Journal
ADVANCED HEALTHCARE MATERIALS
Volume 5, Issue 19, Pages 2528-2535Publisher
WILEY
DOI: 10.1002/adhm.201600312
Keywords
-
Funding
- Agency for Science, Technology and Research (A*STAR), Singapore [1431AFG127, IMRE/14-1C0420]
Ask authors/readers for more resources
This paper reports a novel synthesis approach of bovine serum albumin (BSA) protein-templated ultrasmall (<2 nm) Ag nanocluster (NC) with strong singlet oxygen generation capacity for photodynamic therapy (PDT). An ;atomically precise BSA-Ag-13 NC (i.e., 13 Ag atoms per cluster) is successfully synthesized for the first time by using NaOH-dissolved NaBH 4 solution as the controlling reducing agent. The ubiquitous size of BSA-Ag-13 NC results in unique behaviors of its photoexcited states as characterized by the ultrafast laser spectroscopy using time-correlated single photon counting and transient absorption techniques. In particular, triply excited states can be largely present in the excited BSA-Ag-13 NC and readily sensitized molecular oxygen to produce singlet oxygen (O-1(2)) with a high quantum efficiency (approximate to 1.26 using Rose Bengal as a standard). This value is much higher than its Au analogue (i.e., approximate to 0.07 for BSA-Au-25 NC) and the commonly available photosensitizers. Due to the good cellular uptake and inherent biocompatibility imparted by the surface protein, BSA-Ag-13 NC can be applied as an effective PDT agent in generating O-1(2) to kill cancer cell as demonstrated in this study.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available