Journal
ADVANCED HEALTHCARE MATERIALS
Volume 5, Issue 10, Pages 1169-1176Publisher
WILEY
DOI: 10.1002/adhm.201501013
Keywords
cancer immunoadjuvant; immune memory; mechanism; mesoporous silica nanoparticle; Th1 immunity
Funding
- KAKENHI [26750162, 23700567]
- Grants-in-Aid for Scientific Research [23700567, 26750162] Funding Source: KAKEN
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A plain mesoporous silica nanoparticle without any immunomodulatory molecules significantly enhances anticancer immunity in vivo. Comprehensive mechanism of mesoporous-silica-nanoparticle-induced cancer immunotherapy is analyzed in this paper. The mesoporous silica nanoparticle promotes both Th1 and Th2 immune responses, as it accelerates lymphocytes proliferation, stimulates IFN-, IL-2, IL-4, and IL-10 cytokine secretion by lymphocytes ex vivo, and increases IgG, IgG1, IgG2a, IgM, and IgA antibody titers in mice serum compared with those of alum and adjuvant-free groups. Moreover, the mesoporous silica nanoparticle enhances effector memory CD4(+) and CD8(+) T cell populations in three most important immune organs (bone marrow, lymph node, and spleen) of mice compared with those of alum and adjuvant-free groups three months after adjuvant injection. The present study paves the way for the application of mesoporous silica nanoparticle as immunoadjuvant for cancer immunotherapy.
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