Journal
TALANTA
Volume 265, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2023.124805
Keywords
Theranostics; Photosensitive metal-organic framework; DNA logic Circuits; MicroRNA; Photodynamic therapy
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A versatile MOF-derived theranostic system (DAPM) was developed for precise detection and monitoring of miRNAs in living tumor cells. The DAPM probe showed sensitive detection of miR-21 and miR-155, providing a low limit of detection. Furthermore, the DAPM system exhibited enhanced tumor cell recognition and efficient ROS generation, enabling effective photodynamic therapy for anti-tumors.
Precise detection and monitoring of microRNAs (miRNAs) in living tumor cells is significant for the prompt diagnosis of cancer and provides important information for treatment of cancer. A significant challenge is developing methods for imaging different miRNAs simultaneously to further enhance diagnostic and treatment accuracy. In this work, a versatile MOF-derived theranostic system (DAPM) was constructed using photosensitive metal-organic frameworks (PMOF, PM) and a DNA AND logic gate (DA). The DAPM exhibited excellent bio-stability and enabled sensitive detection of miR-21 and miR-155, achieving a low limit of detection (LOD) for miR-21 (89.10 pM) and miR-155 (54.02 pM). The DAPM probe generated a fluorescence signal in tumor cells where miR-21 and miR-155 co-existed, demonstrating the enhanced ability of tumor cell recognition. Addi-tionally, the DAPM achieved efficient ROS generation and concentration-dependent cytotoxicity under light irradiation, providing effective photodynamic therapy for anti-tumors. The proposed DAPM theranostic system enables accurate cancer diagnosis, and provides spatial and temporal information for PDT.
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