Journal
ADVANCED HEALTHCARE MATERIALS
Volume 6, Issue 4, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201601195
Keywords
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Funding
- Spanish Ministerio de Educacion y Ciencia [MAT2016-75362-C3-1-R, MAT2013-47395-C4-1-R, MAT2010-16161, MAT2010-21270-C04-01]
- EU Framework Programme [COST-CM1403]
- FINEP (Financiadora de Estudos e Projetos) [INFRAPESQ-11, INFRAPESQ-12]
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [INCT NANO(BIO)SIMES, 483238/2013-9]
- CAPES (Coordenadoria de Aperfeicoamento de Pessoal de Ensino Superior) [A077/2013]
- CNPq
- PVE [A077/2013]
- PVE (Pesquisador Visitante Especial) [A077/2013]
- Post Doctoral Fellowship grant PDE/CAPES at the Universidad Autonoma de Madrid-Spain [2108-14-3]
- Universidad Autonoma de Madrid through an FPI grant
- Merit Scholarship Program for Foreign Students from the Ministere de L'Education, du Loisir et du Sport du Quebec (MELS)
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Fonds de recherche du Quebec-Nature et technologies (FRQNT)
- Canada Foundation for Innovation (CFI)
- NSERC
- FRQNT
- CFI
- Centre Quebecois sur les Materiaux Fonctionnels (CQMF), Canada
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There is an urgent need to develop new diagnosis tools for real in vivo detection of first stages of ischemia for the early treatment of cardiovascular diseases and accidents. However, traditional approaches show low sensitivity and a limited penetration into tissues, so they are only applicable for the detection of surface lesions. Here, it is shown how the superior thermal sensing capabilities of near infrared-emitting quantum dots (NIR-QDs) can be efficiently used for in vivo detection of subcutaneous ischemic tissues. In particular, NIR-QDs make possible ischemia detection by high penetration transient thermometry studies in a murine ischemic hindlimb model. NIR-QDs nanothermometers are able to identify ischemic tissues by means of their faster thermal dynamics. In addition, they have shown to be capable of monitoring both the revascularization and damage recovery processes of ischemic tissues. This work demonstrates the applicability of fluorescence nanothermometry for ischemia detection and treatment, as well as a tool for early diagnosis of cardiovascular disease.
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