4.7 Article

Using a Redox Modality to Connect Synthetic Biology to Electronics: Hydrogel-Based Chemo-Electro Signal Transduction for Molecular Communication

Journal

ADVANCED HEALTHCARE MATERIALS
Volume 6, Issue 1, Pages -

Publisher

WILEY
DOI: 10.1002/adhm.201600908

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Funding

  1. National Science Foundation [CBET-1435957]
  2. Department of Defense (Defense Threat Reduction Agency) [HDTRA1-13-1-0037]
  3. USDA-National Institute of Food and Agriculture [20146702121585]
  4. Directorate For Engineering
  5. Div Of Chem, Bioeng, Env, & Transp Sys [1435957] Funding Source: National Science Foundation

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A hydrogel-based dual film coating is electrofabricated for transducing bio-relevant chemical information into electronical output. The outer film has a synthetic biology construct that recognizes an external molecular signal and transduces this input into the expression of an enzyme that converts redox-inactive substrate into a redox-active intermediate, which is detected through an amplification mechanism of the inner redox-capacitor film.

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