

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Microneedles for transdermal diagnostics: Recent advances and new horizons

Gui-Shi Liu et al.

BIOMATERIALS (2020)

Article Biochemistry & Molecular Biology

Pullulan-based dissolving microneedle arrays for enhanced transdermal delivery of small and large biomolecules

Lalitkumar K. Vora et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Pharmacology & Pharmacy

Poly (vinyl alcohol)/chitosan layer-by-layer microneedles for cancer chemo-photothermal therapy

Andre F. Moreira et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Article Engineering, Biomedical

Biodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug

Xingwu Zhou et al.

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Hyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini Review

Kang Nien How et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

Belen Begines et al.

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Direct Ink Writing Based 4D Printing of Materials and Their Applications

Xue Wan et al.

ADVANCED SCIENCE (2020)

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Microneedle-Based Delivery: An Overview of Current Applications and Trends

Antonio Jose Guillot et al.

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Hydrogel-forming microneedle arrays as a therapeutic option for transdermal esketamine delivery

Aaron J. Courtenay et al.

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Article Chemistry, Multidisciplinary

Construction of microneedle-assisted co-delivery platform and its combining photodynamic/immunotherapy

Shi-Xiong Chen et al.

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Article Engineering, Biomedical

Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing

Junjie Chi et al.

BIOACTIVE MATERIALS (2020)

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Current trends in polymer microneedle for transdermal drug delivery

Khater Ahmed Saeed AL-Japairai et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Pharmacology & Pharmacy

A review of recent advances in microneedle technology for transdermal drug delivery

Rigved Nagarkar et al.

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Study on the fabrication and characterization of tip-loaded dissolving microneedles for transdermal drug delivery

Jian Zhuang et al.

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Review Pharmacology & Pharmacy

Microneedles Drug Delivery Systems for Treatment of Cancer: A Recent Update

Aravindram Attiguppe Seetharam et al.

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Fabrication of aminated poly(glycidyl methacrylate)-based polymers for co-delivery of anticancer drugs and the p53 gene

Lei Li et al.

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Engineering materials with light: recent progress in digital light processing based 3D printing

Zhi Zhao et al.

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Electrospinning/electrospraying coatings for metal microneedles: A design of experiments (DOE) and quality by design (QbD) approach

Radeyah Ali et al.

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Article Pharmacology & Pharmacy

Dissolvable microneedle patch containing doxorubicin and docetaxel is effective in 4T1 xenografted breast cancer mouse model

Shubhmita Bhatnagar et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Review Engineering, Chemical

A review on microfabrication of thermoplastic polymer-based microneedle arrays

Herwig Juster et al.

POLYMER ENGINEERING AND SCIENCE (2019)

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Design of composite microneedle sensor systems for the measurement of transdermal pH

Catherine Hegarty et al.

MATERIALS CHEMISTRY AND PHYSICS (2019)

Review Medicine, Research & Experimental

Microneedles: A smart approach and increasing potential for transdermal drug delivery system

Tejashree Waghule et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Materials Science, Multidisciplinary

Functionalization of Carbon Nanomaterials for Biomedical Applications

Wei Liu et al.

C-JOURNAL OF CARBON RESEARCH (2019)

Review Engineering, Biomedical

Stimuli-Responsive Drug Release from Smart Polymers

Carlos M. Wells et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2019)

Review Instruments & Instrumentation

An update on coating/manufacturing techniques of microneedles

Tamara N. Tarbox et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2018)

Review Pharmacology & Pharmacy

Polymeric microneedles for transdermal protein delivery

Yanqi Ye et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Article Pharmacology & Pharmacy

Dissolving polymeric microneedle arrays for enhanced site-specific acyclovir delivery

Boonnada Pamornpathomkul et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Article Pharmacology & Pharmacy

Poly (vinyl alcohol) microneedles: Fabrication, characterization, and application for transdermal drug delivery of doxorubicin

Hiep X. Nguyen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

Review Chemistry, Multidisciplinary

Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

Alexey S. Rzhevskiy et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Review Pharmacology & Pharmacy

Ceramic microneedles and hollow microneedles for transdermal drug delivery: Two decades of research

Kevin Ita

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2018)

Article Pharmacology & Pharmacy

In vitro and in vivo assessment of polymer microneedles for controlled transdermal drug delivery

Bo Zhi Chen et al.

JOURNAL OF DRUG TARGETING (2018)

Article Materials Science, Biomaterials

Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats

Yang Zhang et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

Article Pharmacology & Pharmacy

Dissolving microneedles for enhanced local delivery of capsaicin to rat skin tissue

Yukako Ito et al.

JOURNAL OF DRUG TARGETING (2017)

Article Chemistry, Multidisciplinary

A self-adherent, bullet-shaped microneedle patch for controlled transdermal delivery of insulin

Keum-Yong Seong et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Article Chemistry, Multidisciplinary

Anti-obesity effect of a novel caffeine-loaded dissolving microneedle patch in high-fat diet-induced obese C57BL/6J mice

Manita Dangol et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Review Chemistry, Multidisciplinary

Microneedle, bio-microneedle and bio-inspired microneedle: A review

Guojun Ma et al.

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Article Chemistry, Multidisciplinary

Biocompatible polymer microneedle for topical/dermal delivery of tranexamic acid

S. A. Machekposhti et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Article Engineering, Chemical

Spin coating of polymer solution on polydimethylsiloxane mold for fabrication of microneedle patch

Ming-Ta Lee et al.

JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS (2017)

Article Materials Science, Biomaterials

Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin

Weijiang Yu et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

Article Nanoscience & Nanotechnology

DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles

Ahlam A. Ali et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

Review Dermatology

Melasma: an Up-to-Date Comprehensive Review

Oluwatobi A. Ogbechie-Godec et al.

DERMATOLOGY AND THERAPY (2017)

Article Medicine, Research & Experimental

Dissolving microneedles for transdermal drug delivery: Advances and challenges

Kevin Ita

BIOMEDICINE & PHARMACOTHERAPY (2017)

Review Nanoscience & Nanotechnology

Lithography-based methods to manufacture biomaterials at small scales

Khanh T. M. Tran et al.

JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES (2017)

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Dextran-based Nanocarriers for Delivery of Bioactives

Rania A. H. Ishak et al.

CURRENT PHARMACEUTICAL DESIGN (2016)

Article Chemistry, Multidisciplinary

Innovative polymeric system (IPS) for solvent-free lipophilic drug transdermal delivery via dissolving microneedles

Manita Dangol et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Article Chemistry, Analytical

Polymeric microneedles based enzymatic electrodes for electrochemical biosensing of glucose and lactic acid

A. Calio et al.

SENSORS AND ACTUATORS B-CHEMICAL (2016)

Article Instruments & Instrumentation

Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery

Raghu Raj Singh Thakur et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2016)

Article Computer Science, Information Systems

Digital Transformation Strategies

Christian Matt et al.

BUSINESS & INFORMATION SYSTEMS ENGINEERING (2015)

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Hollow polymer microneedles array resistance and insertion tests

Marion Sausse Lhernould et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

Article Materials Science, Multidisciplinary

Development of Low Cost Rapid Fabrication of Sharp Polymer Microneedles for In Vivo Glucose Biosensing Applications

Colm Barrett et al.

ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY (2015)

Review Engineering, Manufacturing

4D Printing Technology: A Review

Jin Choi et al.

3D PRINTING AND ADDITIVE MANUFACTURING (2015)

Review Pharmacology & Pharmacy

Microneedle Coating Techniques for Transdermal Drug Delivery

Rita Haj-Ahmad et al.

PHARMACEUTICS (2015)

Article Engineering, Biomedical

Cell surface engineering to enhance mesenchymal stem cell migration toward an SDF-1 gradient

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BIOMATERIALS (2014)

Article Pharmacology & Pharmacy

Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration

Marie G. McGrath et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)

Article Chemistry, Multidisciplinary

Investigation of electron transfer from isolated spinach thylakoids to indium tin oxide

Herlina Arianita Dewi et al.

RSC ADVANCES (2014)

Article Engineering, Biomedical

Chitin Microneedles for an Easy-to-Use Tuberculosis Skin Test

Jungho Jin et al.

ADVANCED HEALTHCARE MATERIALS (2014)

Article Biochemistry & Molecular Biology

Chitosan Microneedle Patches for Sustained Transdermal Delivery of Macromolecules

Mei-Chin Chen et al.

BIOMACROMOLECULES (2012)

Article Chemistry, Multidisciplinary

Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery

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JOURNAL OF CONTROLLED RELEASE (2012)

Review Pharmacology & Pharmacy

Microneedles: A Valuable Physical Enhancer to Increase Transdermal Drug Delivery

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JOURNAL OF CLINICAL PHARMACOLOGY (2011)

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Nanofibre fabrication in a temperature and humidity controlled environment for improved fibre consistency

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JOURNAL OF MATERIALS SCIENCE (2011)

Review Pharmacology & Pharmacy

Two-photon polymerization of microneedles for transdermal drug delivery

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EXPERT OPINION ON DRUG DELIVERY (2010)

Article Biochemistry & Molecular Biology

Dissolving polymer microneedle patches for influenza vaccination

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A novel fabrication process for out-of-plane microneedle sheets of biocompatible polymer

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