In vitro cytotoxicity of Mn(i) and Ru(ii) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia

Human acute monocytic leukaemia cells were tested under both dark and light conditions for their susceptibility to Mn(i) and Ru(ii) carbonyl complexes with a diphenyl pyridyl phosphine coligand. The Ru(ii) complex (IC50 = 7.13 & PLUSMN; 0.8 & mu;M) displayed higher outstanding potency against leukaemia than the Mn(i) analogue (54.58 & PLUSMN; 4.1 & mu;M) in the dark and both complexes were completely harmless to healthy mouse bone marrow cells.

Automated summary

Human acute monocytic leukaemia cells were more sensitive to a Ru(ii) carbonyl complex (IC50 = 7.13 ± 0.8 μM) with a diphenyl pyridyl phosphine coligand under dark conditions compared to a Mn(i) analogue (IC50 = 54.58 ± 4.1 μM). Both complexes showed no toxicity to healthy mouse bone marrow cells.