Journal
ADVANCED HEALTHCARE MATERIALS
Volume 5, Issue 8, Pages 907-918Publisher
WILEY
DOI: 10.1002/adhm.201501018
Keywords
angiogenesis; diabetic wounds; drug release; hydrogel nanofibers; vessel regeneration
Funding
- Natural Science Foundation of China [81371958, 81061160510, 51373112]
- Basic Key Project of Science and Technology Commission of Shanghai Municipality [12JC1408200]
- Scientific and Technological Support Program in Biological Medicine of Science and Technology Commission of Shanghai Municipality [13431900702]
- Jane and Aatos Erkko Foundation [4704010]
- Academy of Finland [252215, 281300]
- University of Helsinki, Biocentrum Helsinki
- European Research Council under the European Union [310892]
Ask authors/readers for more resources
Nonhealing chronic wounds on foot are one of the most dreaded complications of diabetes, and biomedical scaffolds remain an attractive option for repairing or regenerating tissues. Accelerating angiogenesis in the early stage after injury is critical to wound healing process; however, the scaffolds accelerate the angiogenesis in the beginning but with the acceleration of vessel network formation the scaffold network hinders the process. In this study, the water soluble drugs-loaded hydrogel nanofibrous scaffolds are designed for rapidly recruiting angiogenesis relative cells and promoting wound healing. The sustained release profile of desferrioxamine (DFO), which continues for about 72 h, leads to significantly increase of neovascularization. The majority of the scaffold is degraded in 14 d, leaving enough space for cell proliferation and vessel formation. The in vitro results show that the scaffolds upregulate the expression of Hif-1 and vascular endothelial growth factor, and enhance the interaction between fibroblasts and endothelial cells. The in vivo studies show a higher expression of angiogenesis related cytokines. This study demonstrates that the DFO released from hydrogel nanofibrous scaffolds of quick degradation can interfere with the required prolyl-hydroxylases cofactors by acting as Fe2+ chelator and upregulate the expression of Hif-1, leading to a significant increase of the neovascularization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available