Journal
DALTON TRANSACTIONS
Volume 52, Issue 30, Pages 10286-10293Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3dt01798b
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Human acute monocytic leukaemia cells were more sensitive to a Ru(ii) carbonyl complex (IC50 = 7.13 ± 0.8 μM) with a diphenyl pyridyl phosphine coligand under dark conditions compared to a Mn(i) analogue (IC50 = 54.58 ± 4.1 μM). Both complexes showed no toxicity to healthy mouse bone marrow cells.
Human acute monocytic leukaemia cells were tested under both dark and light conditions for their susceptibility to Mn(i) and Ru(ii) carbonyl complexes with a diphenyl pyridyl phosphine coligand. The Ru(ii) complex (IC50 = 7.13 & PLUSMN; 0.8 & mu;M) displayed higher outstanding potency against leukaemia than the Mn(i) analogue (54.58 & PLUSMN; 4.1 & mu;M) in the dark and both complexes were completely harmless to healthy mouse bone marrow cells.
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