Journal
ADVANCED HEALTHCARE MATERIALS
Volume 6, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201600919
Keywords
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Funding
- National Basic Research Program of China (973 Program) [2012CB933600]
- National Natural Science Foundation of China [51373138, 21574105]
- Sichuan Province Youth Science and Technology Innovation Team [2016TD0026]
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The development of a nanocarrier with a capacity of releasing therapeutic agent on demand is of great importance for enhancing drug efficacy and reducing its side effect. Here, a multifunctional mesoporous silica nanoparticle is presented for cancer therapy. This nanoparticle can not only successively target tumor tissue and tumor cells but also has a function of controllably switching the drug release. Low molecular weight poly(ethyleneimine) segments, which are decorated on the surface of magnetic mesoporous silica nanoparticle with disulfide bonds, are chemically cross-linked, leading to the mesopores being closed in blood circulation but being open via taking off the coating in cytoplasm. As a result, the encapsulated drug can be kept in nanoparticles in the normal conditions, while be rapidly released in a reduction condition. In vivo antitumor activity demonstrates that this nanoparticle has the highest safety to body and the best therapeutic efficacy against tumors. Therefore, this work presents a good example of rational design of nanocarriers for highly effective cancer therapy.
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