Journal
ADVANCED HEALTHCARE MATERIALS
Volume 5, Issue 5, Pages 541-547Publisher
WILEY
DOI: 10.1002/adhm.201500757
Keywords
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Funding
- NIH [R01 DE013349, R01 EB015498]
- ARO [63846LS]
- HHMI ISRF
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Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for high viability of encapsulated cells, establishment of 3D elongated cell morphologies, and biodegradation when injected in vivo.
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